Health care science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
Precision
medicine
(PM)
has
taken
center
stage
in
healthcare
since
the
completion
of
genomic
project.
Developed
countries
have
gradually
integrated
PM
into
mainstream
patient
management.
However,
Nigeria
still
grapples
with
wide
acceptance,
key
translational
research
and
implementation
PM.
This
study
sought
to
explore
knowledge
attitude
among
pharmacists
as
stakeholders
team.
A
cross-sectional
was
conducted
selected
tertiary
hospitals
across
country.
21-item
semi-structured
questionnaire
administered
by
hybrid
online
physical
methods
results
analyzed
Statistical
Package
for
Social
Sciences
Version
25.
Descriptive
statistics
were
used
summarize
data.
chi-square
test
employed
determine
association
sociodemographic
characteristics
population.
total
167
hospital
participated
study.
high
proportion
participants
are
familiar
artificial
intelligence
(91.75%),
Pharmacogenomics
(84.5%),
precision
(61%).
Overall,
38.9%
had
a
good
while
13.2%
poor
associated
terms.
The
level
did
not
correlate
significantly
gender
(X
2
=
3.21,
p
0.201),
age
5,
0.27),
marital
status
professional
6.85,
0.144).
most
important
value
is
ability
minimize
impact
disease
through
preventive
(49%)
large
portion
pursuing
or
actively
planning
pursue
additional
education
medicine.
There
highly
positive
toward
prospect
Nigeria.
Education
modules
this
field
recommended
do
holistic
terms
Also,
more
aimed
at
translating
clinical
practice
recommended.
Biology,
Год журнала:
2024,
Номер
13(10), С. 762 - 762
Опубликована: Сен. 25, 2024
Prostate
cancer
remains
a
significant
health
challenge,
being
the
most
prevalent
non-cutaneous
in
men
worldwide.
This
review
discusses
critical
advancements
biomarker
discovery
using
single-omics
and
multi-omics
approaches.
Multi-omics,
integrating
genomic,
transcriptomic,
proteomic,
metabolomic,
epigenomic
data,
offers
comprehensive
understanding
of
molecular
heterogeneity
prostate
cancer,
leading
to
identification
novel
biomarkers
therapeutic
targets.
holistic
approach
not
only
enhances
specificity
sensitivity
detection
but
also
supports
development
personalized
treatment
strategies.
Key
studies
highlighted
include
genes,
genetic
mutations,
peptides,
metabolites,
potential
through
analyses,
which
have
shown
promise
improving
management.
The
integration
clinical
practice
can
potentially
revolutionize
prognosis
treatment,
paving
way
for
precision
medicine.
underscores
importance
continued
research
application
overcome
current
challenges
diagnosis
therapy.
Pharmaceutics,
Год журнала:
2024,
Номер
16(7), С. 928 - 928
Опубликована: Июль 11, 2024
The
clinical
management
of
malignant
tumours
is
challenging,
often
leading
to
severe
adverse
effects
and
death.
Drug
resistance
(DR)
antagonises
the
effectiveness
treatments,
increasing
drug
dosage
can
worsen
therapeutic
index
(TI).
Current
efforts
overcome
DR
predominantly
involve
use
combinations,
including
applying
multiple
anti-cancerous
drugs,
employing
sensitisers,
which
are
chemical
agents
that
enhance
pharmacokinetics
(PK),
targeting
cellular
pathways
regulating
pertinent
membrane
transporters.
While
combining
compounds
may
lead
drug–drug
interactions
(DDI)
or
polypharmacy
effect,
sensitisers
permits
rapid
attainment
effective
treatment
dosages
at
disease
site
prevent
early
minimise
side
will
reduce
chance
DDI
as
lower
doses
required.
This
review
highlights
essential
TI
in
evaluating
for
cancer
discusses
lack
a
unified
standard
within
field.
Commonly
used
benefit–risk
assessment
criteria
summarised,
critical
exploration
current
pharmaceutical
industrial
sector
included.
Specifically,
this
leads
discussion
facilitate
improved
ratios
dose
toxic
directly
humans.
combination
sensitiser
molecules
might
see
additional
benefits
rekindle
those
drugs
failed
late-stage
trials
by
removal
detrimental
off-target
activities
through
doses.
combinations
potential
means
combat
DR.
evolution
on
reviewed.
Notably,
novel
binary
weapon
approach
introduced
new
opportunity
improve
TI.
emphasises
urgent
need
criterion
systematically
evaluate
safety
efficiency
practical
implementation
Health care science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
Precision
medicine
(PM)
has
taken
center
stage
in
healthcare
since
the
completion
of
genomic
project.
Developed
countries
have
gradually
integrated
PM
into
mainstream
patient
management.
However,
Nigeria
still
grapples
with
wide
acceptance,
key
translational
research
and
implementation
PM.
This
study
sought
to
explore
knowledge
attitude
among
pharmacists
as
stakeholders
team.
A
cross-sectional
was
conducted
selected
tertiary
hospitals
across
country.
21-item
semi-structured
questionnaire
administered
by
hybrid
online
physical
methods
results
analyzed
Statistical
Package
for
Social
Sciences
Version
25.
Descriptive
statistics
were
used
summarize
data.
chi-square
test
employed
determine
association
sociodemographic
characteristics
population.
total
167
hospital
participated
study.
high
proportion
participants
are
familiar
artificial
intelligence
(91.75%),
Pharmacogenomics
(84.5%),
precision
(61%).
Overall,
38.9%
had
a
good
while
13.2%
poor
associated
terms.
The
level
did
not
correlate
significantly
gender
(X
2
=
3.21,
p
0.201),
age
5,
0.27),
marital
status
professional
6.85,
0.144).
most
important
value
is
ability
minimize
impact
disease
through
preventive
(49%)
large
portion
pursuing
or
actively
planning
pursue
additional
education
medicine.
There
highly
positive
toward
prospect
Nigeria.
Education
modules
this
field
recommended
do
holistic
terms
Also,
more
aimed
at
translating
clinical
practice
recommended.
