Crosstalk Between H-Type Vascular Endothelial Cells and Macrophages: A Potential Regulator of Bone Homeostasis DOI Creative Commons

Jiaxuan Fan,

Yaohui Xie,

Dayin Liu

и другие.

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 2743 - 2765

Опубликована: Фев. 1, 2025

The crosstalk between H-type endothelial cells (ECs) and macrophages is critical for maintaining angiogenesis osteogenesis in bone homeostasis. As core components of type H vessels, ECs respond to various pro-angiogenic signals, forming specialized vascular structures characterized by high expression platelet-endothelial cell adhesion molecule-1 (CD31) mucin (EMCN), thereby facilitating angiogenesis-osteogenesis coupling during formation. Macrophages, as key immune the perivascular region, are primarily classified into classically activated pro-inflammatory M1 phenotype selectively anti-inflammatory M2 phenotype, performing dual functions regulating local tissue homeostasis innate immunity. In recent years, complex vessel has garnered significant interest context bone-related diseases. Orderly regulation immunity provides a new direction preventing metabolic disorders such osteoporosis osteoarthritis. However, their interactions remain insufficiently understood, with limited clinical data available. This review comprehensively examines intricate diverse phenotypes, Insights signaling pathways that regulate crosstalk, focusing on roles osteogenesis. Furthermore, discusses interventions targeting this challenges remain. These insights may offer perspectives provide theoretical foundation developing novel therapeutic strategies.

Язык: Английский

Cooperation between inhibitory immune checkpoints of senescent cells with immunosuppressive network to promote immunosenescence and the aging process DOI Creative Commons
Antero Salminen

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102694 - 102694

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone? DOI Creative Commons
Lara Russo, Serena Babboni, Maria Grazia Andreassi

и другие.

Antioxidants, Год журнала: 2025, Номер 14(1), С. 99 - 99

Опубликована: Янв. 16, 2025

Cellular senescence is a state of permanent cell cycle arrest accompanied by metabolic activity and characteristic phenotypic changes. This process crucial for developing age-related diseases, where excessive calorie intake accelerates dysfunction aging. Overnutrition disturbs key pathways, including insulin/insulin-like growth factor signaling (IIS), the mammalian target rapamycin (mTOR), AMP-activated protein kinase. The dysregulation these pathways contributes to insulin resistance, impaired autophagy, exacerbated oxidative stress, mitochondrial dysfunction, further enhancing cellular systemic derangements. On other hand, dysfunctional endothelial cells adipocytes contribute inflammation, reduced nitric oxide production, altered lipid metabolism. Numerous factors, extracellular vesicles, mediate pathological communication between vascular system adipose tissue, amplifying imbalances. Meanwhile, caloric restriction (CR) emerges as potent intervention counteract overnutrition effects, improve function, reduce restore balance. CR modulates such IIS, mTOR, sirtuins, glucose metabolism, reducing promoting autophagy. can extend health span mitigate diseases delaying improving healthy endothelial-adipocyte interactions. review highlights crosstalk adipocytes, emphasizing potential in counteracting overnutrition-induced restoring homeostasis.

Язык: Английский

Процитировано

0
Metabolically unhealthy adipose tissue is characterized by reductions in mitochondrial size and function DOI Creative Commons

Darla DeStephanis,

Masha Long,

Abigail G. Williams

и другие.

Obesity, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Abstract Objective Adipose function, not mass, underpins metabolic health. Lean and obese nonhuman primates (NHPs) naturally develop syndrome. Mitochondria‐related measures in subcutaneous adipose tissue (SQ AT) peripheral blood mononuclear cells may elucidate differences that transcend adiposity measures. Methods Obesity statuses ranged from very lean to severely (<9%–>50%, n = 44), which were equivalent healthy or unhealthy NHPs (metabolic syndrome score difference, p < 0.001). We evaluated SQ AT histology, electron microscopy, proteins, bioenergetics. Results Unhealthy adipocytes had mitochondria one‐half the size of ( 0.01), whereas adipocyte cell sizes comparable. Consistent with small mitochondria, we saw deficiencies mitochondrial fusion quality‐control proteins (all 0.05). Smaller consistent low respiration Mitochondrial was specifically reduced unhealthiness, as abundance, size, related metrics unrelated adiposity. Isolated stromal vascular showed comparable respirometry profiles, substantiating specificity adipocyte‐related defects. Peripheral bioenergetic indices increased NHPs, indicative immune activation, correlated inflammatory cytokines. Conclusions conclude targeting processes would be a rational strategy improve health, independent total fat mass.

Язык: Английский

Процитировано

0
Crosstalk Between H-Type Vascular Endothelial Cells and Macrophages: A Potential Regulator of Bone Homeostasis DOI Creative Commons

Jiaxuan Fan,

Yaohui Xie,

Dayin Liu

и другие.

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 2743 - 2765

Опубликована: Фев. 1, 2025

The crosstalk between H-type endothelial cells (ECs) and macrophages is critical for maintaining angiogenesis osteogenesis in bone homeostasis. As core components of type H vessels, ECs respond to various pro-angiogenic signals, forming specialized vascular structures characterized by high expression platelet-endothelial cell adhesion molecule-1 (CD31) mucin (EMCN), thereby facilitating angiogenesis-osteogenesis coupling during formation. Macrophages, as key immune the perivascular region, are primarily classified into classically activated pro-inflammatory M1 phenotype selectively anti-inflammatory M2 phenotype, performing dual functions regulating local tissue homeostasis innate immunity. In recent years, complex vessel has garnered significant interest context bone-related diseases. Orderly regulation immunity provides a new direction preventing metabolic disorders such osteoporosis osteoarthritis. However, their interactions remain insufficiently understood, with limited clinical data available. This review comprehensively examines intricate diverse phenotypes, Insights signaling pathways that regulate crosstalk, focusing on roles osteogenesis. Furthermore, discusses interventions targeting this challenges remain. These insights may offer perspectives provide theoretical foundation developing novel therapeutic strategies.

Язык: Английский

Процитировано

0