Exploring the potential of deep eutectic solvents in pharmaceuticals: Challenges and opportunities

Journal of Molecular Liquids, Год журнала: 2023, Номер 390, С. 123171 - 123171

Опубликована: Сен. 26, 2023

Язык: Английский

---

Deep Eutectic Solvents Enhancing Drug Solubility and Its Delivery

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(17), С. 14807 - 14819

Опубликована: Авг. 26, 2024

Deep eutectic solvents (DES) are environmentally friendly with the potential to dissolve bioactive compounds without affecting their characteristics. DES has special qualities that can be customized meet unique characteristics of a biomolecule/active pharmaceutical ingredient (API) in accordance various therapeutic needs, providing reliable approach opening door for creation cutting-edge drug formulations by resolving solubility issues pharmaceutics. This study outlines newly developing approaches solve problem inefficient API extraction due poor solubility. These emerging strategies also have capacity alter chemical and physical stability API, which triggers drug's shelf life possible health benefits. It is anticipated highlighted methods processes will developed capitalize on improve delivery sector.

Язык: Английский

---

Regulating Zn2+ solvation structure in eutectic electrolytes for rechargeable zinc batteries

Matter, Год журнала: 2025, Номер 8(2), С. 101917 - 101917

Опубликована: Фев. 1, 2025

Язык: Английский

---

On the properties of water in betaine – based Deep Eutectic Solvents

Journal of Molecular Liquids, Год журнала: 2024, Номер 406, С. 124871 - 124871

Опубликована: Май 11, 2024

Deep eutectic solvents have gained attention as environmentally friendly alternatives in various technological applications. Likewise, it is known the relevant effect of water on physicochemical properties Eutectics, especially for hydrophilic ones. In this study, Betaine – based type III Eutectic (with ethylene glycol, fructose, malic acid or citric Hydrogen Bond Donors) are considered and structuring solutions (content lower than 20 %) were investigated considering volumetric properties, optical (refraction index), dynamic (viscosity, thermal conductivity, electrical conductivity) well characteristics liquid phase nature such polarizability molecular packing. Viscosity measurements demonstrated a wide variation viscosities, with content playing significant role, thus probing how largely affect Eutectics. Additionally, high led to improved particularly mixtures containing Donors. The decreased increasing content, packing calculations indicated that most voluminous molecules occupied interstitial voids. Our findings contribute understanding Eutectics solution, aiding their optimization sustainable

Язык: Английский

---

Novel therapeutic deep eutectic system for the enhancement of ketoconazole antifungal activity and transdermal permeability

Journal of Molecular Liquids, Год журнала: 2024, Номер 413, С. 125975 - 125975

Опубликована: Сен. 12, 2024

Язык: Английский

---

Green extraction and IC analysis of trace impurities in TATB through deep eutectic solvents

Journal of Chromatography A, Год журнала: 2025, Номер 1743, С. 465680 - 465680

Опубликована: Янв. 13, 2025

Язык: Английский

---

Double-Brønsted acidic deep eutectic solvents and their applications as solvents and catalysts in chemical transformations

Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127110 - 127110

Опубликована: Фев. 1, 2025

Язык: Английский

---

The glycerol/water mixture is an effective deep eutectic solvent for the extraction of bioactive components from food waste matrices

Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127416 - 127416

Опубликована: Март 1, 2025

Язык: Английский

---

Thermodynamic study on CO2 separation by diamine functionalized aqueous deep eutectic solvents

Separation and Purification Technology, Год журнала: 2025, Номер unknown, С. 132877 - 132877

Опубликована: Апрель 1, 2025

Язык: Английский

---

Natural Eutectic Mixtures of Sodium Salt and Fatty Acids as Electrolytes for Supercapacitors

ACS Sustainable Chemistry & Engineering, Год журнала: 2024, Номер 12(4), С. 1365 - 1377

Опубликована: Янв. 18, 2024

High-power energy storage devices, and supercapacitors (SCs) in particular, are critical for the progress of sector as they gather distinctive characteristics, namely, long cyclability high-power density. However, SC still faces some challenges, very low density when compared to batteries need operate organic solvents attain larger potential windows. Therefore, advances necessary reach higher more environmentally friendly electrolytes. This study focuses on testing mixtures water with hydrophobic eutectic systems (ESs), which components compatible, electrolytes SCs. Four different ESs sodium hexanoate carboxyl acids (hexanoic acid, octanoic nonanoic decanoic acid) were studied. The physical characterization these was studied through measurement exploration several properties, sol–gel diagrams, conductivity, viscosity, density, ionicity. electrochemical performance tested double-layer capacitor cells microporous activated carbon electrodes cyclic voltage diffraction galvanostatic charge–discharge. Overall, it observed that hydrophobicity allows conductive gels form simply by adding water. conductivity fluidity increased content. Additionally, specific capacitance decreases acid chain increases, while voltammograms, resistive features vanish content increases. From this study, ES hexanoic 60% molar composition [NaC6:C6(0.6)] showed highest 22.3 mS/cm at 293.15 K, electrode capacitance, 71.6 F/g 0.2 A/g, a weight 60%.

Язык: Английский

---