Immune evasion: An imperative and consequence of MYC deregulation

Molecular Oncology, Год журнала: 2024, Номер unknown

Опубликована: Июль 2, 2024

MYC has been implicated in the pathogenesis of a wide range human tumors and described for many years as transcription factor that regulates genes with pleiotropic functions to promote tumorigenic growth. However, despite extensive efforts identify specific target alone could be responsible promoting tumorigenesis, field is yet reach consensus whether this crucial function MYC. Recent work shifts view on MYC's from being gene-specific an essential stress resilience factor. In highly proliferating cells, preserves cell integrity by DNA repair at core promoters, protecting stalled replication forks, and/or preventing transcription-replication conflicts. Furthermore, increasing body evidence demonstrates not only promotes tumorigenesis driving cell-autonomous growth, but also enables evade host's immune system. review, we summarize our current understanding how impairs antitumor immunity why evolutionarily hard-wired biology protein family. We show evasive are mutually dependent discuss ways proteins cancer therapy.

Язык: Английский

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Ginsenoside F2 inhibits MLCK to induce synthetic lethality in MYC-driven triple-negative breast cancer and pancreatic cancer

Phytochemistry Letters, Год журнала: 2025, Номер 67, С. 102949 - 102949

Опубликована: Март 27, 2025

Язык: Английский

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Integrative characterization of MYC RNA-binding function

Cell Genomics, Год журнала: 2025, Номер unknown, С. 100878 - 100878

Опубликована: Май 1, 2025

Emerging evidence suggests that MYC interacts with RNAs. Here, we performed an integrative characterization of as RNA-binding protein in six cell lines. We found binds to a myriad RNAs high affinity for guanosine-rich Global and specific depletion reduces chromatin occupancy. Mechanistically, two highly conserved sequences, amino acids 355-357 KRR 364-367 RQRR, within the basic region are necessary its RNA binding. Notably, alanine substitution abolishes MYC's ability both vitro vivo, without affecting bind E-box DNA part MYC:MAX dimer vitro. The loss function decreases binding vivo attenuates promote gene expression, cell-cycle progression, proliferation. Our study lays foundation future investigation into role MYC-mediated transcriptional activation oncogenic functions.

Язык: Английский

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MYCN in neuroblastoma: the kings' new clothes and drugs

EJC Paediatric Oncology, Год журнала: 2024, Номер 4, С. 100182 - 100182

Опубликована: Июль 27, 2024

Язык: Английский

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