Intake of S-Methylmethionine Alters Glucose Metabolism and Hepatic Gene Expression in C57BL/6J High-Fat-Fed Mice DOI Creative Commons
Mariana Buranelo Egea,

Gavin Pierce,

Neil F. Shay

и другие.

Foods, Год журнала: 2024, Номер 14(1), С. 34 - 34

Опубликована: Дек. 26, 2024

A diet containing foods that are sources of S-methylmethionine (SMM), and its use as a dietary supplement, have demonstrated beneficial health effects. Thus, the objective this work was to evaluate inclusion SMM supplement in C57BL/6J high-fat-fed mice verify whether compound alone would be responsible for these positive Mice were divided into three groups: LF (low-fat diet), HF (high-fat HF+SMM plus SMM), maintained 10 weeks with water food provided ad libitum. Body weight intake measured weekly, efficiency calculated. In addition, at week 9, fasting glucose and, after necropsy, 10, liver, inguinal adipose, kidney weights measured; triglycerides, histology, liver gene expression, serum insulin, MCP-1 levels also determined. Final body weight, average gain, liver/body group showed significant difference group. HF+SMM-fed show improved regulation metabolism, by assessment glucose, insulin concentration, HOMA-IR, compared HF-fed Liver triglycerides no differences between fed groups. By Sult1e1, Phlda1, Ciart, we hypothesized administration may regulated xenobiotic, circadian rhythm pathways.

Язык: Английский

Is Measuring BMI and Waist Circumference as Good in Assessing Insulin Resistance as Using Bioelectrical Impedance to Measure Total Body Fat and Visceral Fat? DOI Creative Commons

María Gordito Soler,

Pedro Juan Tárraga López, Ángel Arturo López‐González

и другие.

Diabetology, Год журнала: 2025, Номер 6(4), С. 32 - 32

Опубликована: Апрель 17, 2025

Background: Insulin resistance (IR) is a metabolic disorder linked to type 2 diabetes and cardiovascular diseases. Visceral fat better predictor of IR than BMI waist circumference due its inflammatory impact. Methods such as DEXA bioimpedance (BIA) estimate body fat, while scales METS-IR, SPISE, TyG assess risk. This study analyzes the utility visceral measured by BIA compared other indicators. Methods: A cross-sectional was conducted on 8590 workers in Balearic Islands, analyzing anthropometric, clinical, analytical variables. Body were bioimpedance, insulin assessed using TyG. ROC curves used evaluate predictive value BMI, WC, fat. Results: The areas under curve (AUCs) highest for high particularly women (>0.97), indicating excellent performance. showed lowest AUC, especially men. AUC all scales. Youden’s indices with good capacity, low values, limiting predicting resistance. Conclusions: Measuring superior or WC estimating

Язык: Английский

Процитировано

0
Intake of S-Methylmethionine Alters Glucose Metabolism and Hepatic Gene Expression in C57BL/6J High-Fat-Fed Mice DOI Creative Commons
Mariana Buranelo Egea,

Gavin Pierce,

Neil F. Shay

и другие.

Foods, Год журнала: 2024, Номер 14(1), С. 34 - 34

Опубликована: Дек. 26, 2024

A diet containing foods that are sources of S-methylmethionine (SMM), and its use as a dietary supplement, have demonstrated beneficial health effects. Thus, the objective this work was to evaluate inclusion SMM supplement in C57BL/6J high-fat-fed mice verify whether compound alone would be responsible for these positive Mice were divided into three groups: LF (low-fat diet), HF (high-fat HF+SMM plus SMM), maintained 10 weeks with water food provided ad libitum. Body weight intake measured weekly, efficiency calculated. In addition, at week 9, fasting glucose and, after necropsy, 10, liver, inguinal adipose, kidney weights measured; triglycerides, histology, liver gene expression, serum insulin, MCP-1 levels also determined. Final body weight, average gain, liver/body group showed significant difference group. HF+SMM-fed show improved regulation metabolism, by assessment glucose, insulin concentration, HOMA-IR, compared HF-fed Liver triglycerides no differences between fed groups. By Sult1e1, Phlda1, Ciart, we hypothesized administration may regulated xenobiotic, circadian rhythm pathways.

Язык: Английский

Процитировано

0