Automatic and Early Detection of Parkinson’s Disease by Analyzing Acoustic Signals Using Classification Algorithms Based on Recursive Feature Elimination Method

Diagnostics, Год журнала: 2023, Номер 13(11), С. 1924 - 1924

Опубликована: Май 31, 2023

Parkinson's disease (PD) is a neurodegenerative condition generated by the dysfunction of brain cells and their 60-80% inability to produce dopamine, an organic chemical responsible for controlling person's movement. This causes PD symptoms appear. Diagnosis involves many physical psychological tests specialist examinations patient's nervous system, which several issues. The methodology method early diagnosis based on analysing voice disorders. extracts set features from recording voice. Then machine-learning (ML) methods are used analyse diagnose recorded distinguish cases healthy ones. paper proposes novel techniques optimize evaluating selected hyperparameter tuning ML algorithms diagnosing dataset was balanced synthetic minority oversampling technique (SMOTE) were arranged according contribution target characteristic recursive feature elimination (RFE) algorithm. We applied two algorithms, t-distributed stochastic neighbour embedding (t-SNE) principal component analysis (PCA), reduce dimensions dataset. Both t-SNE PCA finally fed resulting into classifiers support-vector machine (SVM), K-nearest neighbours (KNN), decision tree (DT), random forest (RF), multilayer perception (MLP). Experimental results proved that proposed superior existing studies in RF with algorithm yielded accuracy 97%, precision 96.50%, recall 94%, F1-score 95%. In addition, MLP 98%, 97.66%, 96%, 96.66%.

Язык: Английский

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Iron Deposition in Parkinson’s Disease: A Mini-Review

Cellular and Molecular Neurobiology, Год журнала: 2024, Номер 44(1)

Опубликована: Фев. 23, 2024

Iron deposition is crucial pathological changes observed in patients with Parkinson's disease (PD). Recently, scientists have actively explored therapeutic approaches targeting iron PD. However, several clinical studies failed to yield consistent results. In this review, we provide an overview of PD, from both basic research and perspectives. PD exhibit abnormalities various metabolism-related proteins, leading disruptions distribution, transport, storage, circulation, ultimately resulting deposition. Excess can induce oxidative stress iron-related cell death, exacerbate mitochondrial dysfunction, contributing the progression pathology. Magnetic resonance imaging indicated that characteristics brains vary. correlates symptoms different courses presentations display distinct patterns These may contribute diagnosis. a promising target for treatment. further required elucidate underlying mechanisms their impacts on

Язык: Английский

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m6A Demethylase FTO-Mediated Upregulation of BAP1 Induces Neuronal Ferroptosis via the p53/SLC7A11 Axis in the MPP⁺/MPTP-Induced Parkinson’s Disease Model

ACS Chemical Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the involvement of ferroptosis in its pathological mechanism. In this study, effects and mechanism BRCA1-associated protein 1 (BAP1) on neuronal PD were evaluated. Methods: A mouse model was constructed injecting mice with MPTP. Nissl staining, immunohistochemistry, immunofluorescence, Prussian blue staining evaluated histopathology iron distribution. The cell subjecting SK-N-SH cells to MPP+. m6A level BAP1 assessed MeRIP. mRNA levels BAP1, FTO, IGF2BP1, METTL3, YTHDF2, SLC7A11 utilizing RT-qPCR. Protein SLC7A11, p53 measured Western blot. Cell viability using CCK-8 assay, TUNEL used for assessing apoptosis. MDA, GSH, SOD, Fe2+ also measured. interactions among molecules verified RIP dual luciferase reporter ChIP assay. Results: treated MPP+ showed decrease overall BAP1. FTO facilitated demethylation leading an increased expression m6A-binding protein, YTHDF2 recognized decayed methylated reduced stability. FTO/BAP1 axis promoted MPP+-induced suppressing SLC7A11. collaboration p53, Knocking down mitigated MPTP model. Conclusion: m6A-mediated modification regulates cooperating Thus, may be potential therapeutic target treatment.

Язык: Английский

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Ferroptosis role in complexity of cell death: unrevealing mechanisms in Parkinson’s disease and therapeutic approaches

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Язык: Английский

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Role of iron in brain development, aging, and neurodegenerative diseases

Annals of Medicine, Год журнала: 2025, Номер 57(1)

Опубликована: Март 4, 2025

It is now understood that iron crosses the blood-brain barrier via a complex metabolic regulatory network and participates in diverse critical biological processes within central nervous system, including oxygen transport, energy metabolism, synthesis catabolism of myelin neurotransmitters. During brain development, distributed throughout brain, playing pivotal role key such as neuronal myelination, neurotransmitter synthesis. In physiological aging, can selectively accumulate specific regions, impacting cognitive function leading to intracellular redox imbalance, mitochondrial dysfunction, lipid peroxidation, thereby accelerating aging associated pathologies. Furthermore, accumulation may be primary contributor neurodegenerative diseases Alzheimer's Parkinson's diseases. Comprehending diseases, utilizing iron-sensitive Magnetic Resonance Imaging (MRI) technology for timely detection or prediction abnormal neurological states, implementing appropriate interventions instrumental preserving normal system function.

