Abstract
Assemblies
of
magnesium
and
bismuth
oxides
(Mg−Bi−O)
were
synthesized
with
(MBO
:
Fe)
without
iron
(MBO)
by
using
a
hydrothermal
method.
Such
assemblies
utilized
to
promote
the
germination
growth
pinto
bean
seedlings.
The
MBO
Fe
had
rambutan‐like
morphology,
which
is
composed
nanohairs/flagella.
loaded
fomesafen
herbicide
release
kinetics
such
was
explained
Korsmeyer‐Peppas
model
non‐Fickian
transport
mechanism.
cumulative
at
pH
7.5
reached
percentages
4.38
%,
71.02
75.04
100
%
for
MBO,
MBO‐1
Fe,
MBO‐3
MBO‐5
respectively.
Also,
plants.
samples
83.33,
100,
91.67
are
higher
than
that
control
plants
grown
(66.67
%).
longest
root/shoot
lengths
(20.62/48
cm)
obtained
plant
assembly.
In
contrast,
lower
(14.7/30.66
Thus,
improved
physical
characteristics
plants,
interest
sustainable
agriculture.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 786 - 786
Опубликована: Янв. 8, 2024
Studies
on
bionanocomposite
drug
carriers
are
a
key
area
in
the
field
of
active
substance
delivery,
introducing
innovative
approaches
to
improve
therapy.
Such
play
crucial
role
enhancing
bioavailability
substances,
affecting
therapy
efficiency
and
precision.
The
targeted
delivery
drugs
sites
action
minimization
toxicity
body
is
becoming
possible
through
use
these
advanced
carriers.
Recent
research
has
focused
structures
based
biopolymers,
including
lipids,
polysaccharides,
proteins.
This
review
paper
description
lipid-containing
nanocomposite
(including
liposomes,
lipid
emulsions,
nanoparticles,
solid
nanostructured
carriers),
polysaccharide-containing
alginate
cellulose),
protein-containing
(e.g.,
gelatin
albumin).
It
was
demonstrated
many
investigations
that
such
show
ability
load
therapeutic
substances
efficiently
precisely
control
release.
They
also
desirable
biocompatibility,
which
promising
sign
for
their
potential
application
development
indicates
novel
approach
improving
processes,
contribute
significant
advances
pharmacology,
efficacy
while
minimizing
side
effects.
Inorganic Chemistry Communications,
Год журнала:
2024,
Номер
163, С. 112338 - 112338
Опубликована: Март 23, 2024
Cancer
has
consistently
been
a
significant
global
concern
as
the
leading
second
cause
of
death.
Improving
performance
chemical
methods
using
drug
delivery
system
is
an
alternative
approach
to
cancer
treatment.
In
this
study,
anti-cancer
drug,
quercetin
(QC),
was
investigated
by
placing
it
in
pH-sensitive
hydrogel
nanocomposite
made
polyacrylic
acid
(PAA),
agarose,
and
Fe3O4@SiO2
particles.
Then,
release
control
improved
double
emulsion
method.
Spherical
nanoparticles
with
smooth
surface
morphology
were
observed
images
obtained
through
field-emission
scanning
electron
microscopy
(FESEM),
their
average
size
determined
be
193
nm
dynamic
light
scattering
(DLS)
method,
they
exhibited
zeta
potential
38
mV.
Fourier
transform
infrared
spectroscopy
(FTIR)
X-ray
diffraction
(XRD)
analyses
provided
evidence
interactions
bonds
structure.
The
magnetic
properties
nanocarrier
studied
vibrating-sample
magnetometry
(VSM).
amount
loaded
PAA-Agarose/Fe3O4@SiO2
increased
86
%,
while
encapsulation
efficiency
48
%.
Drug
kinetics
at
physiological
(7.4)
acidic
(5.4)
pH
best
fitted
Korsmeyer-Peppas
model,
indicating
non-Fickian
diffusion
mechanism.
