Viruses,
Год журнала:
2024,
Номер
16(11), С. 1748 - 1748
Опубликована: Ноя. 7, 2024
Post-transcriptional
gene
regulation
mediated
by
microRNAs
(miRNAs)
relies
on
sequence
complementarity
between
the
miRNA
seed
site
and
target
transcript(s).
This
can
completely
inhibit
or
reduce
translation
into
protein.
We
hypothesized
that
viruses
employ
complementarity/similarity
with
host
miRNAs
to
increase
miRNA-mediated
of
expression
specifically
during
viral
infection(s).
In
this
study,
we
focus
Biochemical Society Transactions,
Год журнала:
2024,
Номер
52(3), С. 1131 - 1148
Опубликована: Июнь 17, 2024
The
RIG-I-like
receptors
(RLRs),
comprising
retinoic
acid-inducible
gene
I
(RIG-I),
melanoma
differentiation-associated
5
(MDA5),
and
laboratory
of
genetics
physiology
2
(LGP2),
are
pattern
recognition
belonging
to
the
DExD/H-box
RNA
helicase
family
proteins.
RLRs
detect
viral
RNAs
in
cytoplasm
respond
by
initiating
a
robust
antiviral
response
that
up-regulates
interferon
cytokine
production.
RIG-I
MDA5
complement
each
other
recognizing
different
features,
LGP2
regulates
their
activation.
RIG-I's
multilayered
proofreading
mechanisms
ensure
accurate
detection
while
averting
harmful
responses
host
RNAs.
C-terminal
domain
targets
5'-triphosphate
double-stranded
(dsRNA)
blunt
ends,
an
intrinsic
gating
mechanism
prevents
domains
from
non-specifically
engaging
with
ATPase
translocation
activity
adds
another
layer
selectivity
minimizing
lifetime
on
non-specific
RNAs,
preventing
off-target
versatility
function
also
amplifies
downstream
signaling
enhancing
(CARDs)
exposure
dsRNA
promoting
oligomerization.
In
this
review,
we
offer
in-depth
understanding
uses
facilitate
sensing
regulate
activation
immune
system.
Genomics,
Год журнала:
2024,
Номер
116(5), С. 110909 - 110909
Опубликована: Авг. 3, 2024
Transposable
elements
(TEs)
are
of
interest
as
immunomodulators
for
cancer
therapies.
TEs
can
fold
into
dsRNAs
that
trigger
the
interferon
response.
Here,
we
investigated
effect
different
HDAC
inhibitors
(HDACIs)
on
expression
in
leiomyosarcoma
cells.
Our
data
show
endogenous
retroviruses
(ERVs),
especially
ERV1
elements,
upregulated
after
treatment
with
HDAC1/2/3-specific
inhibitors.
Surprisingly,
response
was
not
activated.
We
observed
an
increase
A-to-I
editing
ERV1.
This
could
have
impact
stability
and
activation
also
found
H3K27ac
levels
increased
LTR12
subfamilies,
which
be
regulatory
controlling
proapoptotic
genes
such
TNFRSF10B.
In
summary,
provide
a
detailed
characterization
modulation
to
HDACIs
suggest
use
combination
ADAR
induce
cell
death
support
immunotherapy
cancer.
Viruses,
Год журнала:
2024,
Номер
16(11), С. 1748 - 1748
Опубликована: Ноя. 7, 2024
Post-transcriptional
gene
regulation
mediated
by
microRNAs
(miRNAs)
relies
on
sequence
complementarity
between
the
miRNA
seed
site
and
target
transcript(s).
This
can
completely
inhibit
or
reduce
translation
into
protein.
We
hypothesized
that
viruses
employ
complementarity/similarity
with
host
miRNAs
to
increase
miRNA-mediated
of
expression
specifically
during
viral
infection(s).
In
this
study,
we
focus
