Trends in Neurosciences, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Cell, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
18
Nano Letters, Год журнала: 2025, Номер unknown
Опубликована: Март 12, 2025
A lysosome-targeting chimera (LYTAC) offers a novel strategy for degrading extracellular proteins previously considered to be undruggable by hijacking the lysosomal degradation system. However, clinical use of LYTAC has been limited due potential uncontrolled and systemic toxicity. Based on our developed genetically encoded TfR-LYTAC, here, we introduce photothermal-inducible switch in engineered bacterium enable spatiotemporal expression TfR-LYTAC. We also precise photothermal systems control via cellphone manipulation avoid burns normal tissues, especially skin, caused intense laser light. The exhibited significant tumor-suppressing effects upon exposure phone-manipulated both subcutaneously transplanted melanoma colon tumor models with no skin damage mice. Our approach enables precision medicine provides generalizable platform developing light-driven LYTAC. study outpatient or home treatment is further step telemedicine.
Язык: Английский
Процитировано
1
Development, Год журнала: 2024, Номер 151(15)
Опубликована: Авг. 1, 2024
Changes in gene dosage can have tremendous evolutionary potential (e.g. whole-genome duplications), but without compensatory mechanisms, they also lead to dysregulation and pathologies. Sex chromosomes are a paradigmatic example of naturally occurring differences their compensation. In species with chromosome-based sex determination, individuals within the same population necessarily show 'natural' for chromosomes. this Review, we focus on mammalian X chromosome discuss recent new insights into dosage-compensation mechanisms that evolved along emergence chromosomes, namely X-inactivation X-upregulation. We evolution genetic loci molecular players involved, as well regulatory diversity potentially different requirements compensation across species.
Язык: Английский
Процитировано
5
Acta Biochimica et Biophysica Sinica, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
4
Communications Biology, Год журнала: 2025, Номер 8(1)
Опубликована: Март 18, 2025
Precise regulation of protein abundance is critical for cellular homeostasis, whose dysfunction may directly lead to human diseases. Optogenetics allows rapid and reversible control precisely defined processes, which has the potential be utilized dynamics at various scales. Here, we developed a novel optogenetics-based degradation system, namely Peptide-mediated OptoTrim-Away (POT) employs expressed small peptides effectively target endogenous unmodified proteins. By engineering light-induced oligomerization E3 ligase TRIM21, POT can rapidly trigger via proteasomal pathway. Our results showed that POT-PI3K POT-GPX4 modules, used iSH2 FUNDC1 domains specifically phosphoinositide 3-kinase (PI3K) glutathione peroxidase 4 (GPX4) respectively, were able potently induce these proteins by light. Both live-cell imaging biochemical experiments validated potency tools in downregulating cancer cell migration, proliferation, even promotion apoptosis. Therefore, believe offers an alternative practical solution manipulation levels, it could potentially employed dissect complex signaling pathways targeted therapies. controllable abundance, providing insights into intricate biological
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142667 - 142667
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Viruses, Год журнала: 2025, Номер 17(4), С. 562 - 562
Опубликована: Апрель 14, 2025
Tripartite motif (TRIM) proteins comprise an important class of E3 ubiquitin ligases that regulate numerous biological processes including protein expression, cellular signaling pathways, and innate immunity. This ubiquitous participation in fundamental aspects biology has made TRIM a focus study many fields illuminated the negative impact they exert when functioning improperly. Disruption function been linked to success various pathogens separately occurrence development several neurodegenerative diseases, making appealing candidate for novel therapeutic approaches. Here, we review current findings on demonstrate their analogous properties distinct viral infection central nervous system (CNS) disorders. We also examine recent advancements drug targeted degradation as potential strategies TRIM-mediated treatments discuss implications these technologies have future research directions.
Язык: Английский
Процитировано
0
Virology, Год журнала: 2024, Номер 600, С. 110283 - 110283
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
2
Trends in Neurosciences, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
0