Drug-resistant epilepsy associated with peripheral complement decreases and sex-specific cytokine imbalances: a pilot study DOI Creative Commons

Nicole Pinzón-Hoyos,

Yibo Li, Monnie McGee

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 11, 2025

Drug-resistant epilepsy (DRE) presents significant challenges in treatment and management. While seizure-related alterations peripheral immune players are increasingly recognized, the involvement of complement system remains insufficiently explored DRE. We studied components their relationship to cytokine profiles serum samples from 46 DRE patients 45 matched healthy controls. examined relationships between these molecules clinical outcomes, including duration, intelligence scores, age. identified DRE-associated decreases, reduced levels C1q, Factor H, C4, C4b, C3, C3b/iC3b, as well elevated bFGF. females showed dysregulation classical pathway lower TNFα interleukin-8 compared females. males exhibited classical, lectin, terminal pathways, with trends increased CCL2 CCL5 males. Specific inflammatory markers (C2, IL-8, IL-9) correlated full-scale IQ scores patients. Our study reveals significantly circulating sex-specific imbalances. These findings suggest an underlying vulnerability that may be sex-dependent warrants further investigation

Язык: Английский

Drug-resistant epilepsy associated with peripheral complement decreases and sex-specific cytokine imbalances: a pilot study DOI Creative Commons

Nicole Pinzón-Hoyos,

Yibo Li, Monnie McGee

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 11, 2025

Drug-resistant epilepsy (DRE) presents significant challenges in treatment and management. While seizure-related alterations peripheral immune players are increasingly recognized, the involvement of complement system remains insufficiently explored DRE. We studied components their relationship to cytokine profiles serum samples from 46 DRE patients 45 matched healthy controls. examined relationships between these molecules clinical outcomes, including duration, intelligence scores, age. identified DRE-associated decreases, reduced levels C1q, Factor H, C4, C4b, C3, C3b/iC3b, as well elevated bFGF. females showed dysregulation classical pathway lower TNFα interleukin-8 compared females. males exhibited classical, lectin, terminal pathways, with trends increased CCL2 CCL5 males. Specific inflammatory markers (C2, IL-8, IL-9) correlated full-scale IQ scores patients. Our study reveals significantly circulating sex-specific imbalances. These findings suggest an underlying vulnerability that may be sex-dependent warrants further investigation

Язык: Английский

Процитировано

0