In Silico Detection and Conveyance Feasibility of Antifungal Prodrug Flucytosine on the Surface of Pristine and Germanium‐Doped SiC Nanosheet DOI

Anjaly B. Krishna,

Arjun Suvilal,

Rakhesh Vamadevan

и другие.

Small Methods, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

Abstract The work describes a novel sensing and transportation feasibility of the well‐established antifungal drug Flucytosine (5‐FC) using 2D Silicon carbide (SiC) Germanium‐doped (Ge@SiC) nanosheet via PBE level Density functional theory. computational study revealed that molecules adhere to SiC Ge@SiC sheets, maintaining their structural properties through physisorption on chemisorption Ge@SiC. charge transfer process associated with adsorption is observed by Lowdin analysis both sheets are identified as feasible oxidation‐based nanosensor for drug. results electronic property calculation reduction in bandgap 48.2% 44.8% respectively drug, highlighting be used bandgap‐based device. Sensing response at room temperature human body suggested that, sheet has an excellent selectivity drug's desorption efficiency from carrier analyzed recovery time different temperatures frequencies, suggesting better candidate. Together, highlights potential ability contrast existing 0‐D nanostructures.

Язык: Английский

Effect of the ratio of carboxyl group to ethylene oxide on performance of acrylic acid based copolymer scale inhibitors DOI Creative Commons
Hailin Hu,

Jia-Lin Wang,

Jiaojiao Wang

и другие.

Desalination and Water Treatment, Год журнала: 2025, Номер unknown, С. 101035 - 101035

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

DFT analysis of dimethyl fumarate interactions with B12N12 and B24 nanoclusters for enhanced anticancer drug delivery DOI
Ali Zamani,

Fadhel F. Sead,

Irwanjot Kaur

и другие.

Computational and Theoretical Chemistry, Год журнала: 2025, Номер unknown, С. 115168 - 115168

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

DFT study of (6,0) boron nitride nanotube as a drug delivery system for 5-fluorouracil and hydroxyurea DOI

Ali Bizaval,

Zahra Karami Horastani, S. Javad Hashemifar

и другие.

The European Physical Journal Plus, Год журнала: 2025, Номер 140(5)

Опубликована: Май 4, 2025

Язык: Английский

Процитировано

0

Computational investigation of sulfasalazine adsorption on BN and CSi nanocages: Insights into drug-nanocarrier interactions in aqueous environment DOI
Ashraf Sadat Ghasemi, S. Morteza Mousavi–Khoshdel,

Mohammad Amir Saadatinasab

и другие.

Computational and Theoretical Chemistry, Год журнала: 2025, Номер unknown, С. 115279 - 115279

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Encapsulation of anticancer drugs into carbon nanotubes: Heuristic algorithm approach and mathematical model DOI Creative Commons
Kanes Sumetpipat, Duangkamon Baowan

PLoS ONE, Год журнала: 2025, Номер 20(5), С. e0321403 - e0321403

Опубликована: Май 20, 2025

This research combines mathematical derivation and optimization techniques to investigate the non-covalent encapsulation of chemotherapy drugs (fluorouracil, proflavine, methylene blue, doxorubicin) within carbon nanotubes, aiming improve targeted drug delivery in cancer therapy. We derive analytical expression for interaction energy between an atom infinite cylinder, utilize U-NSGA-III algorithm optimize system’s by varying molecular positions tube radius. Optimal radii single- dual-drug encapsulations are determined. Fixing radius at 10 Å number molecules, we observe that shortest distance from drug’s center mass wall is independent encapsulated depending only on type. Moreover, equilibrium configurations exhibit two primary patterns, clustering near or dispersion around circumference, suggesting potential control mechanisms release kinetics. hybrid approach, integrating computational methods, significantly reduces cost, providing a foundation studying drug-nanocarrier interactions, ultimately accelerating development more effective treatments.

Язык: Английский

Процитировано

0

Effect of Fe(II) and Fe(III) doping levels on the structural and binding mechanism of graphene oxide chitosan: Spectral analysis and density function theory calculation DOI
Yun-Quan Liu,

Huinan Mo,

Huimei Shan

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 144635 - 144635

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

In Silico Detection and Conveyance Feasibility of Antifungal Prodrug Flucytosine on the Surface of Pristine and Germanium‐Doped SiC Nanosheet DOI

Anjaly B. Krishna,

Arjun Suvilal,

Rakhesh Vamadevan

и другие.

Small Methods, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

Abstract The work describes a novel sensing and transportation feasibility of the well‐established antifungal drug Flucytosine (5‐FC) using 2D Silicon carbide (SiC) Germanium‐doped (Ge@SiC) nanosheet via PBE level Density functional theory. computational study revealed that molecules adhere to SiC Ge@SiC sheets, maintaining their structural properties through physisorption on chemisorption Ge@SiC. charge transfer process associated with adsorption is observed by Lowdin analysis both sheets are identified as feasible oxidation‐based nanosensor for drug. results electronic property calculation reduction in bandgap 48.2% 44.8% respectively drug, highlighting be used bandgap‐based device. Sensing response at room temperature human body suggested that, sheet has an excellent selectivity drug's desorption efficiency from carrier analyzed recovery time different temperatures frequencies, suggesting better candidate. Together, highlights potential ability contrast existing 0‐D nanostructures.

Язык: Английский

Процитировано

0