The microbiome’s influence on obesity: mechanisms and therapeutic potential DOI
Dawit Adisu Tadese, James Mwangi, Lei Luo

и другие.

Science China Life Sciences, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Язык: Английский

Identification of herbal drug extracts that promote growth of Akkermansia muciniphila in high-fat diet fed mice DOI
Shiho Fujisaka, Yoshiyuki Watanabe, Kazufumi Toume

и другие.

Diabetology International, Год журнала: 2024, Номер 15(3), С. 495 - 506

Опубликована: Апрель 6, 2024

Язык: Английский

Процитировано

1
Resveratrol: A Narrative Review Regarding Its Mechanisms in Mitigating Obesity‐Associated Metabolic Disorders DOI Open Access
Yichen Cai, Qiu Chen

Phytotherapy Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Resveratrol (RSV) is a naturally occurring astragalus-like polyphenolic compound with remarkable weight loss properties. However, the mechanism of RSV in treating obesity unclear. In this narrative review, we explored electronic databases (PubMed) for research articles from 2021 to present using keywords "resveratrol" and "obesity". This article explores mechanisms involved alleviation obesity-related metabolic disorders by RSV. affects modulating mitochondrial function, insulin signaling, gut microbiota, regulating lipid metabolism, inhibiting oxidative stress, epigenetic regulation. Administering pregnant animals exhibits maternal first-generation offspring benefits, administration lactating has long-term which involve modulations A comprehensive understanding regulation could help developing drugs suitable pregnancy preparation groups, women, nursing infants.

Язык: Английский

Процитировано

1
Impact of hepatocyte growth factor on the colonic morphology and gut microbiome in short bowel syndrome rat model DOI
K. Sugita, Keisuke Yano, Shun Onishi

и другие.

Pediatric Surgery International, Год журнала: 2024, Номер 40(1)

Опубликована: Июль 13, 2024

Язык: Английский

Процитировано

0
Isoxanthohumol improves hepatic lipid metabolism via regulating the AMPK/PPARα and PI3K/AKT signaling pathways in hyperlipidemic mice DOI Creative Commons
Yu Gao,

Qilong Zhou,

Huiqing Wang

и другие.

Food Science & Nutrition, Год журнала: 2024, Номер 12(11), С. 8846 - 8857

Опубликована: Сен. 10, 2024

Abstract Hyperlipidemia presents a significant global healthcare challenge, necessitating innovative therapeutic strategies for more effective outcomes. Recent studies have highlighted the beneficial impact of moderate beer intake on metabolic diseases. The purpose this research is to explore possible molecular mechanisms isoxanthohumol (IXN), major hop flavonoid in beer, treatment hyperlipidemia. mice model acute hyperlipidemia was constructed by intraperitoneal injection Triton WR‐1339. effect IXN assessed biochemical and histological analyses. Furthermore, comprehensive data mining across various public databases conducted identify underlying targets A protein–protein interaction network pinpoint hub targets, subsequent GO KEGG enrichment analyses were used elucidate biological functions. Molecular docking utilized validate binding affinity between IXN. Western blotting analysis further verified protein expression potential targets. administration significantly improved blood lipid hepatic levels, alongside increased SOD activity decreased MDA content mice. Histological analyses, including H&E Oil Red O staining, showed improvement steatosis with treatment. At level, levels p‐AMPK, PPARα, p‐PI3K, p‐AKT. activates AMPK/PPARα PI3K/AKT signaling pathways, leading reduction accumulation oxidative stress, ultimately ameliorating

Язык: Английский

Процитировано

0
Studies on the Probiotic, Adhesion, and Induction Properties of Artisanal Lactic Acid Bacteria: to Customize a Gastrointestinal Niche to Trigger Anti-obesity Functions DOI
Aslıhan KAMBER, Çisem Bulut Albayrak,

H S Harsa

и другие.

Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер unknown

Опубликована: Окт. 9, 2024

Язык: Английский

Процитировано

0
Oxidized Low-Density Lipoprotein Induces Reactive Oxygen Species-Dependent Proliferation of Intestinal Epithelial Cells DOI Creative Commons
Eddy E. González, Juan F. Burgueño,

María J. Leiva

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(11), С. 1466 - 1466

Опубликована: Ноя. 1, 2024

: Oxidized low-density lipoprotein (ox-LDL) is a proinflammatory particle associated with various diseases and affects cell proliferation viability in multiple types. However, its impact on intestinal epithelial cells remains underexplored. This study investigates the effect of ox-LDL colonic viability, as well underlying mechanisms involved.

Язык: Английский

Процитировано

0
Preparation, characterization, and ex vivo evaluation of isoxanthohumol nanosuspension DOI

M. Zhang,

Tianjiao Liu, Tan Ding

и другие.

International Journal of Pharmaceutics, Год журнала: 2024, Номер 667, С. 124909 - 124909

Опубликована: Ноя. 8, 2024

Язык: Английский

Процитировано

0
The microbiome’s influence on obesity: mechanisms and therapeutic potential DOI
Dawit Adisu Tadese, James Mwangi, Lei Luo

и другие.

Science China Life Sciences, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Язык: Английский

Процитировано

0