PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance

Molecular Cell, Год журнала: 2024, Номер 84(23), С. 4645 - 4659.e9

Опубликована: Ноя. 14, 2024

Selenocysteine (Sec) metabolism is crucial for cellular function and ferroptosis prevention begins with the uptake of Sec carrier, selenoprotein P (SELENOP). Following uptake, released from SELENOP metabolized via selenocysteine lyase (SCLY), producing selenide, a substrate selenophosphate synthetase 2 (SEPHS2), which provides essential selenium donor, (H2SePO3-), biosynthesis Sec-tRNA. Here, we discovered an alternative pathway in mediated by peroxiredoxin 6 (PRDX6), independent SCLY. Mechanistically, demonstrate that PRDX6 can readily react selenide interact SEPHS2, potentially acting as delivery system. Moreover, functional significance this route human cancer cells, revealing notable association between elevated expression MYCN-amplified neuroblastoma subtype. Our study sheds light on previously unrecognized aspect its implications ferroptosis, offering further possibilities therapeutic exploitation.

Язык: Английский

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A comprehensive review on selenium and blood pressure: recent advances and research perspectives

Journal of Trace Elements in Medicine and Biology, Год журнала: 2025, Номер unknown, С. 127607 - 127607

Опубликована: Янв. 1, 2025

Язык: Английский

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Ferroptosis in immune chaos: Unraveling its impact on disease and therapeutic potential

Journal of Physiology and Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Язык: Английский

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Therapeutic prospects and potential mechanisms of Prdx6: as a novel target in musculoskeletal disorders

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 17, 2025

With the global population aging, musculoskeletal disorders (MSDs) have posed significant physical and psychological health challenges for patients as well a substantial economic burden on society. The advancements in conservative surgical interventions MSDs been remarkable recent years; however, current treatment modalities still fall short of meeting optimal requirements patients. Recently, peroxiredoxin 6 (Prdx6) has gained considerable attention from researchers due to its antioxidative, anti-inflammatory, anti-apoptotic properties. It found that Prdx6 is involved multiple system diseases, including MSDs; exact role lacking. This study aimed summarize structure, regulatory mechanism, potential function Prdx6. These findings may demonstrate novel target inhibiting advancement MSDs.

Язык: Английский

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N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4

Cell chemical biology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

N-acetyl-l-cysteine (NAC) is a medication and widely used antioxidant in cell death research. Despite its somewhat obscure mechanism of action, role inhibiting ferroptosis gaining increasing recognition. In this study, we demonstrate that NAC treatment rapidly replenishes the intracellular cysteine pool, reinforcing function as prodrug for cysteine. Interestingly, enantiomer, N-acetyl-d-cysteine (d-NAC), which cannot be converted into cysteine, also exhibits strong anti-ferroptotic effect. We further clarify NAC, d-NAC, all act direct reducing substrates GPX4, counteracting lipid peroxidation. Consequently, only GPX4-rather than system xc-, glutathione biosynthesis, or suppressor protein 1-is necessary d-NAC to prevent ferroptosis. Additionally, identify broad range GPX4 vitro, including β-mercaptoethanol. These findings provide new insights mechanisms underlying protective effects other potential GPX4-reducing against

Язык: Английский

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The selenoprotein P/ApoER2 axis facilitates selenium accumulation in selenoprotein P-accepting cells and confers prolonged resistance to ferroptosis

Redox Biology, Год журнала: 2025, Номер 83, С. 103664 - 103664

Опубликована: Май 5, 2025

Язык: Английский

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Mechanism of ferroptosis in heart failure: The role of the RAGE/TLR4-JNK1/2 pathway in cardiomyocyte ferroptosis and intervention strategies

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102770 - 102770

Опубликована: Май 1, 2025

Язык: Английский

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Lipid Peroxidation, Ferroptosis and Antioxidants

Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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Oxygen needs sulfur, sulfur needs oxygen: a relationship of interdependence

The EMBO Journal, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

Abstract Oxygen and sulfur, both members of the chalcogen group (group 16 elements), play fundamental roles in life. Ancient organisms primarily utilized sulfur for energy metabolism, while rise atmospheric oxygen facilitated evolution aerobic organisms, enabling highly efficient production. Nevertheless, all modern aerobes anaerobes, must protect themselves from toxicity. Interestingly, still rely on survival. This dependence has been illuminated by recent discovery supersulfides, a novel class biomolecules, made possible through advancements technology analytical methods. These breakthroughs are reshaping our understanding biological processes emphasizing intricate interplay between regulating essential redox reactions. review summarizes latest insights into oxygen, their interdependence key processes, contributions to adaptive responses environmental stressors. By exploring these interactions, we aim provide comprehensive perspective how elements drive survival strategies across diverse life forms, highlighting indispensable human health sustenance

Язык: Английский

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The metabolic code of ferroptosis: nutritional regulators of cell death

Trends in Biochemical Sciences, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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