Aquaculture, Год журнала: 2024, Номер 596, С. 741721 - 741721
Опубликована: Окт. 9, 2024
Язык: Английский
Cellular Signalling, Год журнала: 2025, Номер 127, С. 111589 - 111589
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
1
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Окт. 28, 2024
Background Prematurity or low birth weight (LBW), poses a significant challenge in global health. Exploring appropriate and effective nutritional interventions is crucial for the growth development of LBW infants. Hydrolyzed protein formula has been suggested as potential solution to prevent intestinal dysfunction improve digestion absorption Objectives This study aimed investigate benefits hydrolyzed on feeding intolerance, morphological development, microbiota piglet model. Methods A total 24 male piglets (3 d age, 0.95–1.25 kg average BW) were assigned (8 pens/diet; 1 pigs/pen) into three dietary treatments fed with basic (BF), standard premature infant (SF) (HF) respectively, 7 d. After sacrifice, performance, amino acid metabolism morphology assessed. 16S rRNA sequencing microbial metabolic phenotypes analyzed effects different flora structure piglets. Results The HF diet reduced rates diarrhea milk vomiting by 20.44% ( p > 0.05) 58.44% 0.05), decreased crypt depth ileum while increasing ratio villus height/crypt mRNA expressions y+ LAT1 b0,+ AT < 0.05). increased final body weight, serum Thr essential contents, CAT2 ileal mucosa compared SF Microbiota results showed that colonic richness indices (Chao1, ACE, observed species), diversity (Shannon Simpson), phyla Actinobacteriota, unidentified_Bacteria, Acidobacteriota Actinobacteria, genus Rubrobacter RB41 groups. Microbial analysis reduction biofilm-forming bacteria Conclusion In summary, had better nutrition tolerance suckling improving transport regulating gut communities.
Язык: Английский
Процитировано
7
Health Science Reports, Год журнала: 2025, Номер 8(1)
Опубликована: Янв. 1, 2025
ABSTRACT Background and Aim The high rate of tumor growth results in an increased need for amino acids. As solute carriers (SLC) transporters are capable transporting different acids, cancer may develop as a result these transporters' over‐expression due to their complex formation with other biological molecules. Therefore, this review investigated the role SLC progression cancer. Methods We retrieved data from Google Scholar, Web Science, PubMed, Cochrane Library, EMBASE regarding influence human SLCs on development Articles published English before August 2024 were included study. Results overexpression is strongly related cell proliferation angiogenesis number types including thyroid, pancreatic, lung, hepatocellular, colon cancers. They crucial stimulation several signaling pathways, particularly mTOR kinase activity, which starts cascade, protein synthesis, growth, proliferation, inhibits apoptosis cancerous cells. Furthermore, they contribute activation PI3K/AKT signaling, has impact invasion, death Thus, become potential therapeutic target that plays drug resistance, microenvironment regulation, modulation immune response. Conclusion recognized progression. confirm our findings, case‐control study required investigate acid development.
Язык: Английский
Процитировано
0
BMC Urology, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 18, 2025
Prostate cancer (PCa) is one of the most common malignancies in men worldwide. Despite advances treatment, many patients develop resistance to conventional therapies. Solute carrier (SLC) proteins, as transmembrane transporters, have recently emerged potential therapeutic targets due their role tumor metabolism and progression. This review summarizes key roles six SLC proteins PCa, including involvement metabolic reprogramming, regulation signaling pathways, effects on microenvironment. Although targeting family members prostate remains an underexplored area, growing body evidence suggests that it holds for future development.
Язык: Английский
Процитировано
0
Bioorganic Chemistry, Год журнала: 2025, Номер 159, С. 108343 - 108343
Опубликована: Март 9, 2025
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Март 8, 2025
Solid tumors develop within a complex environment called the tumor microenvironment (TME), which is sculpted by presence of other cells, such as cancer-associated fibroblasts (CAFs) and immune cells like macrophages (Mφs). Despite orchestrate tumor-supportive through intricate interaction with components TME. However, specific mechanism this intercellular dialogue regulated not fully understood. To that end, development an organotypic 3D breast TME-on-a-chip (TMEC) model, integrated single-cell RNA sequencing analysis, reported to mechanistically evaluate progression triple-negative cancer (TNBC) in patient-derived CAFs Mφs. Extensive functional assays, including invasion morphometric characterization, reveal synergistic influence Mφs on cells. Furthermore, gene expression pathway enrichment analyses identify involvement KYNU gene, suggesting potential evasion kynurenine pathway. Lastly, pharmacological targeting identified investigated.
