Probiotics
as
green
inputs
have
been
reported
to
regulate
metabolism
and
immunity
of
fish.
However,
the
mechanisms
by
which
probiotics
improve
growth
health
fish
are
unclear.
Therefore,
aim
this
study
was
investigate
effect
Bacillus
subtilis
HGCC-1,
an
indigenous
probiotic
isolated
from
fish,
on
performance,
host
lipid
metabolism,
liver
inflammation
gut
microbiota
golden
pompano.
160,000
pompanos
with
initial
body
weight
93.6
±
5.0
g
randomly
assigned
two
dietary
groups:
Control
HGCC-1
(control
diet
supplemented
0.3
g/kg
fermentation
product),
after
three
weeks
feeding,
26
were
collected
each
group
for
microbiome
phenotype
analysis.
Dietary
supplementation
significantly
promoted
performance
(P
<
0.05)
enhanced
feed
utilization.
Besides,
improved
alleviated
hepatic
steatosis
inflammation.
Furthermore,
intestinal
absorption,
utilization
fat
improving
uptake/transport
fatty
acid
β-oxidation
provide
energy,
reduced
TG
level
0.05),
may
be
potential
mechanism
HGCC-1-mediated
promotion.
Finally,
altered
structure
function
leading
enrichment
beneficial
taxa
such
0.0001)
increased
ratio
"Functional
Group
2/Functional
1"
=
0.00092).
Interestingly,
linked
traits
(Spearman,
P
while
abundance
correlated
serum
in
R
0.47,
0.00091),
suggesting
a
role
mediated
metabolism.
In
summary,
promotes
alleviate
enhances
via
regulating
pompano,
ultimately
showed
health.
Nature Reviews Drug Discovery,
Год журнала:
2022,
Номер
21(4), С. 283 - 305
Опубликована: Янв. 14, 2022
Fatty
acids
are
essential
for
survival,
acting
as
bioenergetic
substrates,
structural
components
and
signalling
molecules.
Given
their
vital
role,
cells
have
evolved
mechanisms
to
generate
fatty
from
alternative
carbon
sources,
through
a
process
known
de
novo
lipogenesis
(DNL).
Despite
the
importance
of
DNL,
aberrant
upregulation
is
associated
with
wide
variety
pathologies.
Inhibiting
core
enzymes
including
citrate/isocitrate
carrier
(CIC),
ATP-citrate
lyase
(ACLY),
acetyl-CoA
carboxylase
(ACC)
acid
synthase
(FAS),
represents
an
attractive
therapeutic
strategy.
challenges
related
efficacy,
selectivity
safety,
several
new
classes
synthetic
DNL
inhibitors
entered
clinical-stage
development
may
become
foundation
class
therapeutics.
De
(DNL)
maintenance
whole-body
cellular
homeostasis,
but
pathway
broad
range
conditions,
cardiovascular
disease,
metabolic
disorders
cancers.
Here,
Steinberg
colleagues
provide
overview
physiological
pathological
roles
assess
strategies
agents
currently
in
therapeutically
target
them.
European Journal of Inflammation,
Год журнала:
2023,
Номер
21
Опубликована: Янв. 30, 2023
Pancreatic
β-cells
produce
and
secrete
insulin
to
maintain
blood
glucose
levels
within
a
narrow
range.
Defects
in
the
function
mass
of
play
significant
role
development
progression
diabetes.
Increased
β-cell
deficiency
apoptosis
are
observed
pancreatic
islets
patients
with
type
2
At
an
early
stage,
adapt
resistance,
their
secretion
increases,
but
they
eventually
become
exhausted,
decreases.
Various
causal
factors,
such
as
high
glucose,
free
fatty
acids,
inflammatory
cytokines,
islet
amyloid
polypeptides,
contribute
impairment
function.
Therefore,
maintenance
is
logical
approach
for
treatment
prevention
In
this
review,
we
provide
overview
these
risk
factors
loss
associated
mechanisms.