Язык: Английский

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Mechanisms of Ferroptosis and Emerging Links to the Pathology of Neurodegenerative Diseases

Frontiers in Aging Neuroscience, Год журнала: 2022, Номер 14

Опубликована: Июнь 28, 2022

Neurodegenerative diseases are a diverse class of attributed to chronic progressive neuronal degeneration and synaptic loss in the brain and/or spinal cord, including Alzheimer’s disease, Parkinson’s Huntington’s amyotrophic lateral sclerosis multiple sclerosis. The pathogenesis neurodegenerative is complex diverse, often involving mitochondrial dysfunction, neuroinflammation, epigenetic changes. However, has not been fully elucidated. Recently, accumulating evidence revealed that ferroptosis, newly discovered iron-dependent lipid peroxidation-driven type programmed cell death, provides another explanation for occurrence progression diseases. Here, we provide an overview process regulation mechanisms summarize current research progresses support contribution ferroptosis A comprehensive understanding emerging roles will shed light on development novel therapeutic technologies strategies slowing down these

Язык: Английский

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The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 154, С. 113611 - 113611

Опубликована: Сен. 5, 2022

Cerebrovascular diseases, such as ischemic stroke, pose serious medical challenges worldwide due to their high morbidity and mortality limitations in clinical treatment strategies. Studies have shown that reactive oxygen species (ROS)-mediated inflammation, excitotoxicity, programmed cell death of each neurovascular unit during post-stroke hypoxia reperfusion play an important role the pathological cascade. Ferroptosis, a characterized by iron-regulated accumulation lipid peroxidation, is caused abnormal metabolism lipids, glutathione (GSH), iron, can accelerate acute central nervous system injury. Recent studies gradually uncovered process ferroptosis stroke. Some drugs iron chelators, ferrostatin-1 (Fer-1) liproxstatin-1 (Lip-1) protect nerves after injury stroke inhibiting ferroptosis. In addition, combined with our previous on mediated natural compounds this review summarized progress regulation mechanism chemical components herbal recent years, order provide reference information for future research lead development inhibitors.

Язык: Английский

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Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июль 25, 2022

Ovarian cancer (OC) is one of the most common malignancies that causes death in women and a heterogeneous disease with complex molecular genetic changes. Because relatively high recurrence rate OC, it crucial to understand associated mechanisms drug resistance discover potential target for rational targeted therapy. Cell genetically determined process. Active orderly cell prevalent during development living organisms plays critical role regulating life homeostasis. Ferroptosis, novel type discovered recent years, distinct from apoptosis necrosis mainly caused by imbalance between production degradation intracellular lipid reactive oxygen species triggered increased iron content. Necroptosis regulated non-cysteine protease–dependent programmed necrosis, morphologically exhibiting same features as occurring via unique mechanism different apoptotic signaling pathway. Pyroptosis form characterized formation membrane pores subsequent lysis well release pro-inflammatory contents mediated abscisin family. Studies have shown ferroptosis, necroptosis, pyroptosis are involved progression variety diseases, including tumors. In this review, we summarized advances occurrence, development, therapeutic OC.

Язык: Английский

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Pathogenesis of α-Synuclein in Parkinson’s Disease: From a Neuron-Glia Crosstalk Perspective

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(23), С. 14753 - 14753

Опубликована: Ноя. 25, 2022

Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and rigidity, well non-motor anosmia, depression, cognitive impairment. Pathologically, the loss dopaminergic (DA) neurons in substantia nigra (SN) accumulation α-synuclein (α-syn)-composed Lewy bodies (LBs) neurites (LNs) are key hallmarks. Glia more than mere bystanders that simply support neurons, they actively contribute to almost every aspect neuronal development function; glial dysregulation has been implicated series diseases including PD. Importantly, amounting evidence added activation neuroinflammation new features onset progression. Thus, gaining better understanding glia, especially neuron-glia crosstalk, will not only provide insight into brain physiology events but also advance our knowledge pathologies. This review addresses current α-syn pathogenesis PD, with focus on crosstalk. Particularly, transmission between α-syn-induced activation, feedbacks DA neuron degeneration thoroughly discussed. In addition, aggregation, iron deposition, regulating ferroptosis covered. Lastly, we summarize preclinical clinical therapies, targeting treatments.

Язык: Английский

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Machine learning-based characterization of cuprotosis-related biomarkers and immune infiltration in Parkinson’s disease

Frontiers in Genetics, Год журнала: 2022, Номер 13

Опубликована: Окт. 17, 2022

Background: Parkinson’s disease (PD) is a neurodegenerative commonly seen in the elderly. On other hand, cuprotosis new copper-dependent type of cell death that can be observed various diseases. Methods: This study aimed to identify potential novel biomarkers by biomarker analysis and explore immune infiltration during onset cuprotosis. Gene expression profiles were retrieved from GEO database for GSE8397, GSE7621, GSE20163, GSE20186 datasets. Three machine learning algorithms: least absolute shrinkage selection operator (LASSO), random forest, support vector machine-recursive feature elimination (SVM-RFE) used screen signature genes cuprotosis-related (CRG). Immune was estimated ssGSEA, associated with cells function examined using spearman correlation analysis. Nomogram created validate accuracy these predicting PD progression. Classification specimens consensus clustering methods. Result: datasets Expression Omnibus (GEO) combined after eliminating batch effects. By we identified three ATP7A, SLC31A1, DBT or more accurate diagnosis course. Patients could benefit clinically characteristic line graph based on genes. Consistent two subtypes, C2 subtype exhibiting higher function. Conclusion: In conclusion, our reveals several newly intervene progression through infiltration.

Язык: Английский

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