Early life stress induces irritable bowel syndrome from childhood to adulthood in mice

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Окт. 2, 2023

Background Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorder. Traditionally, early life stress (ELS) predisposed to IBS in adult. However, whether ELS induces remains unclear. Methods Separated cohort studies were conducted neonatal male pups C57BL/6 mice by maternal separation (MS) model. MS and non-separation scheduled be evaluated for prime IBS-phenotypes, including visceral hypersensitivity, intestinal motility, permeability, anxiety-like behavior. Ileal contents fecal samples collected analyzed 16S rRNA gene sequencing bacterial community analyses. Subcellular structures epithelial, such as epithelial tight junctions mitochondria, observed under transmission electron microscopy. Results induced hypersensitivity decreased total transit time from childhood adulthood. In addition, hyperpermeability behavior adolescence Besides, affected microbial composition Moreover, disrupted mitochondrial structure Conclusion The study showed first that adulthood mice. significant dysbiosis microbiota may contribute initiation progress

Язык: Английский

---

Addressing the biological embedding of early life adversities (ELA) among adults through mindfulness: Proposed mechanisms and review of converging evidence

Neuroscience & Biobehavioral Reviews, Год журнала: 2022, Номер 134, С. 104526 - 104526

Опубликована: Янв. 5, 2022

Язык: Английский

---

Double perinatal stress reduces the sexual response of adult female Wistar rats

The Journal of Sexual Medicine, Год журнала: 2023, Номер 20(6), С. 742 - 748

Опубликована: Апрель 10, 2023

Язык: Английский

---

Effects of natural products on skin inflammation caused by abnormal hormones secreted by the adrenal gland

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Май 3, 2023

The cortex of adrenal gland produces glucocorticoid, mineralocorticoid, and androgen. medulla secrets catecholamines. These hormones play an important role in regulating blood pressure, metabolism, homeostasis glucose or electrolytes. Hypersecretion hyposecretion by the will cause a complex cascade hormone effects lead to diseases, including Addison’s disease, Cushing’s syndrome, congenital cortical hyperplasia. Skin is largest organ body. It provides protection acts as barrier against external damage factors like infectious organisms, chemicals, allergens. Endocrinologic disorders often induce cutaneous abnormalities. According previous evidences, natural products have potential properties for attenuating skin improving dermatologic symptoms inhibiting inflammation through MAPK PI3K/AKT-dependent NF-κB pathways. may also promote wound healing production matrix metalloproteinase-9. We systematically searched relevant articles from databases, PubMed, Embase, Cochrane library review on disorders. This article summarized caused abnormal secreted gland. And published papers indicated that might be source treating diseases.

Язык: Английский

---

The effects of childhood maltreatment on social support, inflammation, and depressive symptoms in adulthood

Social Science & Medicine, Год журнала: 2023, Номер 340, С. 116481 - 116481

Опубликована: Дек. 3, 2023

Язык: Английский

---