Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(13), С. 6787 - 6802
Опубликована: Март 21, 2024
Tryptophan
(Trp)
is
an
essential
amino
acid
which
unable
to
be
synthesized
in
the
body.
Main
sources
of
Trp
are
uptake
foods
such
as
oats
and
bananas.
In
this
review,
we
describe
status
current
dietary
consumption,
metabolic
pathways
nutritional
characteristics
Trp,
well
its
ingestion
downstream
metabolites
for
maintaining
body
health
safety.
This
review
also
summarizes
recent
advances
metabolism,
particularly
5-HT,
KYN,
AhR
activation
pathways,
revealing
that
endogenous
host
not
only
differentially
affected
but
closely
linked
health.
More
attention
should
paid
targeting
specific
utilizing
food
molecules
probiotics
manipulating
metabolism.
However,
complexity
microbiota–host
interactions
requires
further
exploration
precisely
refine
targets
innovating
gut
microbiota-targeted
diagnostic
approaches
informing
subsequent
studies
targeted
treatments
diseases.
FEBS Journal,
Год журнала:
2023,
Номер
291(3), С. 412 - 429
Опубликована: Май 2, 2023
Amino
acids
act
as
versatile
nutrients
driving
cell
growth
and
survival,
especially
in
cancer
cells.
acid
metabolism
comprises
numerous
metabolic
networks
is
closely
linked
with
intracellular
redox
balance
epigenetic
regulation.
Reprogrammed
amino
has
been
recognized
a
ubiquitous
feature
tumour
This
review
outlines
the
of
several
primary
cells
highlights
pivotal
role
sustaining
homeostasis
regulating
modification
response
to
oxidative
genetic
stress
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Май 16, 2024
Abstract
Maturing
immunometabolic
research
empowers
immune
regulation
novel
approaches.
Progressive
metabolic
adaptation
of
tumor
cells
permits
a
thriving
microenvironment
(TME)
in
which
always
lose
the
initial
killing
capacity,
remains
an
unsolved
dilemma
even
with
development
checkpoint
therapies.
In
recent
years,
many
studies
on
immunometabolism
have
been
reported.
The
may
facilitate
anti-tumor
immunotherapy
from
recurrent
crosstalk
between
metabolism
and
immunity.
Here,
we
discuss
clinical
core
signaling
pathways
their
inhibitors
or
agonists,
as
well
specific
functions
these
regulating
immunity
metabolism,
some
identified
checkpoints.
Understanding
comprehensive
advances
helps
to
revise
status
quo
cancer
treatment.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
15(1), С. 424 - 437
Опубликована: Июнь 25, 2024
The
development
of
anticancer
drugs
to
treat
triple-negative
breast
cancer
(TNBC)
is
an
ongoing
challenge.
Immunogenic
cell
death
(ICD)
has
garnered
considerable
interest
worldwide
as
a
promising
synergistic
modality
for
chemoimmunotherapy.
However,
only
few
or
treatment
modalities
can
trigger
ICD
response
and
none
them
exert
clinical
effect
against
TNBC.
Therefore,
new
agents
with
potentially
effective
chemoimmunotherapeutic
are
required.
In
this
study,
five
cyclometalated
Ir(III)
complexes
containing
isoquinoline
alkaloid
CˆN
ligands
were
designed
synthesized.
Among
them,
Ir-1
exhibited
the
highest
in
vitro
cytotoxicity.
Mechanistically,
could
autophagy-dependent
ferroptosis
subsequent
ferroptosis-dependent
well
indoleamine
2,3-dioxygenase
(IDO)
inhibition
via
reactive
oxygen
species
(ROS)-mediated
endoplasmic
reticulum
(ER)
stress
MDA-MB-231
cells.
When
immunocompetent
BALB/c
mice
vaccinated
Ir-1-treated
dying
TNBC
cells,
antitumor
CD8+
T-cell
Foxp3+
depletion
induced,
resulting
long-lasting
immunity
Moreover,
combination
therapy
anti-PD1
substantially
augment
vivo
therapeutic
effects.
Based
on
these
results,
candidate
chemoimmunotherapy
its
effects
mediated
synergistically
induction
IDO
blockage.
