The Role of Bioelectrical Patterns in Regulative Morphogenesis: An Evolutionary Simulation and Validation in Planarian Regeneration DOI Open Access

Sammy Hansali,

Léo Pio-Lopez,

Jennifer V. LaPalme

и другие.

Опубликована: Авг. 28, 2024

Endogenous bioelectrical patterns are an important regulator of anatomical pattern during embryogenesis, regeneration, and cancer. While there three known classes instructive bioelectric patterns: directly encoding, indirectly binary trigger, it is not how these design principles could be exploited by evolution what their relative advantages might be. To better understand the evolutionary role bioelectricity in homeostasis, we developed a neural cellular automaton (NCA). We used algorithms to optimize models achieve reliable morphogenetic driven different ways which tissues can interpret for downstream outcomes. found that: (1) All types codes allow reaching target morphologies; (2) Resetting change duration trigger alter morphogenesis; (3) Direct organisms show emergent robustness changes initial configurations; (4) Indirect perturbation; (5) indirect generalizability competency new (rotated) patterns; (6) repatterning post-developmental-phase. Because our simulation was fundamentally homeostatic system seeking specific goals state space, sought anxiolytics that reduced concern over distance those goals. simulated selective serotonin reuptake inhibitors, diminished ability artificial embryos correctly due altered organismal reward machinery, leading higher variance developmental outcomes, global morphological degradation, induced some bistability. These computational findings were validated data collected from vivo experiments SSRI exposure planarian flatworm regeneration.

Язык: Английский

Collective intelligence: A unifying concept for integrating biology across scales and substrates DOI Creative Commons

Patrick McMillen,

Michael Levin

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Март 28, 2024

Abstract A defining feature of biology is the use a multiscale architecture, ranging from molecular networks to cells, tissues, organs, whole bodies, and swarms. Crucially however, not only nested structurally, but also functionally: each level able solve problems in distinct problem spaces, such as physiological, morphological, behavioral state space. Percolating adaptive functionality one competent subunits higher functional organization requires collective dynamics: multiple components must work together achieve specific outcomes. Here we overview number biological examples at different scales which highlight ability cellular material make decisions that implement cooperation toward homeodynamic endpoints, intelligence by solving cell, tissue, whole-organism levels. We explore hypothesis province groups animals, an important symmetry exists between science swarms competencies cells other systems scales. then briefly outline implications this approach, possible impact tools field diverse for regenerative medicine synthetic bioengineering.

Язык: Английский

Процитировано

36
Principled Limitations on Self-Representation for Generic Physical Systems DOI Creative Commons
Chris Fields,

James F. Glazebrook,

Michael Levin

и другие.

Entropy, Год журнала: 2024, Номер 26(3), С. 194 - 194

Опубликована: Фев. 24, 2024

The ideas of self-observation and self-representation, the concomitant idea self-control, pervade both cognitive life sciences, arising in domains as diverse immunology robotics. Here, we ask a very general way whether, to what extent, these make sense. Using generic model physical interactions, prove theorem several corollaries that severely restrict applicable notions self-observation, self-control. We show, particular, adding observational, representational, or control capabilities meta-level component system cannot, even principle, lead complete representation whole. conclude self-representation can at best be heuristic, self models general, empirically tested by systems implement them.

Язык: Английский

Процитировано

11
Self-Improvising Memory: A Perspective on Memories as Agential, Dynamically Reinterpreting Cognitive Glue DOI Creative Commons
Michael Levin

Entropy, Год журнала: 2024, Номер 26(6), С. 481 - 481

Опубликована: Май 31, 2024

Many studies on memory emphasize the material substrate and mechanisms by which data can be stored reliably read out. Here, I focus complementary aspects: need for agents to dynamically reinterpret modify memories suit their ever-changing selves environment. Using examples from developmental biology, evolution, synthetic bioengineering, in addition neuroscience, propose that a perspective as preserving salience, not fidelity, is applicable many phenomena scales cells societies. Continuous commitment creative, adaptive confabulation, molecular behavioral levels, answer persistence paradox it applies individuals whole lineages. also speculate substrate-independent, processual view of life mind suggests memories, patterns excitable medium cognitive systems, could seen active sense-making process. explore diverse set embodied perspectives—nested who interpret each other’s own past messages actions best they (polycomputation). This synthesis unifying symmetries across disciplines, relevance research programs Diverse Intelligence engineering novel minds.