U-87
MG
glioma
cell
line
evaluated
for
toxicity
cytotoxicity
assay
(MTT)
flow
cytometry.
A
higher
percentage
apoptosis
found
PAA-Agarose/Fe3O4@SiO2-QC
compared
free
QC
system.
findings
corroborate
that
developed
herein
highly
effective
pH-responsive
treatment
applications.
Hybrid Advances,
Год журнала:
2024,
Номер
5, С. 100139 - 100139
Опубликована: Янв. 1, 2024
Nanotechnology,
rather
than
traditional
medicinal
procedures
like
chemotherapy,
now
helps
to
reduce
adverse
effects.
There
is
a
great
demand
for
biocompatible
nanocarrier
with
long
half-life,
high
bioavailability,
and
capable
of
imaging
cells
targeting
them
selectively.
A
procedure
known
as
water-in-oil-in-water
(W/O/W)
emulsification
was
employed
produce
hybrid
nanohydrogels
containing
agarose,
polyvinyl
alcohol,
halloysite
nanotubes,
5-fluorouracil
(AGA-PVA-HNT@5-Fu)
which
can
be
highly
effective
decreasing
the
particle
size
improving
their
uniformity.
These
hydrogels
were
produced
specifically
target
administer
5-Fu
anti-cancer
drug
treatment
breast
cancer.
Following
evaluation
physicochemical
characteristics,
both
substantial
loading
efficient
trapping
accomplished.
The
displayed
zeta
potential
−38.4
mV
indicative
good
stability
due
usage
span
80.
Based
on
release
profile
conducted
in
vitro,
it
observed
that
AGA-PVA-HNT@5-Fu
released
medication
regulated
way.
By
using
MTT
flow
cytometry
analysis,
found
could
effectively
eliminate
tumor
cells,
while
blank
nanoparticles
proved
biocompatible.
results
indicate
based
utilized
treating
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 15, 2025
Cancer
immunotherapy
aims
to
harness
the
body's
own
immune
system
for
effective
and
long-lasting
elimination
of
malignant
neoplastic
tissues.
Owing
advance
in
understanding
cancer
pathology
immunology,
many
novel
strategies
enhancing
immunological
responses
against
various
cancers
have
been
successfully
developed,
some
translated
into
excellent
clinical
outcomes.
As
one
promising
strategy
next
generation
immunotherapies,
activating
multi-cellular
network
(MCN)
within
tumor
microenvironment
(TME)
deploy
multiple
mechanisms
action
(MOAs)
has
attracted
significant
attention.
To
achieve
this
effectively
safely,
delivering
or
pleiotropic
therapeutic
cargoes
targeted
sites
cancerous
tissues,
cells,
intracellular
organelles
is
critical,
which
numerous
nanocarriers
developed
leveraged.
In
review,
we
first
introduce
payloads
categorized
according
their
predicted
functions
physicochemical
structures
forms.
Then,
nanocarriers,
along
with
unique
characteristics,
properties,
advantages,
limitations,
are
introduced
notable
recent
applications
immunotherapy.
Following
discussions
on
targeting
strategies,
a
summary
each
nanocarrier
matching
suitable
provided
comprehensive
background
information
designing
regimens.
Therapeutic Delivery,
Год журнала:
2024,
Номер
15(4), С. 279 - 303
Опубликована: Фев. 20, 2024
Breast
cancer
(BC)
is
a
heterogeneous
disease
with
various
morphological
features,
clinicopathological
conditions
and
responses
to
different
therapeutic
options,
which
responsible
for
high
mortality
morbidity
in
women.
The
heterogeneity
of
BC
necessitates
new
strategies
diagnosis
treatment,
possible
only
by
cautious
harmonization
the
advanced
nanomaterials.
Recent
developments
vesicular
nanocarrier
therapy
indicate
paradigm
shift
breast
treatment
providing
an
integrated
approach
address
current
issues.
This
review
provides
detailed
classification
nanovesicles
special
emphasis
on
recent
advances,
challenges
translating
nanomaterials
future
potentials.
