Passage of the HIV capsid cracks the nuclear pore

Cell, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Feeling the force from within – new tools and insights into nuclear mechanotransduction

Journal of Cell Science, Год журнала: 2025, Номер 138(5)

Опубликована: Март 1, 2025

The ability of cells to sense and respond mechanical signals is essential for many biological processes that form the basis cell identity, tissue development maintenance. This process, known as mechanotransduction, involves crucial feedback between force biochemical signals, including epigenomic modifications establish transcriptional programs. These programs, in turn, reinforce properties its withstand perturbation. nucleus has long been hypothesized play a key role mechanotransduction due direct exposure forces transmitted through cytoskeleton, receiving cytoplasmic central function gene regulation. However, parsing out specific contributions from those surface cytoplasm remains substantial challenge. In this Review, we examine latest evidence on how regulates both via nuclear envelope (NE) epigenetic machinery elements within interior. We also explore establishing memory, characterized by mechanical, transcriptomic state persists after stimuli cease. Finally, discuss current challenges field present technological advances are poised overcome them.

Язык: Английский

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Dynamic structure and function of nuclear pore protein complex: Potential roles of lipid and lamins regulated nuclear membrane curvature

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 144104 - 144104

Опубликована: Май 1, 2025

Язык: Английский

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Opening the gate: Complexity and modularity of the nuclear pore scaffold and basket

Current Opinion in Cell Biology, Год журнала: 2025, Номер 92, С. 102461 - 102461

Опубликована: Янв. 17, 2025

Язык: Английский

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