Phytomedicine, Год журнала: 2024, Номер 136, С. 156303 - 156303
Опубликована: Дек. 4, 2024
Abnormal antioxidant capacity in cancer cells is intimately linked to tumor aggressiveness. Modulating oxidative stress status and inhibiting ferroptosis represents a novel anticancer therapeutic strategy. STAM Binding Protein Like 1 (STAMBPL1), deubiquitinase, implicated various malignancies, yet its function potential for cholangiocarcinoma (CCA) remains unexplored.
Язык: Английский
Frontiers in Oncology, Год журнала: 2024, Номер 14
Опубликована: Дек. 4, 2024
The SMAD-specific E3 ubiquitin protein ligase 2 (SMURF2) has emerged as a critical regulator in cancer biology, modulating the stability of Hypoxia-Inducible Factor 1-alpha (HIF1α) and influencing network hypoxia-driven pathways within tumor microenvironment (TME). SMURF2 targets HIF1α for ubiquitination subsequent proteasomal degradation, disrupting hypoxic responses that promote cell survival, metabolic reprogramming, angiogenesis, resistance to therapy. Beyond its role regulation, exerts extensive control over cellular processes central progression, including chromatin remodeling, DNA damage repair, ferroptosis, stress responses. Notably, SMURF2's ability ferroptotic death through GSTP1 degradation offers an alternative pathway overcome apoptosis resistance, expanding therapeutic options refractory cancers. This review delves into multifaceted interactions between HIF1α, emphasizing how their interplay impacts adaptations like Warburg effect, immune evasion, resistance. We discuss dual functionality both suppressor and, certain contexts, oncogenic factor, underscoring potential highly versatile target. Furthermore, SMURF2-HIF1α axis presents innovative approach destabilize hypoxia-dependent pathways, sensitizing tumors chemotherapy, radiotherapy, immune-based treatments. However, complexity necessitate thorough assessment off-target effects challenges specificity, which must be addressed optimize clinical application. concludes by proposing future directions research pathway, aiming refine targeted strategies exploit this address adaptive mechanisms aggressive tumors, ultimately advancing landscape precision oncology.
Язык: Английский
Процитировано
2
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(29), С. 16152 - 16162
Опубликована: Июль 11, 2024
Polyunsaturated fatty acids (PUFAs) are essential nutrients for the human body, playing crucial roles in reducing blood lipids, anti-inflammatory responses, and anticancer effect. Quinoa is a nutritionally sound food source, rich PUFAs. This study investigates role of quinoa polyunsaturated (QPAs) on quelling drug resistance colorectal cancer. The results reveal that QPA downregulates expression drug-resistant proteins P-gp, MRP1, BCRP, thereby enhancing sensitivity cancer cells to chemotherapy drug. also inhibits stemness by marker CD44. Consequently, it suppresses downstream protein SLC7A11 leads ferroptosis. Additionally, makes ferritin lower increases concentration free iron ions within cells, leading Overall, has dual-function reversing simultaneously inhibiting inducing provides new option sensitizers establishes theoretical foundation development utilization quinoa.
Язык: Английский
Процитировано
1
The FASEB Journal, Год журнала: 2024, Номер 38(17)
Опубликована: Сен. 1, 2024
Abstract Glutathione S‐transferase‐Pi 1 (GSTP1) is an isozyme that plays a key role in detoxification and antioxidative damage. It also confers resistance to tumor therapy. However, the specific of GSTP1 radiotherapy pancreatic cancer (PC) not known. In this study, we investigated how imparts radioresistance PC. The findings previous studies study revealed ionizing radiation (IR) induces ferroptosis cells, primarily by upregulating expression ACSL4. Our results showed after IR, prolonged survival cells inhibiting but did affect apoptosis. reduced cellular decreasing levels ACSL4 increasing GSH content. These changes increase xenograft tumors IR. indicate participates irradiation‐induced cell death prevents IR‐induced ferroptosis.
Язык: Английский
Процитировано
1
Journal of Ethnopharmacology, Год журнала: 2024, Номер unknown, С. 118886 - 118886
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
1
Phytomedicine, Год журнала: 2024, Номер 136, С. 156303 - 156303
Опубликована: Дек. 4, 2024
Abnormal antioxidant capacity in cancer cells is intimately linked to tumor aggressiveness. Modulating oxidative stress status and inhibiting ferroptosis represents a novel anticancer therapeutic strategy. STAM Binding Protein Like 1 (STAMBPL1), deubiquitinase, implicated various malignancies, yet its function potential for cholangiocarcinoma (CCA) remains unexplored.
Язык: Английский
Процитировано
1