Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

Nature Metabolism, Год журнала: 2022, Номер 4(6), С. 651 - 662

Опубликована: Июнь 27, 2022

Язык: Английский

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The role of BCL-2 family proteins in regulating apoptosis and cancer therapy

Frontiers in Oncology, Год журнала: 2022, Номер 12

Опубликована: Окт. 12, 2022

Apoptosis, as a very important biological process, is response to developmental cues or cellular stress. Impaired apoptosis plays central role in the development of cancer and also reduces efficacy traditional cytotoxic therapies. Members B-cell lymphoma 2 (BCL-2) protein family have pro- anti-apoptotic activities been studied intensively over past decade for their importance regulating apoptosis, tumorigenesis, responses anticancer therapy. Since inflammatory induced by apoptosis-induced cell death small, at present, drugs targeting has attracted more attention. Consequently, focus this review summarize current research on BCL-2 proteins proteins. Additionally, mechanism was explored. All findings indicate potential therapy cancer.

Язык: Английский

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Understanding mechanisms of antioxidant action in health and disease

Nature Reviews Molecular Cell Biology, Год журнала: 2023, Номер 25(1), С. 13 - 33

Опубликована: Сен. 15, 2023

Язык: Английский

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Superoxide Radicals in the Execution of Cell Death

Antioxidants, Год журнала: 2022, Номер 11(3), С. 501 - 501

Опубликована: Март 4, 2022

Superoxide is a primary oxygen radical that produced when an molecule receives one electron. dismutase (SOD) plays role in the cellular defense against oxidative insult by ROS. However, resulting hydrogen peroxide still reactive and, presence of free ferrous iron, may produce hydroxyl radicals and exacerbate diseases. Polyunsaturated fatty acids are preferred target radicals. Ferroptosis, type necrotic cell death induced lipid peroxides has attracted considerable interest because its pathogenesis many Radical electrons, namely those released from mitochondrial electron transfer complexes, enzymatic reactions, such as lipoxygenases, appear to cause peroxidation. While GPX4 most potent anti-ferroptotic enzyme known reduce alcohols, other antioxidative enzymes also indirectly involved protection ferroptosis. Moreover, several low molecular weight compounds include α-tocopherol, ascorbate, nitric oxide efficiently neutralize thereby suppressing The removal electrons early stages importance protecting ferroptosis diseases related stress.

Язык: Английский

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ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways

Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 23

Опубликована: Окт. 19, 2022

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range molecules with oxidizing properties known as ROS. Despite those being implied negatively in aging and numerous diseases, their key role signaling evident. ROS control several biological processes such inflammation, proliferation, cell death. The redox underlying these events one characteristic the new generation scientists aimed at defining environment. potential, which includes balance sources antioxidant system, implies an important target for understanding cells’ fate derived from signaling. In this review, we summarized chemical, balance, signaling, implications aging.

Язык: Английский

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Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Июль 21, 2023

Diabetic nephropathy (DN) often leads to end-stage renal disease. Oxidative stress demonstrates a crucial act in the onset and progression of DN, which triggers various pathological processes while promoting activation inflammation forming vicious oxidative stress-inflammation cycle that induces podocyte injury, extracellular matrix accumulation, glomerulosclerosis, epithelial-mesenchymal transition, tubular atrophy, proteinuria. Conventional treatments for DN have limited efficacy. Polyphenols, as antioxidants, are widely used with multiple targets fewer adverse effects. This review reveals stress-associated led damage cells, including podocytes, endothelial mesangial epithelial cells. It potent antioxidant anti-inflammatory properties by targeting Nrf2, SIRT1, HMGB1, NF-κB, NLRP3 polyphenols, quercetin, resveratrol, curcumin, phenolic acid. However, there remains long way comprehensive understanding molecular mechanisms applications clinical therapy polyphenols.

Язык: Английский

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Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 7910 - 7910

Опубликована: Апрель 26, 2023

Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from general pathology perspective, particularly with regard atherogenesis patterns in context both canonical and non-classical inflammation types. In review, we analyze various typical phenomena outcomes cellular pro-inflammatory stress atherosclerosis, as well role endothelial dysfunction local systemic manifestations low-grade inflammation. We also present features immune development productive stable unstable plaques, along their similarities differences compared There are numerous factors that act inducers inflammatory process including vascular endothelium aging, metabolic dysfunctions, autoimmune, some cases, infectious damage factors. Life-critical complications such cardiogenic shock severe strokes, associated acute hyperinflammation. Additionally, critical atherosclerotic ischemia lower extremities induces paracoagulation chronic Conversely, sepsis, other conditions, diseases contribute atherogenesis. summary, can be characterized an independent form inflammation, sharing but having fundamental variants (classic vasculitis).

Язык: Английский

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Fundamentals of redox regulation in biology

Nature Reviews Molecular Cell Biology, Год журнала: 2024, Номер 25(9), С. 701 - 719

Опубликована: Апрель 30, 2024

Язык: Английский

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Drug-induced oxidative stress in cancer treatments: Angel or devil?

Redox Biology, Год журнала: 2023, Номер 63, С. 102754 - 102754

Опубликована: Май 18, 2023

Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one the most significant biological events cancer progression. Cancer cells generally represent a higher level, which suggests dual therapeutic strategy by regulating status (i.e., pro-oxidant therapy and/or antioxidant therapy). Indeed, exhibits great anti-cancer capability, attributing to accumulation within cells, whereas restore homeostasis has been claimed fail several clinical practices. Targeting vulnerability pro-oxidants capable generating excessive reactive oxygen species (ROS) surfaced an important strategy. However, multiple adverse effects caused indiscriminate attacks uncontrolled drug-induced OS on normal tissues and drug-tolerant capacity some certain greatly limit their further applications. Herein, we review representative oxidative drugs summarize side organs, emphasizing that seeking balance between damage value exploiting next-generation OS-based chemotherapeutics.

Язык: Английский

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Unraveling mitochondria‐targeting reactive oxygen species modulation and their implementations in cancer therapy by nanomaterials

Exploration, Год журнала: 2023, Номер 3(2)

Опубликована: Апрель 1, 2023

Abstract Functional subcellular organelle mitochondria are emerging as a crucial player and driver of cancer. For maintaining the sites cellular respiration, experience production, accumulation reactive oxygen species (ROS) underlying oxidative damage in electron transport chain carriers. Precision medicine targeting can change nutrient availability redox homeostasis cancer cells, which might represent promising strategy for suppressing tumor growth. Herein, this review highlights how modification capable manipulating nanomaterials ROS generation strategies influence or compensate state mitochondrial homeostasis. We propose foresight to guide research innovation with an overview seminal work discuss future challenges our perspective on commercialization novel mitochondria‐targeting agents.

Язык: Английский

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