Molecular Cell, Год журнала: 2023, Номер 84(1), С. 23 - 33
Опубликована: Ноя. 28, 2023
Язык: Английский
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114993 - 114993
Опубликована: Июнь 9, 2023
Cardiovascular disease (CVD) is a major contributor to increasing morbidity and mortality worldwide seriously threatens human health life. Cardiomyocyte death considered the pathological basis of various CVDs, including myocardial infarction, heart failure, aortic dissection. Multiple mechanisms, such as ferroptosis, necrosis, apoptosis, contribute cardiomyocyte death. Among them, ferroptosis an iron-dependent form programmed cell that plays vital role in physiological processes, from development aging immunity CVD. The dysregulation has been shown be closely associated with CVD progression, yet its underlying mechanisms are still not fully understood. In recent years, growing amount evidence suggests non-coding RNAs (ncRNAs), particularly microRNAs, long RNAs, circular involved regulation thus affecting progression. Some ncRNAs also exhibit potential value biomarker and/or therapeutic target for patients this review, we systematically summarize findings on their We focus clinical applications diagnostic prognostic biomarkers well targets treatment. DATA AVAILABILITY: No new data were created or analyzed study. Data sharing applicable article.
Язык: Английский
Процитировано
51
Ageing Research Reviews, Год журнала: 2023, Номер 91, С. 102035 - 102035
Опубликована: Авг. 23, 2023
Ferroptosis is an iron- and lipid peroxidation (LPO)-mediated programmed cell death type. Recently, mounting evidence has indicated the involvement of ferroptosis in neurodegenerative diseases, especially Alzheimer's disease (AD), Parkinson's (PD), multiple sclerosis (MS), amyotrophic lateral (ALS), Huntington's (HD), so on. Treating presents opportunities as well challenges for diseases. This review provides a comprehensive overview underlying mechanisms that contribute to occurrence ferroptosis, their implications pathogenesis advancement major disorders. Meanwhile, we summarize interaction between other types diseases contribution corresponding drug development. In addition, specifically recent advances developing therapeutic means targeting these which may guide future approaches effective management devastating medical conditions.
Язык: Английский
Процитировано
50
JHEP Reports, Год журнала: 2023, Номер 5(5), С. 100695 - 100695
Опубликована: Фев. 3, 2023
Oxidative stress-mediated ferroptosis and macrophage-related inflammation play an important role in various liver diseases. Here, we explored if how hepatocyte regulates macrophage stimulator of interferon genes (STING) activation the development spontaneous damage, fibrosis, tumorigenesis.We used a transforming growth factor-beta-activated kinase 1 (TAK1) deficiency-induced model tumorigenesis to investigate its impact on STING signalling. Primary hepatocytes macrophages were for vitro experiments.Significant injury increased numbers intrahepatic M1 found hepatocyte-specific TAK1-deficient (TAK1ΔHEP) mice, peaking at 4 weeks gradually decreasing 8 12 weeks. Meanwhile, signalling was observed livers from TAK1ΔHEP mice had decreased Treatment with inhibitor promoted M2 polarisation alleviated injury, tumour burden. TAK1 deficiency exacerbated iron metabolism high-iron diet. Moreover, consistent results single-cell RNA-Seq dataset, demonstrated oxidative response hepatocellular ferroptosis, which could be inhibited by reactive oxygen species scavenging. Suppression ferrostatin-1 signalling, leading attenuated fibrosis reduced Mechanistically, serum levels 8-hydroxydeoxyguanosine detected suppressed inhibition. antibody mice.Hepatocellular ferroptosis-derived DNA damage promotes facilitate tumorigenesis. Inhibition may represent novel therapeutic approach prevention chronic disease.The precise mechanism progression remains unclear. Herein, show that deletion caused carcinoma.
Язык: Английский
Процитировано
48
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114312 - 114312
Опубликована: Май 19, 2023
Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by massive loss of specific neurons. It is a progressive disabling, severe and fatal complex disease. Due to its pathogenesis limitations clinical treatment strategies, it poses serious medical challenge burden worldwide. The AD not clear, potential biological mechanisms include aggregation soluble amyloid form insoluble plaques, abnormal phosphorylation tau protein formation intracellular neurofibrillary tangles (NFT), neuroinflammation, ferroptosis, oxidative stress metal ion disorders. Among them, ferroptosis newly discovered programmed cell death induced iron-dependent lipid peroxidation reactive oxygen species. Recent studies have shown that closely related AD, but the mechanism remains unclear. may be iron metabolism, amino acid metabolism affecting accumulation ions. Some chelating agents (deferoxamine, deferiprone), chloroiodohydroxyquine derivatives, antioxidants (vitamin E, lipoic acid, selenium), derivatives Fer-1, tet, etc. been in animal effective exert neuroprotective effects. This review summarizes regulation natural plant products on order provide reference information for future research development inhibitors.
Язык: Английский
Процитировано
48
Molecular Cell, Год журнала: 2023, Номер 84(1), С. 23 - 33
Опубликована: Ноя. 28, 2023
Язык: Английский
Процитировано
46