Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
unknown, С. 1 - 25
Опубликована: Сен. 4, 2024
Silk
proteins,
viz.,
sericin,
fibroin
and
their
modified
forms
etc.,
have
been
thoroughly
researched
as
natural
biopolymers
for
the
development
of
varied
nanomaterials
exhibiting
diverse
biomedical
applications.
The
silk
proteins
are
extracted
from
cocoons
by
degumming
treatment
with
soaps,
followed
dissolution
dialysis
against
water.
These
exhibit
distinct
mechanical
physicochemical
characteristics
including
biocompatibility,
controlled
biodegradability,
self-assembling
traits,
chemical
modifiability,
adaptability,
thus
making
it
an
ideal
drug
delivery
vehicle.
In
this
regard,
protein-derived
systems
reported
efficient
carrier
to
encapsulate
stabilize
wide
variety
pharmacological
molecules,
enzymes,
vaccines,
even
DNA,
allowing
them
remain
active
a
longer
period
time.
Further,
different
carriers
employing
these
multitude
applications
include
hydrogels,
sponges,
fibres,
scaffolds
particulate
systems.
Additionally,
modification
has
further
opened
avenues
other
improved
traits
hence
enormous
potential
in
bioenhanced
current
article
provides
holistic
information
characteristics,
types
protein-based
carriers,
fabrication
techniques,
while
emphasizing
biomedicine
delivery.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3188 - 3188
Опубликована: Фев. 6, 2023
Biopolymeric
nanoparticles
are
gaining
importance
as
nanocarriers
for
various
biomedical
applications,
enabling
long-term
and
controlled
release
at
the
target
site.
Since
they
promising
delivery
systems
therapeutic
agents
offer
advantageous
properties
such
biodegradability,
biocompatibility,
non-toxicity,
stability
compared
to
toxic
metal
nanoparticles,
we
decided
provide
an
overview
on
this
topic.
Therefore,
review
focuses
use
of
biopolymeric
animal,
plant,
algal,
fungal,
bacterial
origin
a
sustainable
material
potential
drug
systems.
A
particular
focus
is
encapsulation
many
different
categorized
bioactive
compounds,
drugs,
antibiotics,
other
antimicrobial
agents,
extracts,
essential
oils
into
protein-
polysaccharide-based
nanocarriers.
These
show
benefits
human
health,
especially
successful
anticancer
activity.
The
article,
divided
protein-based
further
according
biopolymer,
enables
reader
select
appropriate
more
easily
incorporation
desired
component.
latest
research
results
from
last
five
years
in
field
production
loaded
with
healthcare
applications
included
review.
Carbohydrate Polymer Technologies and Applications,
Год журнала:
2023,
Номер
6, С. 100352 - 100352
Опубликована: Авг. 18, 2023
In
this
study,
the
synthesis
of
a
new
chitosan-based
Schiff
base
with
surface
modification
using
chloroethanoic
acid
was
reported.
The
physicochemical
attributes
modified
chitosan
were
studied.
characterized
X-ray
diffraction
(XRD)
technique;
Fourier
transform
infrared
(FTIR)
and
UV-visible
spectroscopies;
thermogravimetric
analysis;
differential
scanning
calorimetry
(DSC).
Bruner-Emmett-Teller
(BET)
analysis
performed
to
determine
area
synthesized
compound
electron
microscope
(SEM)
characterize
its
morphology.
adsorption
efficacy
Bismarck
Brown
R
evaluated
through
multilayer
formation,
whereas
Eosin
Y
adsorbed
onto
homogenous
formation
monolayer.
Additionally,
base's
for
BBR
EY
dye
calculated
be
327
mg/g
386
mg/g,
respectively.
effectively
inhibited
both
gram
positive
negative
bacteria,
thus,
exhibiting
antibacterial
properties.
results
showed
that
could
used
remove
dyes
from
wastewater.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 1890 - 1890
Опубликована: Фев. 22, 2025
Sericin,
a
natural
macromolecular
protein
and
the
main
component
of
silkworm
cocoons,
exhibits
biocompatibility,
excellent
mechanical
properties,
biodegradability.
Previous
research
has
confirmed
that
sericin
possesses
anticancer
properties.
Gastric
cancer
(GC)
poses
serious
hazard
to
human
health,
with
low
rate
early
diagnosis
poor
prognosis.
Investigating
safety
effectiveness
drugs
for
their
used
in
treatment
is
imperative.
In
this
study,
we
Antherea
pernyi
(APS)
inhibited
proliferation,
migration,
clonal
formation
GC
cells
caused
apoptosis
by
regulating
expression
Bcl2
Bax.
Moreover,
our
data
show
APS
did
not
exhibit
significant
toxicity
normal
gastric
mucosal
mice.
Furthermore,
results
suppressed
proliferation
cisplatin-resistant
promoted
cellular
apoptosis;
however,
it
had
no
synergistic
effects
cisplatin.
All
indicated
antitumor
activity
against
prospective
medicinal
agent
clinical
GC,
minimal
adverse
side
effects.
This
can
provide
theoretical
basis
field
tumor
treatment,
especially
application
polypeptide
drugs.
