The Essential Role of Mitochondrial Dynamics in Viral Infections
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 1955 - 1955
Опубликована: Фев. 24, 2025
Mitochondria
are
dynamic
organelles
that
play
crucial
roles
in
energy
production,
metabolic
balance,
calcium
homeostasis,
apoptosis,
and
innate
immunity,
key
determinants
of
cell
fate.
They
also
targets
for
viral
invasion
the
body.
Many
proteins
target
mitochondria,
controlling
mitochondrial
morphology,
metabolism,
immune
response,
thereby
achieving
evasion,
promoting
their
proliferation,
accelerating
infection
process.
Mitochondrial
quality
control
is
to
maintaining
normal
physiological
functions
homeostasis.
Dysregulation
dynamics
closely
related
development
many
diseases.
New
constantly
being
discovered.
Viruses
change
by
targeting
mitochondria
achieve
a
persistent
state
infection.
Currently,
understanding
during
limited.
Research
on
impact
provides
foundation
investigating
pathogenesis
infections,
disease
process,
identifying
potential
therapeutic
targets.
This
review
focuses
connection
between
priority
areas
research
virus-mediated
insight
into
regulation
viruses
explores
means
mitochondrial-mediated
treatment
Язык: Английский
Mitochondrial quality control and stress signaling pathways in the pathophysiology of cardio-renal diseases
Mitochondrion,
Год журнала:
2025,
Номер
unknown, С. 102040 - 102040
Опубликована: Апрель 1, 2025
Mitochondria
are
essential
organelles
for
cellular
function
and
have
become
a
broad
field
of
study.
In
cardio-renal
diseases,
it
has
been
established
that
mitochondrial
dysfunction
is
primary
mechanism
leading
to
these
pathologies.
Under
stress,
mitochondria
can
develop
stress
response
mechanisms
maintain
quality
control
(MQC)
functions.
contrast,
the
perturbation
associated
with
pathogenesis
several
diseases.
Thus,
targeting
specific
pathways
within
MQC
could
offer
therapeutic
avenue
protecting
integrity.
However,
related
signaling
in
axis
poorly
explored.
The
limitations
include
lack
reproducibility
experimental
models
disease,
incomplete
knowledge
molecules
generate
bidirectional
damage,
temporality
study
models.
Therefore,
we
believe
integration
all
those
limitations,
along
recent
advances
(i.e.,
mitophagy),
(e.g.,
integrated
response,
unfolded
protein
import),
pharmacology,
targeted
approaches
reveal
what
deregulation
like
provide
ideas
generating
strategies
seek
avoid
progression
Язык: Английский