Pathology - Research and Practice, Год журнала: 2024, Номер 254, С. 155156 - 155156
Опубликована: Янв. 26, 2024
Язык: Английский
Chemico-Biological Interactions, Год журнала: 2023, Номер 378, С. 110482 - 110482
Опубликована: Апрель 10, 2023
Язык: Английский
Процитировано
87
Pathology - Research and Practice, Год журнала: 2024, Номер 255, С. 155157 - 155157
Опубликована: Янв. 26, 2024
Язык: Английский
Процитировано
49
Biogerontology, Год журнала: 2025, Номер 26(2)
Опубликована: Фев. 26, 2025
Abstract Cellular senescence and hypoxia-inducible factor (HIF) signaling are crucial in pulmonary aging age-related lung diseases such as chronic obstructive disease idiopathic fibrosis cancer. HIF plays a pivotal role cellular adaptation to hypoxia, regulating processes like angiogenesis, metabolism, inflammation. Meanwhile, leads irreversible cell cycle arrest, triggering the senescence-associated secretory phenotype which contributes inflammation, tissue remodeling, fibrosis. Dysregulation of these pathways accelerates progression by promoting oxidative stress, mitochondrial dysfunction, epigenetic alterations. Recent studies indicate that interact at multiple levels, where can both induce suppress senescence, depending on conditions. While transient activation supports repair stress resistance, dysregulation exacerbates pathologies. Furthermore, emerging evidence suggests targeting could offer new therapeutic strategies mitigate diseases. This review explores intricate crosstalk between mechanisms, shedding light how their interplay influences progression. Additionally, we discuss potential interventions, including senolytic therapies modulators, enhance health longevity.
Язык: Английский
Процитировано
3
ACS Nano, Год журнала: 2023, Номер 17(24), С. 24988 - 25004
Опубликована: Дек. 12, 2023
Nanoplastics are a common type of contaminant in the air. However, no investigations have focused on toxic mechanism lung injury induced by nanoplastic exposure. In present study, polystyrene nanoplastics (PS-NPs) caused ferroptosis epithelial cells, which could be alleviated ferrostatin-1, deferoxamine, and N-acetylcysteine. Further investigation found that PS-NPs disturbed mitochondrial structure function triggered autophagy. Mechanistically, oxidative stress-derived damage contributed to ferroptosis, autophagy-dependent ferritinophagy was pivotal intermediate link, resulting ferritin degradation iron ion release. Furthermore, inhibition using ferrostatin-1 pulmonary systemic toxicity reverse mouse inhalation. Most importantly, lung-on-a-chip further used clarify role PS-NPs-induced visualizing stress, alveolar-capillary barrier dysfunction at organ level. summary, our study indicated an important for nanoplastics-induced through different inhalation models, three-dimensional-based lung-on-a-chip, providing insightful reference assessment nanoplastics.
Язык: Английский
Процитировано
44
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2023, Номер 397(5), С. 2793 - 2833
Опубликована: Ноя. 22, 2023
Язык: Английский
Процитировано
33
Pathology - Research and Practice, Год журнала: 2024, Номер 256, С. 155259 - 155259
Опубликована: Март 11, 2024
Язык: Английский
Процитировано
12
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(14), С. 11538 - 11538
Опубликована: Июль 16, 2023
Ageing constitutes the biggest risk factor for poor health and adversely affects integrity function of all cells, tissues, organs in human body. Vascular ageing, characterised by vascular stiffness, endothelial dysfunction, increased oxidative stress, chronic low-grade inflammation, early-stage atherosclerosis, may trigger or exacerbate development age-related diseases, which each year contribute to more than 3.8 million deaths Europe alone necessitate a better understanding mechanisms involved. To this end, large number recent preclinical clinical studies have focused on exponential accumulation senescent cells system paid particular attention specific roles senescence-associated secretory phenotype, proteostasis age-mediated modulation certain microRNA (miRNAs), contribution other major factors, notably diabetes, hypertension, smoking, ageing elderly. The data generated paved way various senotherapeutic interventions, ranging from application synthetic natural senolytics senomorphics attempt modify lifestyle, control diet, restrict calorie intake. However, guidelines, considering severity characteristics need be established before widespread use these agents. This review briefly discusses molecular cellular summarises efficacy widely studied senotherapeutics context ageing.
Язык: Английский
Процитировано
22
Biomedicines, Год журнала: 2024, Номер 12(4), С. 814 - 814
Опубликована: Апрель 7, 2024
Chronic obstructive pulmonary disease (COPD) is a prevalent and debilitating respiratory disorder characterized by persistent airflow limitation chronic inflammation. In recent years, the role of mitochondrial dysfunction in COPD pathogenesis has emerged as focal point investigation. This review endeavors to unravel molecular nexus between COPD, delving into intricate interplay oxidative stress, bioenergetic impairment, genetics, downstream cellular consequences. Oxidative consequence dysfunction, explored driving force behind inflammation, exacerbating cascade events leading progression. Bioenergetic impairment sheds light on systemic consequences impacting functions contributing overall energy imbalance observed patients. navigates through genetic landscape, elucidating DNA mutations, variations, haplogroups susceptibility severity. Cellular consequences, including apoptosis, autophagy, senescence, are examined, providing insights mechanisms which influences pathology. Therapeutic implications, spanning antioxidant strategies, mitochondria-targeted compounds, lifestyle modifications, discussed context translational research. Important future directions include identifying novel biomarkers, advancing therapies, embracing patient-centric approaches redefine management. abstract provides comprehensive overview our review, offering roadmap for understanding addressing with potential implications precision medicine improved patient outcomes.
Язык: Английский
Процитировано
8
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Авг. 20, 2024
Mitochondria play a significant and varied role in inflammatory lung disorders. Mitochondria, known as the powerhouse of cell because their producing energy, are now recognized crucial regulators inflammation immunological responses. Asthma, chronic obstructive pulmonary disease, acute respiratory distress syndrome characterized by complex interactions between immune cells, substances, tissue damage. Dysfunctional mitochondria can increase generation reactive oxygen species (ROS), triggering pathways. Moreover, mitochondrial failure impacts cellular signaling, which turn affects expression molecules that promote inflammation. In addition, have controlling behavior such activation differentiation, is essential development diseases. Their dynamic behavior, encompassing fusion, fission, mitophagy, also responses to oxidative stress. Gaining comprehensive understanding intricate correlation order develop accurate treatment strategies. Targeting ROS generation, dynamics, function may offer novel approaches treating diseases while minimizing Additional investigation into precise contributions will provide knowledge regarding disease mechanisms potential therapeutic approaches. This review focus on how regulate these processes involvement
Язык: Английский
Процитировано
7
Inflammation Research, Год журнала: 2025, Номер 74(1)
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
1