Fabrication of protective epoxy coatings based on zinc tannate and diethylentriamine: Machine learning-driven insights for long-term performance predictions

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 137096 - 137096

Опубликована: Май 1, 2025

Язык: Английский

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Black ginseng under forest as a natural antidepressant: insights into its active components and mechanisms

Frontiers in Chemistry, Год журнала: 2025, Номер 13

Опубликована: Май 30, 2025

Depression is a psychological disorder with significant global impact. It widely hypothesized that this associated neuroinflammation, which disrupts neural homeostasis through various pathways. This study aims to investigate the effective compounds and mechanisms of Black Ginseng under forest (BG) in combating neuroinflammation. Utilizing methods such as UPLC-QE Orbitrap-MS, network pharmacology, molecular docking, cell biology, efficacy BG was demonstrated, its active components were identified. Cell viability apoptosis assessed using Trans well migration assays flow cytometry. The mRNA expression target genes confirmed real-time quantitative PCR (RT-qPCR), elucidating anti-neuroinflammatory mechanism. results indicated exhibited more pronounced effect on ameliorating neuroinflammatory conditions compared (FG). main found research development, including Ginsenoside F1, Rk1, Rg3, etc. Among these, F1 emerged most potent component for treating evidenced by reduced apoptosis. demonstrates can modulate PI3K-Akt signaling pathway, leading reduction levels AKT1, MAPK1, PIK3CA, EGFR, other mRNAs. These findings suggest promising natural antidepressant, providing both theoretical experimental foundations development new antidepressants based components.

Язык: Английский

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Solid phase extraction of Aflatoxin M1 in milk samples by graphene oxide-poly-L-lysine nanocomposite followed by HPLC

International Journal of Environmental & Analytical Chemistry, Год журнала: 2023, Номер unknown, С. 1 - 14

Опубликована: Окт. 1, 2023

ABSTRACTAn efficient, novel and green Graphene Oxide-Poly-L-Lysine (GO-PLL) adsorbent was successfully synthesised used for solid-phase extraction of aflatoxin M1 (AFM1) in liquid milk samples followed by high performance chromatography (HPLC) equipped with fluorescence detector (FLD). The characterised Fourier Transform Infrared Spectrophotometry (FT-IR), Field Emission Scanning Electron Microscopy (FESEM), Energy-dispersive X-ray spectroscopy (EDX) X-Ray diffraction (XRD) analysis. Different parameters affecting the recovery percentage AFM1 including pH sample solution, amounts adsorbent, contact time desorbent solution (types volume) were completely investigated optimised. It found that, an enrichment factor 15.2, calibration curve is linear range 0.05–4.00 ng ml−1 limit detection (LOD) quantification (LOQ) values 0.019 0.063 mL−1, respectively. relative standard deviations (RSDs) ranged from 4.5% to 5.7% 4.2% 6.7% intra-day inter-day variations, Finally, proposed method applied determination trace levels different samples.KEYWORDS: Aflatoxin M1Graphene adsorbentHPLCmilk AcknowledgmentsThe authors wish thank University Neyshabur financial support this project (grant number: 14703).Disclosure statementNo potential conflict interest reported author(s).Additional informationFundingThis work supported Medical Sciences [grant number:14703].

Язык: Английский

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Hydrothermally synthesis of a green SnS-Carbon microplate adsorbent for the removal of mercury ion from water samples

Diamond and Related Materials, Год журнала: 2024, Номер unknown, С. 111678 - 111678

Опубликована: Окт. 1, 2024

Язык: Английский

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