A
better
understanding
molecular
mechanisms
underlying
will
opportunity
identify
novel
therapeutic
targets
Biomarker Research,
Год журнала:
2023,
Номер
11(1)
Опубликована: Июнь 30, 2023
Abstract
Cancer
exerts
a
multitude
of
effects
on
metabolism,
including
the
reprogramming
cellular
metabolic
pathways
and
alterations
in
metabolites
that
facilitate
inappropriate
proliferation
cancer
cells
adaptation
to
tumor
microenvironment.
There
is
growing
body
evidence
suggesting
aberrant
play
pivotal
roles
tumorigenesis
metastasis,
have
potential
serve
as
biomarkers
for
personalized
therapy.
Importantly,
high-throughput
metabolomics
detection
techniques
machine
learning
approaches
offer
tremendous
clinical
oncology
by
enabling
identification
cancer-specific
metabolites.
Emerging
research
indicates
circulating
great
promise
noninvasive
detection.
Therefore,
this
review
summarizes
reported
abnormal
cancer-related
last
decade
highlights
application
liquid
biopsy,
specimens,
technologies,
methods,
challenges.
The
provides
insights
into
promising
tool
applications.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
170, С. 115586 - 115586
Опубликована: Дек. 1, 2023
Metabolic
diseases,
featured
with
dysregulated
energy
homeostasis,
have
become
major
global
health
challenges.
Patients
metabolic
diseases
high
probability
to
manifest
multiple
complications
in
lipid
metabolism,
e.g.
obesity,
insulin
resistance
and
fatty
liver.
Therefore,
targeting
the
hub
genes
metabolism
may
systemically
ameliorate
along
complications.
Stearoyl-CoA
desaturase
1(SCD1)
is
a
key
enzyme
that
desaturates
saturated
acids
(SFAs)
derived
from
de
novo
lipogenesis
or
diet
generate
monounsaturated
(MUFAs).
SCD1
maintains
tissue
homeostasis
by
responding
to,
integrating
layers
of
endogenous
stimuli,
which
mediated
synthesized
MUFAs.
It
critically
regulates
myriad
physiological
processes,
including
development,
autophagy,
tumorigenesis
inflammation.
Aberrant
transcriptional
epigenetic
activation
AMPK/ACC,
SIRT1/PGC1α,
NcDase/Wnt,
etc,
causes
aberrant
accumulation,
thereby
promoting
progression
non-alcoholic
liver,
diabetes
cancer.
This
review
assesses
integrative
mechanisms
(patho)physiological
functions
inflammation
autophagy.
For
translational
perspective,
potent
inhibitors
been
developed
treat
various
types
We
thus
discuss
multidisciplinary
advances
greatly
accelerate
development
new
inhibitors.
In
conclusion,
besides
cancer
treatment,
serve
as
promising
target
combat
simultaneously.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
168, С. 115670 - 115670
Опубликована: Окт. 13, 2023
Diabetic
nephropathy
(DN)
is
a
severe
complication
of
diabetes
mellitus,
posing
significant
challenges
in
terms
early
prevention,
clinical
diagnosis,
and
treatment.
Consequently,
it
has
emerged
as
major
contributor
to
end-stage
renal
disease.
The
glomerular
filtration
barrier,
composed
podocytes,
endothelial
cells,
the
basement
membrane,
plays
vital
role
maintaining
function.
Disruptions
podocyte
function,
including
hypertrophy,
shedding,
reduced
density,
apoptosis,
can
impair
integrity
resulting
elevated
proteinuria,
abnormal
rate,
increased
creatinine
levels.
Hence,
recent
research
increasingly
focused
on
injury
DN,
with
growing
emphasis
exploring
therapeutic
interventions
targeting
injury.
Studies
have
revealed
that
factors
such
lipotoxicity,
hemodynamic
abnormalities,
oxidative
stress,
mitochondrial
dysfunction,
impaired
autophagy
contribute
This
review
aims
summarize
underlying
mechanisms
DN
provide
an
overview
current
status
regarding
experimental
drugs
DN.
findings
presented
herein
may
offer
potential
targets
strategies
for
management
associated
