FerrDb V2: update of the manually curated database of ferroptosis regulators and ferroptosis-disease associations

Nucleic Acids Research, Год журнала: 2022, Номер 51(D1), С. D571 - D582

Опубликована: Окт. 28, 2022

Abstract Ferroptosis is a mode of regulated cell death characterized by iron-dependent accumulation lipid peroxidation. It closely linked to the pathophysiological processes in many diseases. Since our publication first ferroptosis database 2020 (FerrDb V1), new findings have been published. To keep up with rapid progress research and provide timely high-quality data, here we present successor, FerrDb V2. contains 1001 regulators 143 ferroptosis-disease associations manually curated from 3288 articles. Specifically, there are 621 gene regulators, which 264 drivers, 238 suppressors, 9 markers, 110 unclassified genes; 380 substance 201 inducers 179 inhibitors. Compared V1, articles increase >300%, 175%, 50.5%. Circular RNA pseudogene novel V2, percentage non-coding increases 7.3% 13.6%. External gene-related data were integrated, enabling thought-provoking gene-oriented analysis In conclusion, V2 will help acquire deeper insights into ferroptosis. freely accessible at http://www.zhounan.org/ferrdb/.

Язык: Английский

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Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июль 22, 2022

Quercetin, a naturally non-toxic flavonoid within the safe dose range with antioxidant, anti-apoptotic and anti-inflammatory properties, plays an important role in treatment of aging-related diseases. Sirtuin 1 (SIRT1), member NAD+-dependent deacetylase enzyme family, is extensively explored as potential therapeutic target for attenuating aging-induced disorders. SIRT1 possess beneficial effects against diseases such Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), Depression, Osteoporosis, Myocardial ischemia (M/I) reperfusion (MI/R), Atherosclerosis (AS), Diabetes. Previous studies have reported that aging increases tissue susceptibility, whereas, regulates cellular senescence multiple processes, including SIRT1/Keap1/Nrf2/HO-1 SIRTI/PI3K/Akt/GSK-3β mediated oxidative stress, SIRT1/NF-κB SIRT1/NLRP3 regulated inflammatory response, SIRT1/PGC1α/eIF2α/ATF4/CHOP SIRT1/PKD1/CREB controlled phosphorylation, SIRT1-PINK1-Parkin mitochondrial damage, SIRT1/FoxO autophagy, SIRT1/FoxG1/CREB/BDNF/Trkβ-catenin neuroprotective effects. In this review, we summarized improvement attenuation effect quercetin on relationship between relevant signaling pathways by SIRT1. Moreover, functional regulation markers function, autophagy apoptosis through was discussed. Finally, prospects extracellular vesicles (EVs) loading delivery, SIRT1-mediated EVs signal carriers treating diseases, well discussed ferroptosis alleviation to protect via activating Generally, may serve promising inhibiting reducing responses, restoring dysfunction.

Язык: Английский

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Signaling pathways in Parkinson’s disease: molecular mechanisms and therapeutic interventions

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Фев. 21, 2023

Abstract Parkinson’s disease (PD) is the second most common neurodegenerative worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be related to environmental genetic factors, exposure toxins gene mutations beginning brain lesions. identified mechanisms include α-synuclein aggregation, oxidative stress, ferroptosis, mitochondrial dysfunction, neuroinflammation, gut dysbiosis. interactions among these molecular complicate pose great challenges drug development. At same time, diagnosis detection are also one obstacles due long latency complex mechanism. Most conventional therapeutic interventions for possess limited effects have serious side effects, heightening need develop novel treatments this disease. In review, we systematically summarized pathogenesis, especially PD, classical research models, clinical diagnostic criteria, reported therapy strategies, as well newly candidates in trials. We shed light on components derived from medicinal plants that their treatment, with expectation provide summary outlook developing next generation drugs preparations therapy.

Язык: Английский

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Hyper-sausage coverage function neuron model and learning algorithm for image classification

Pattern Recognition, Год журнала: 2022, Номер 136, С. 109216 - 109216

Опубликована: Дек. 8, 2022

Recently, deep neural networks (DNNs) promote mainly by network architectures and loss functions; however, the development of neuron models has been quite limited. In this study, inspired mechanism human cognition, a hyper-sausage coverage function (HSCF) model possessing high flexible plasticity. Then, novel cross-entropy volume-coverage (CE_VC) is defined, which compresses volume to hilt, helps alleviate confusion among different classes, thus ensuring intra-class compactness samples. Finally, divisive iteration method introduced, considers each as weak classifier, iteratively increases number classifiers. Thus, optimal HSCF adaptively determined an end-to-end learning framework constructed. particular, improve classification performance, can be applied classical DNNs. Comprehensive experiments on eight datasets in several domains demonstrate effectiveness proposed method. The exhibits feasibility boosting DNNs with plasticity provides perspective for further developments source code available at https://github.com/Tough2011/HSCFNet.git .