Язык: Английский

Процитировано

10
Life, its origin, and its distribution: a perspective from the Conway-Kochen Theorem and the Free Energy Principle DOI Creative Commons
Chris Fields, Michael Levin

Communicative & Integrative Biology, Год журнала: 2025, Номер 18(1)

Опубликована: Фев. 17, 2025

We argue here that the Origin of Life (OOL) problem is not just a chemistry but also, and primarily, cognitive science problem. When interpreted through lens Conway-Kochen theorem Free Energy Principle, contemporary physics characterizes all complex dynamical systems persist time as Bayesian agents. If persistent are to some – perhaps only minimal extent cognitive, alive, or living subset systems? no bright line can be drawn, we re-assess, from this perspective, Fermi paradox Drake equation. conclude improving our abilities recognize communicate with diverse intelligences in embodiments, whether based on familiar biochemistry not, will either resolve obviate OOL

Язык: Английский

Процитировано

2
Thoughts and thinkers: On the complementarity between objects and processes DOI
Chris Fields, Michael Levin

Physics of Life Reviews, Год журнала: 2025, Номер 52, С. 256 - 273

Опубликована: Янв. 18, 2025

Язык: Английский

Процитировано

1
Artificial Intelligences: A Bridge Toward Diverse Intelligence and Humanity's Future DOI Creative Commons
Michael Levin

Advanced Intelligent Systems, Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

Recent discussions and debate around artificial intelligence (AI) its status are notably incomplete, missing the implications of highly relevant aspects emerging fields diverse (DI) synthetic morphology, as well basic facts developmental biology. Herein, it is argued that human flourishing impossible without an appreciation space possible beings ways in which today's intelligent machine debates about universal existential questions facing biological beings, not just AI. The inevitable arrival a wide set unconventional bodies minds humans modify create new forms will disrupt untenable old narratives what people how to recognize their sentient allies unfamiliar guises. issues engendered by advent AI from perspective field DI evolutionary history discussed.

Язык: Английский

Процитировано

1
Electroceuticals: emerging applications beyond the nervous system and excitable tissues DOI Creative Commons
Swarnalatha Balasubramanian,

David A. Weston,

Michael Levin

и другие.

Trends in Pharmacological Sciences, Год журнала: 2024, Номер 45(5), С. 391 - 394

Опубликована: Апрель 18, 2024

Electroceuticals have evolved beyond devices manipulating neuronal signaling for symptomatic treatment, becoming more precise and disease modulating expanding the nervous system. These advancements promise transformative applications in arthritis, cancer tissue regeneration, more. Here, we discuss these recent advances offer insights future research.

Язык: Английский

Процитировано

9
Wireless control of nerve growth using bipolar electrodes: a new paradigm in electrostimulation DOI Creative Commons
Ann M. Rajnicek, N. Casañ-Pastor

Biomaterials Science, Год журнала: 2024, Номер 12(9), С. 2180 - 2202

Опубликована: Янв. 1, 2024

Electrical activity underpins all life, but is most familiar in the nervous system, where long range electrical signalling essential for function. When this lost (

Язык: Английский

Процитировано

8
AI-driven automated discovery tools reveal diverse behavioral competencies of biological networks DOI Creative Commons
Mayalen Etcheverry, Clément Moulin-Frier, Pierre-Yves Oudeyer

и другие.

eLife, Год журнала: 2025, Номер 13

Опубликована: Янв. 13, 2025

Many applications in biomedicine and synthetic bioengineering rely on understanding, mapping, predicting, controlling the complex behavior of chemical genetic networks. The emerging field diverse intelligence investigates problem-solving capacities unconventional agents. However, few quantitative tools exist for exploring competencies non-conventional systems. Here, we view gene regulatory networks (GRNs) as agents navigating a problem space develop automated to map robust goal states GRNs can reach despite perturbations. Our contributions include: (1) Adapting curiosity-driven exploration algorithms from AI discover range reachable GRNs, (2) Proposing empirical tests inspired by behaviorist approaches assess their navigation competencies. data shows that models inferred biological wide spectrum steady states, exhibiting various physiological network dynamics without requiring structural changes properties or connectivity. We also explore applicability these ‘behavioral catalogs’ comparing evolved across networks, designing drug interventions biomedical contexts bioengineering. These emphasis behavior-shaping open new paths efficiently For interactive version this paper, please visit https://developmentalsystems.org/curious-exploration-of-grn-competencies .

Язык: Английский

Процитировано

1
Stress sharing as cognitive glue for collective intelligences: A computational model of stress as a coordinator for morphogenesis DOI Creative Commons

Lakshwin Shreesha,

Michael Levin

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 731, С. 150396 - 150396

Опубликована: Июль 14, 2024

Individual cells have numerous competencies in physiological and metabolic spaces. However, multicellular collectives can reliably navigate anatomical morphospace towards much larger, reliable endpoints. Understanding the robustness control properties of this process is critical for evolutionary developmental biology, bioengineering, regenerative medicine. One mechanism that has been proposed enabling individual to coordinate toward specific morphological outcomes sharing stress (where a parameter reflects current amount error context homeostatic loop). Here, we construct analyze multiscale agent-based model morphogenesis which quantitatively examine impact on ability reach target morphology. We found improves morphogenetic efficiency collectives; populations with reached targets faster. Moreover, influenced future fate distant multi-cellular collective, enhancing cells' movement their radius influence, consistent hypothesis works increase cohesiveness collectives. During development, goal states could not be inferred from observation states, revealing limitations knowledge goals by an extern observer outside system itself. Taken together, our analyses support important role natural engineered systems seek robust large-scale behaviors emerge activity competent components.

Язык: Английский

Процитировано

6