Journal of Cellular and Molecular Medicine,
Год журнала:
2025,
Номер
29(2)
Опубликована: Янв. 1, 2025
Postmenopausal
osteoporosis
(PMOP)
is
a
chronic
systemic
bone
metabolism
disorder.
Promotion
in
the
patterns
of
human
marrow
mesenchymal
stem
cells
(hBMSCs)
differentiation
towards
osteoblasts
contributes
to
alleviating
osteoporosis.
Aucubin,
natural
compound
isolated
from
well-known
herbal
medicine
Eucommia,
was
previously
shown
possess
various
pharmacological
effects.
However,
its
effects
on
hBMSCs
PMOP
patients
are
unknown.
The
aim
this
present
research
investigate
impact
and
underlying
process
aucubin
cell
proliferation
osteogenic
patients.
ability
inhibit
ferroptosis
induced
by
erastin
detected;
ROS
production,
ferrous
ion
levels,
SOD,
MDA,
GPX
activities
were
tested
using
commercial
kits.
Next,
ALP
staining,
ARS
RT-qPCR,
RNA-sequencing,
Western
blot
applied
for
determining
mRNA
protein
expression
levels
associated
with
osteogenesis
hBMSCs.
study
also
explored
involvement
BMP2/Smads
signalling
promoting
evaluated
intervention
an
ovariectomised
rat
model.
results
indicated
that
significantly
inhibited
generation
oxidative
stress
protected
against
Additionally,
facilitated
activating
BMP2/SMADs
pathway
attenuated
progression
OVX
rats,
suggesting
potential
therapeutic
benefit
postmenopausal
(PMOP).
Frontiers in Oncology,
Год журнала:
2025,
Номер
14
Опубликована: Янв. 22, 2025
The
pivotal
role
of
metabolic
reprogramming
in
cancer-related
drug
resistance,
through
the
tryptophan-catabolized
kynurenine
pathway
(KP),
has
been
particularly
underscored
recent
research.
This
pathway,
driven
by
indoleamine
2,3-dioxygenase
1
(IDO1),
facilitates
immune
evasion
and
promotes
tumor
progression
fostering
an
immunosuppressive
environment.
In
Phase
III
investigation
combination
IDO1
inhibition
with
checkpoint
inhibitors
(ICIs),
therapy
was
not
efficacious.
this
review,
we
revisit
current
advances,
explore
future
directions,
emphasize
importance
dual
KP
rate-limiting
enzymes
tryptophan
2,3-dioxygenase-2
(TDO2)
appropriate
patient
populations.
We
propose
that
may
maximize
therapeutic
potential
inhibition.
Additionally,
delve
into
complex
cellular
interactions
cancer
dependencies
within
microenvironment
(TME).
Insights
from
preclinical
studies,
clinical
trials,
promising
combinations
will
be
discussed
to
elucidate
promote
a
clear
path
forward
for
direction
research
outcomes.
Seminars in Immunopathology,
Год журнала:
2022,
Номер
45(2), С. 163 - 186
Опубликована: Сен. 26, 2022
Abstract
Tumour
microenvironment
is
a
complex
ecosystem
in
which
myeloid
cells
are
the
most
abundant
immune
elements.
This
cell
compartment
composed
by
different
types,
including
neutrophils,
macrophages,
dendritic
cells,
and
monocytes
but
also
unexpected
populations
with
immunosuppressive
pro-tumour
roles.
Indeed,
release
of
tumour-derived
factors
influences
physiological
haematopoiesis
producing
unconventional
tolerogenic
functions
such
as
myeloid-derived
suppressor
cells.
These
not
only
support
escape
directly
assist
tumour
invasion
trough
non-immunological
activities.
It
therefore
surprising
that
these
subsets
considerably
impact
progression
cancer
therapy
resistance,
immunotherapy,
being
investigated
potential
targets
for
developing
new
era
therapy.
In
this
review,
we
discuss
emerging
strategies
able
to
modulate
functional
activity
tumour-supporting
subverting
their
accumulation,
recruitment,
survival,
functions.
innovative
approaches
will
help
develop
innovative,
or
improve
existing,
treatments.
