Bioelectric Membrane Potential and Breast Cancer: Advances in Neuroreceptor Pharmacology for Targeted Therapeutic Strategies DOI Creative Commons
Chitaranjan Mahapatra, Jineetkumar Gawad, Chandrakant Bonde

и другие.

Receptors, Год журнала: 2025, Номер 4(2), С. 9 - 9

Опубликована: Апрель 2, 2025

Bioelectric membrane potentials regulate cellular growth, differentiation, and movement. Disruptions in bioelectric signaling are strongly linked to cancer development, as abnormal ion channel activity can drive tumor progression. In breast cancer, dysfunction neuroreceptor-related pathways play significant roles the cell cycle, epithelial–mesenchymal transition, angiogenesis, inflammation, microenvironment, Neuroreceptors critical not only initiating advancing but also conferring resistance treatments. a key role, with dopamine receptor D2 activation reducing growth by 40% preclinical models, while serotonin has been shown promote transition (EMT), increasing invasiveness. Advances understanding these biological mechanisms could lead more cost-effective less invasive therapeutic strategies treat tumors. This review explores expanding evidence connecting focusing on neuroreceptor pharmacology transformative approach. Examining modulation of bioelectricity through influence progression integrating insights into development offers promising path for addressing treatment challenges improving precision managing aggressive subtypes.

Язык: Английский

A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment DOI Creative Commons

Aoling Huang,

Hao Xue, Ting Xie

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 15, 2025

With breast cancer being the most common tumor among women in world today, it is also leading cause of cancer-related deaths. Standard treatments include chemotherapy, surgery, endocrine therapy, and targeted therapy. However, heterogeneity, drug resistance, poor prognosis highlight an urgent need for further exploration its underlying mechanisms. Mitochondria, highly dynamic intracellular organelles, play a pivotal role maintaining cellular energy metabolism. Altered mitochondrial function plays critical various diseases, recent studies have elucidated pathophysiological mechanisms carcinogenesis. This review explores dysfunction pathogenesis assesses potential mitochondria-targeted therapies.

Язык: Английский

Процитировано

0
Bioelectric Membrane Potential and Breast Cancer: Advances in Neuroreceptor Pharmacology for Targeted Therapeutic Strategies DOI Creative Commons
Chitaranjan Mahapatra, Jineetkumar Gawad, Chandrakant Bonde

и другие.

Receptors, Год журнала: 2025, Номер 4(2), С. 9 - 9

Опубликована: Апрель 2, 2025

Bioelectric membrane potentials regulate cellular growth, differentiation, and movement. Disruptions in bioelectric signaling are strongly linked to cancer development, as abnormal ion channel activity can drive tumor progression. In breast cancer, dysfunction neuroreceptor-related pathways play significant roles the cell cycle, epithelial–mesenchymal transition, angiogenesis, inflammation, microenvironment, Neuroreceptors critical not only initiating advancing but also conferring resistance treatments. a key role, with dopamine receptor D2 activation reducing growth by 40% preclinical models, while serotonin has been shown promote transition (EMT), increasing invasiveness. Advances understanding these biological mechanisms could lead more cost-effective less invasive therapeutic strategies treat tumors. This review explores expanding evidence connecting focusing on neuroreceptor pharmacology transformative approach. Examining modulation of bioelectricity through influence progression integrating insights into development offers promising path for addressing treatment challenges improving precision managing aggressive subtypes.

Язык: Английский

Процитировано

0