Язык: Английский

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Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июнь 24, 2022

Parkinson’s disease (PD) is the second most common neurodegenerative characterized by motor dysfunction. Growing evidence has demonstrated that gut dysbiosis involved in occurrence, development and progression of PD. Numerous clinical trials have identified characteristics changed microbiota profiles, preclinical studies PD animal models indicated can influence onset via increasing intestinal permeability, aggravating neuroinflammation, aggregating abnormal levels α-synuclein fibrils, oxidative stress, decreasing neurotransmitter production. The be considered promising diagnostic therapeutic targets for PD, which regulated probiotics, psychobiotics, prebiotics, synbiotics, postbiotics, fecal transplantation, diet modifications, Chinese medicine. This review summarizes recent PD-associated profiles functions, potential roles, mechanisms microbiota-targeted interventions Deciphering underlying roles will help interpret pathogenesis from new perspectives elucidate novel strategies

Язык: Английский

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Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential

Ageing Research Reviews, Год журнала: 2023, Номер 91, С. 102077 - 102077

Опубликована: Сен. 24, 2023

Язык: Английский

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Metabolic reprogramming and polarization of microglia in Parkinson’s disease: Role of inflammasome and iron

Ageing Research Reviews, Год журнала: 2023, Номер 90, С. 102032 - 102032

Опубликована: Авг. 10, 2023

Язык: Английский

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Research on ferroptosis as a therapeutic target for the treatment of neurodegenerative diseases

Ageing Research Reviews, Год журнала: 2023, Номер 91, С. 102035 - 102035

Опубликована: Авг. 23, 2023

Ferroptosis is an iron- and lipid peroxidation (LPO)-mediated programmed cell death type. Recently, mounting evidence has indicated the involvement of ferroptosis in neurodegenerative diseases, especially Alzheimer's disease (AD), Parkinson's (PD), multiple sclerosis (MS), amyotrophic lateral (ALS), Huntington's (HD), so on. Treating presents opportunities as well challenges for diseases. This review provides a comprehensive overview underlying mechanisms that contribute to occurrence ferroptosis, their implications pathogenesis advancement major disorders. Meanwhile, we summarize interaction between other types diseases contribution corresponding drug development. In addition, specifically recent advances developing therapeutic means targeting these which may guide future approaches effective management devastating medical conditions.

Язык: Английский

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Mechanisms of ferroptosis in Alzheimer's disease and therapeutic effects of natural plant products: A review

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114312 - 114312

Опубликована: Май 19, 2023

Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by massive loss of specific neurons. It is a progressive disabling, severe and fatal complex disease. Due to its pathogenesis limitations clinical treatment strategies, it poses serious medical challenge burden worldwide. The AD not clear, potential biological mechanisms include aggregation soluble amyloid form insoluble plaques, abnormal phosphorylation tau protein formation intracellular neurofibrillary tangles (NFT), neuroinflammation, ferroptosis, oxidative stress metal ion disorders. Among them, ferroptosis newly discovered programmed cell death induced iron-dependent lipid peroxidation reactive oxygen species. Recent studies have shown that closely related AD, but the mechanism remains unclear. may be iron metabolism, amino acid metabolism affecting accumulation ions. Some chelating agents (deferoxamine, deferiprone), chloroiodohydroxyquine derivatives, antioxidants (vitamin E, lipoic acid, selenium), derivatives Fer-1, tet, etc. been in animal effective exert neuroprotective effects. This review summarizes regulation natural plant products on order provide reference information for future research development inhibitors.

Язык: Английский

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Iron homeostasis imbalance and ferroptosis in brain diseases

MedComm, Год журнала: 2023, Номер 4(4)

Опубликована: Июнь 26, 2023

Brain iron homeostasis is maintained through the normal function of blood-brain barrier and regulation at systemic cellular levels, which fundamental to brain function. Excess can catalyze generation free radicals Fenton reactions due its dual redox state, thus causing oxidative stress. Numerous evidence has indicated diseases, especially stroke neurodegenerative are closely related mechanism imbalance in brain. For one thing, diseases promote accumulation. another, accumulation amplifies damage nervous system exacerbates patients' outcomes. In addition, triggers ferroptosis, a newly discovered iron-dependent type programmed cell death, neurodegeneration received wide attention recent years. this context, we outline metabolism focus on current stroke, Alzheimer's disease, Parkinson's disease. Meanwhile, also discuss ferroptosis simultaneously enumerate drugs for chelators inhibitors.

Язык: Английский

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