Polycyclic aromatic compounds,
Год журнала:
2021,
Номер
42(10), С. 7686 - 7696
Опубликована: Ноя. 28, 2021
In
this
research
a
new
derivatives
of
3,3,5-trichloroisatins
and
3,3-dichloroisatins
were
synthesized
in
good
yields
using
catalyst-free
one-pot
reaction
isatins
or
N-alkylisatines,
triphenylphosphine
carbon
tetrachloride
acetonitrile
at
room
temperature.
Because
existing
isatin
core
compounds,
the
antioxidant
activity
was
investigated
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
radical
scavenging
power
compounds
for
reducing
ferric
ion
experiments
comparing
results
with
synthetic
antioxidants
(TBHQ
BHT).
Easy,
simple,
fast
procedure
are
some
advantages
study.
Molecules,
Год журнала:
2025,
Номер
30(2), С. 430 - 430
Опубликована: Янв. 20, 2025
A
thiazolo-pyrimidinone
derivative
library
was
developed
through
a
facile
solid-phase
synthesis
method.
For
the
reaction,
thiazolo[4,5-d]pyrimidin-7(6H)-one
structure
synthesized
efficient
Thorpe–Ziegler
and
cyclization
reactions.
The
with
diversity
of
three
had
total
four
steps
57
compounds.
In
addition,
yield
per
step
65–97%,
which
very
high.
method
compounds
will
be
used
to
find
biological
activity
thiazole
structure–activity
relationship.
Cumhuriyet Science Journal,
Год журнала:
2025,
Номер
46(1), С. 41 - 47
Опубликована: Март 25, 2025
In
this
study,
3-hydrazinoindolin-2-one
(S),
an
isatin
monohydrazone
compound,
was
synthesized.
Spectroscopic
(IR
and
1H-NMR)
analyses
were
performed
for
the
synthesized
compound.
To
compare
experimental
spectroscopic
data
obtained,
optimized
at
B3LYP/6-31G(d,p).
The
calculated
found
to
be
compatible
with
obtained
structural
analysis.
Contour
diagrams
MEP
maps
also
identify
electrophilic
nucleophilic
attack
sites
of
synthesis
evaluate
their
compatibility
biomolecular
system,
compounds
fused
target
protein
representing
MCF-7
cell
line.
PDB
ID
compound:
1M17
3HY3
as
-5.70
-5.73
kcal/mol
proteins,
respectively.
Based
on
molecular
docking
parameters,
it
determined
suitable
anti-cancer
applications
Polycyclic aromatic compounds,
Год журнала:
2021,
Номер
42(10), С. 7686 - 7696
Опубликована: Ноя. 28, 2021
In
this
research
a
new
derivatives
of
3,3,5-trichloroisatins
and
3,3-dichloroisatins
were
synthesized
in
good
yields
using
catalyst-free
one-pot
reaction
isatins
or
N-alkylisatines,
triphenylphosphine
carbon
tetrachloride
acetonitrile
at
room
temperature.
Because
existing
isatin
core
compounds,
the
antioxidant
activity
was
investigated
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
radical
scavenging
power
compounds
for
reducing
ferric
ion
experiments
comparing
results
with
synthetic
antioxidants
(TBHQ
BHT).
Easy,
simple,
fast
procedure
are
some
advantages
study.
