Toxicity of airborne nanoparticles: Facts and challenges

Environment International, Год журнала: 2024, Номер 190, С. 108889 - 108889

Опубликована: Июль 18, 2024

Air pollution is one of the most severe environmental health hazards, and airborne nanoparticles (diameter <100 nm) are considered particularly hazardous to human health. They produced by various sources such as internal combustion engines, wood biomass burning, fuel natural gas combustion, their origin, among other parameters, determines intrinsic toxicity for reasons that not yet fully understood. Many constituents toxic or at least hazardous, including polycyclic aromatic hydrocarbons (PAHs) heavy metal compounds, in addition gaseous pollutants present aerosol fraction, NOx, SO2, ozone. All these compounds can cause oxidative stress, mitochondrial damage, inflammation lungs tissues, cellular organelles. Epidemiological investigations concluded may affect respiratory, cardiovascular, nervous systems. Moreover, particulate matter has been linked an increased risk lung cancer, a carcinogenic effect related DNA but inflammatory response pollutants, which release cytokines promotes proliferation pre-existing mutated cancer cells. The mechanisms behind be investigated experimentally using cell cultures animal models. Methods gathering have explored, standardized protocols needed ensure samples accurately represent chemical mixtures environment. Toxic studied models, designing realistic exposure settings challenging. air–liquid interface (ALI) system directly exposes cells, mimicking particle inhalation into lungs. Continuous research monitoring essential understanding effects developing active strategies mitigate risks

Язык: Английский

---

Evaluation of organ developmental toxicity of environmental toxicants using zebrafish embryos

Molecules and Cells, Год журнала: 2024, Номер 47(12), С. 100144 - 100144

Опубликована: Ноя. 1, 2024

There is increasing global concern about environmental pollutants, such as heavy metals, plastics, pharmaceuticals, personal care products, and pesticides, which have been detected in a variety of environments are likely to be exposed nontarget organisms, including humans. Various animal models utilized for toxicity assessment, zebrafish particularly valuable studying the various compounds owing their similarity other aquatic organisms 70% genetic Their development easy observe, transgenic organs heart, liver, blood vessels, nervous system enable efficient studies organ-specific toxicity. This suggests that tool evaluating specific forecasting potential impacts on species. review describes organ caused by toxic substances mechanisms zebrafish.

Язык: Английский

---

Cellular mechanisms underlying toxic effects of pesticides on mammary gland

Molecular & Cellular Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Язык: Английский

---

Fenoxycarb induces cardiovascular, hepatic, and pancreatic toxicity in zebrafish larvae via ROS production, excessive inflammation, and apoptosis

The Science of The Total Environment, Год журнала: 2025, Номер 969, С. 178957 - 178957

Опубликована: Фев. 26, 2025

Язык: Английский

---

Environmental and toxicological effects of carbamate pesticides on zebrafish embryogenesis

Molecular & Cellular Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Язык: Английский

---

Unraveling ER dimerization dynamics in endocrine disruption based on a BRET-focused approach

Animal Cells and Systems, Год журнала: 2025, Номер 29(1), С. 282 - 295

Опубликована: Апрель 28, 2025

Endocrine-disrupting chemicals (EDCs) are exogenous compounds that interact with the estrogen receptor (ER), thereby disrupting estrogen-mediated signaling. In a previous study, we employed bioluminescence resonance energy transfer (BRET) system to assess ER dimerization for detecting EDCs. To further determine whether BRET assay could be used independently identify EDCs, investigated ER-EDC interactions before and after dimerization. Results from isothermal titration calorimetry (ITC) dynamic light scattering (DLS) revealed can mediated by Consequently, proved effective in clarifying its relevance EDC-induced signaling disruption. Additionally, examine transcriptional changes, performed chromatin immunoprecipitation sequencing (ChIP-seq), followed gene ontology (GO) analysis. These analyses demonstrated EDCs affect various pathways, including those involved antibody-dependent cytotoxicity, bone morphogenetic protein (BMP) cardiac induction, hepatocyte growth factor Overall, this study elucidates molecular mechanisms which influence findings highlight utility of BRET-based EDC detection contribute deeper understanding systemic effects on endocrine

Язык: Английский

---

Brief guide to Caenorhabditis elegans survival assays

Molecules and Cells, Год журнала: 2025, Номер unknown, С. 100232 - 100232

Опубликована: Май 1, 2025

Язык: Английский

---

The associations of the concentrations of toxic metals (including metalloid) in blood and follicular fluid with the risk of diminished ovarian reserve

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 286, С. 117144 - 117144

Опубликована: Окт. 16, 2024

Язык: Английский

---

In vitro and in silico assessment of cytotoxicity of dinitramine via calcium dysregulation and mitochondrial dysfunction in bovine mammary glands

Pesticide Biochemistry and Physiology, Год журнала: 2024, Номер 205, С. 106152 - 106152

Опубликована: Сен. 25, 2024

Язык: Английский

---