Synthesis of Functional Pectin‐Based Hydrogels via Thiol‐Maleimide Click Reaction for Enhanced Drug Encapsulation and Release

Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

ABSTRACT This work describes the synthesis and characterization of a novel hydrogel system based on pectin (PT) functionalized with thiol maleimide groups cross‐linked by thiol‐maleimide click chemistry. Thiolated PT (PT‐SH) maleimide‐modified (PT‐Ma) precursors were synthesized carbodiimide‐mediated amidation confirmed elemental analysis, FTIR, 1H NMR spectroscopy. The resulting exhibited gelation efficiency over 80%, swelling degrees ranging from 44% to 80% depending cross‐linking density, pH‐sensitive behavior maximum at pH 8. demonstrated high mechanical stability, compressive strengths 20.8–33.2 kPa, increasing density. As model drug, ibuprofen was encapsulated efficiencies up 337 mg/g released in controlled fashion. In vitro release studies showed slower acidic environments, which ranged 22% 53% within 6–10 h, faster slightly alkaline environment, consistent profile hydrogel. Such properties underline hydrogel's potential for sustained drug delivery. Pectin hydrogels, upon cross‐linking, are hereby presented be strong platform biomedical applications properties, behavior, performance

Язык: Английский

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Synthesis of gold nanoparticles using deep eutectic solvents and their incorporation into polyvinyl alcohol–based eutectogels: structural, chemical, and functional analysis

Colloid & Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Study on the structural characterization of Premna microphylla Turcz polysaccharides and their improvement effect on the properties of chitosan composite gel

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143015 - 143015

Опубликована: Апрель 1, 2025

Язык: Английский

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Nanocapsule Formation of Ciprofloxacin-Loaded Zirconia Nanoparticles Coated with Chitosan for Antibacterial, Antibiofilm, Anti-Inflammatory, and Catalytic Applications

Journal of Cluster Science, Год журнала: 2025, Номер 36(4)

Опубликована: Июнь 2, 2025

Язык: Английский

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A novel efficient liquefaction process for corn starch through ternary deep eutectic solvent: Products characterization and liquefaction mechanism

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 289, С. 138929 - 138929

Опубликована: Дек. 18, 2024

Язык: Английский

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