bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Arboviruses are a group of arthropod-transmitted viruses that pose significant threat to public health. Identifying host factors inhibit arbovirus infection is critical for the development strategies prevent or treat these infections. Previously, we showed bacterial effector proteins can be used as molecular tools identify immunity in insect cells restrict replication (Embry et al., 2024). Bacteria secrete effectors into cell cytoplasm various innate immune defenses. Here, apply our screening system antiviral two mammalian hosts - bats and humans. By library 210 encoded by seven distinct pathogens, identified three (IpaH4, SopB, SidM) enhance both togaviruses rhabdoviruses bat human cells. We also discovered several virus- host-specific manner. further characterize mechanism which

Язык: Английский