In Vivo Seeding of Amyloid-β Protein and Implications in Modeling Alzheimer’s Disease Pathology DOI Creative Commons
Qing Liu,

Simin Song,

Lu Liu

и другие.

Biomolecules, Год журнала: 2025, Номер 15(4), С. 571 - 571

Опубликована: Апрель 11, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by extracellular plaques containing amyloid β-protein (Aβ) and intracellular neurofibrillary tangles formed tau. Cerebral Aβ accumulation initiates noxious cascade that leads to irreversible neuronal degeneration memory impairment in older adults. Recent advances seeding studies offer promising avenue for exploring the mechanisms underlying deposition complex pathological features of AD. However, extent which inoculated seeds can induce reproducible reliable manifestations remains unclear due significant variability across studies. In this review, we will discuss several factors contribute induction or acceleration consequent pathologies. Specifically, focus on diversity host animals, sources recipe seeds, inoculating strategies. By integrating these key aspects, review aims comprehensive perspective AD provide guidance modeling pathogenesis through exogenous introduction seeds.

Язык: Английский

Non-mutated human tau stimulates Alzheimer's disease-relevant neurodegeneration in a microglia-dependent manner DOI Creative Commons
Ethan R. Roy, Qiang Wang, Kexin Huang

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

Abstract The accumulation of abnormal, non-mutated tau protein is a key pathological hallmark Alzheimer’s disease (AD). Despite its strong association with progression, the mechanisms by which drives neurodegeneration in brain remain poorly understood. Here, we selectively expressed or mutated human microtubule-associated ( hMAPT ) neurons across and observed hippocampus, especially associated tau. Single-nuclei RNA sequencing confirmed selective loss hippocampal excitatory wild-type revealed upregulation neurodegeneration-related pathways affected populations. phosphorylated was accompanied cellular stress reactive gliosis multiple regions. Notably, lifelong absence microglia significantly differentially influenced extent hippocampus thalamus. Therefore, our study established an AD-relevant tauopathy mouse model, elucidated both neuron-intrinsic neuron-extrinsic responses, highlighted critical complex roles modulating tau-driven neurodegeneration.

Язык: Английский

Процитировано

0
Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer’s Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty Acids DOI Open Access
Mahsa Yavari, Nishan S. Kalupahana, Breanna N. Harris

и другие.

Nutrients, Год журнала: 2025, Номер 17(7), С. 1203 - 1203

Опубликована: Март 29, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and behavioral changes. It poses significant global health challenge. AD associated with the accumulation of amyloid-β (Aβ) plaques neurofibrillary tangles (NFTs) in brain, along chronic inflammation, dysfunctional neurons, synapse loss. While prevalence continues to rise, current FDA-approved drugs offer only limited effectiveness. Emerging evidence suggests that obesity, insulin resistance (IR), type 2 diabetes mellitus (T2DM) are also implicated pathogenesis, epidemiological studies animal models confirming impact IR on Aβ accumulation, high-fat diets exacerbating accumulation. Since neuroinflammation activated involves nuclear factor kappa-light-chain-enhancer B cell (NF-κB) pathway, inhibition NF-κB NLRP3 inflammasome activation potential therapeutic strategies AD. Bioactive compounds, including polyphenols (resveratrol, epigallocatechin-3-gallate, curcumin, quercetin), omega-3 polyunsaturated fatty acids, show promising results clinical trials for reducing levels, improving cognition modulating signaling pathways This review explores interplay between IR, pathology, emphasizing dietary compounds their role oxidative stress, as viable prevention treatment. By integrating findings, observational studies, trials, this aims provide comprehensive understating how metabolic dysfunctions bioactive influence progression.

Язык: Английский

Процитировано

0
Distinct factors drive the progression of tau pathology in Alzheimer's disease DOI Creative Commons
Yifan Luo,

Honglu Yu,

Keqiang Ye

и другие.

Fundamental Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
In Vivo Seeding of Amyloid-β Protein and Implications in Modeling Alzheimer’s Disease Pathology DOI Creative Commons
Qing Liu,

Simin Song,

Lu Liu

и другие.

Biomolecules, Год журнала: 2025, Номер 15(4), С. 571 - 571

Опубликована: Апрель 11, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by extracellular plaques containing amyloid β-protein (Aβ) and intracellular neurofibrillary tangles formed tau. Cerebral Aβ accumulation initiates noxious cascade that leads to irreversible neuronal degeneration memory impairment in older adults. Recent advances seeding studies offer promising avenue for exploring the mechanisms underlying deposition complex pathological features of AD. However, extent which inoculated seeds can induce reproducible reliable manifestations remains unclear due significant variability across studies. In this review, we will discuss several factors contribute induction or acceleration consequent pathologies. Specifically, focus on diversity host animals, sources recipe seeds, inoculating strategies. By integrating these key aspects, review aims comprehensive perspective AD provide guidance modeling pathogenesis through exogenous introduction seeds.

Язык: Английский

Процитировано

0