Язык: Английский
Процитировано
0
Genes, Год журнала: 2025, Номер 16(4), С. 463 - 463
Опубликована: Апрель 18, 2025
Background: Pancreatic ductal adenocarcinoma (PDAC), a challenging and malignant cancer, primarily originates from the exocrine cells of pancreas. The superfamily solute carrier (SLC) transporters, consisting more than 450 proteins divided into 65 families, is integral to various cellular processes represents promising target in precision oncology. As therapeutic targets, SLC transporters are explored through an integrative analysis. Materials Methods: expression profiles SLCs were systematically analyzed using mRNA data Cancer Genome Atlas (TCGA) protein Human Protein (HPA). Survival analysis was examined evaluate prognostic significance for overall survival (OS) disease-specific (DSS). Genetic alterations cBioPortal, while structural studies performed with AlphaFold AlphaMissense predict functional impacts. Furthermore, Gene Set Enrichment Analysis (GSEA) carried out identify oncogenic pathways linked transporter expression. Results: significantly upregulated tumors relative normal tissues. Higher levels SLC39A10 (HR = 1.89, p 0.0026), SLC22B5 1.84, 0.0042), SLC55A2 2.15, 0.00023), SLC30A6 1.90, 0.003) strongly associated unfavorable OS, highlighting their connection poor prognosis PDAC. GSEA highlighted that these four involved key pathways, such as epithelial–mesenchymal transition (EMT), TNF-α signaling, angiogenesis. Conclusions: study identifies targets PDAC, crucial role essential metabolic pathways. These findings lay groundwork developing next-generation anti-cancer treatment improve PDAC patients.
Язык: Английский
Процитировано
0
Experimental Cell Research, Год журнала: 2025, Номер 448(2), С. 114567 - 114567
Опубликована: Апрель 21, 2025
Язык: Английский
Процитировано
0
Animals, Год журнала: 2024, Номер 14(17), С. 2569 - 2569
Опубликована: Сен. 4, 2024
This study systematically investigated the effects of tea polyphenols on methane (CH4) production and rumen epithelial cell transport capability in cattle using both vitro animal experiments, employing multi-omics techniques. The results demonstrated that, compared to control group, significantly reduced CH4 acetate/propionate ratio (p < 0.05). Tea by inhibiting relative abundance unclassified_d_Archaea methanogens protozoa Pseudoentodinium g__Balantioides. experiments showed that increased concentrations T-AOC GSH-PX bovine blood In addition, microbial groups such as Rikenellaceae_RC9_gut_group, Ruminococcaceae_NK4A214_group, Butyrivibrio_2 were enriched ruminal fluid polyphenol group proteomic indicated significant upregulation proteins COIII, S100A8, FABP1, SLC2A8, SLC29A1 0.05) downregulation including HBB, RAB4A, RBP4, LOC107131172, HBA, ZFYVE19 0.05), with FABP1 showing a positive correlation propionate concentration, RAB4A had negative Overall, modulate composition within rumen, enhancing host’s capacity for volatile fatty acids.
Язык: Английский
Процитировано
2
Cancers, Год журнала: 2024, Номер 16(18), С. 3226 - 3226
Опубликована: Сен. 22, 2024
: Head and neck squamous cell carcinoma (HNSC) is the most prevalent cancer in head region, originating from mucosal epithelium of oral cavity, pharynx, larynx. The solute carrier (SLC) transporter superfamily, consisting over 400 proteins across 65 families, plays a crucial role cellular functions presents promising targets precision oncology. This study aims to analyze expression SLC transporters HNSC their potential as biomarkers therapeutic targets.
Язык: Английский
Процитировано
1