European Journal of Life Sciences,
Год журнала:
2025,
Номер
4(1), С. 24 - 35
Опубликована: Апрель 30, 2025
Algae
have
become
the
center
of
attention
due
to
their
strong
antioxidants
and
enzyme-inhibitory
activities.
In
this
study,
green
algae
(Enteromorpha
linza)
extracts
obtained
using
acetone,
hexane
methanol
were
investigated.
antioxidant
properties,
anti-acetylcholinesterase
(AChE)
potential,
ADME
estimations
molecular
docking
analyses
The
best
binding
position
was
by
sirsimaritin,
daidzein,
kaempferol,
morin
myricetin
active
site
acetylcholinesterase
receptor.
Docking
score
values
calculated
as
-10.0,
-10.3,
-9.9,
-9.8
kcal/mol,
respectively.
Experimental
analysis
revealed
that
showed
inhibitory
activity
against
enzyme.
Acetone
extract
good
inhibition
performance
with
IC50
0.0379
mg/ml
0.0414
mg/ml,
value
for
determined
0.997
mg/ml.
When
results
evaluated
in
terms
both
DPPH
ABTS
radical
scavenging
capacities,
it
acetone-based
had
a
higher
capacity
(DPPH:
17.48%,
ABTS:
83.58%)
compared
other
solvents.
general,
examined
can
be
used
source
natural
agents
beneficial
human
health.
Results in Chemistry,
Год журнала:
2024,
Номер
7, С. 101503 - 101503
Опубликована: Янв. 1, 2024
Alzheimer's
dementia
(AD),
the
most
prevalent
neurodegenerative
disorder
adversely
affecting
elderly
citizens
worldwide,
is
an
incurable
with
no
effective
medication
found
till
date.
Taking
into
account
seriousness
of
this
issue,
imidazopyridine-based
benzothiazole-oxadiazole
hybrid
derivatives
were
synthesized
as
anti-Alzheimer's
agents.
The
efficacy
these
scaffolds
was
compared
standard
Donepezil
(IC50
=
14.47
±
1.20
μM
for
AChE
and
19.90
2.40
BuChE).
All
novel
exhibited
biological
activity
covering
a
range
IC50
6.70
1.65
41.65
7.20
6.40
1.80
44.65
7.40
BuChE.
Analog
6p
having
BuChE
lead
candidate
series
maximum
inhibition
due
to
presence
small
sized
highly
electronegative
fluoro
moieties,
inhibiting
enzymes
through
hydrogen
bonds.
These
interactions
also
studied
in
molecular
docking
investigations
compounds.
Furthermore,
ADME
analysis
conducted
study
assisted
drug
likeness
potent
analogs.
Synthetic
structural
confirmation
achieved
13C
NMR,
1H
NMR
HREI-MS.
Heliyon,
Год журнала:
2024,
Номер
10(12), С. e33150 - e33150
Опубликована: Июнь 1, 2024
In
the
previous
study,
synthesis
and
characterization
of
4-(3-fluorophenyl)-3-thiosemicarbazide
benzaldehyde
derivatives
based
thiosemicarbazone
ligands
their
Co(II),
Ni(II),
Cu(II),
Zn(II)
complexes
were
carried
out
to
evaluate
malarial
oxidant
inflammatory
inhibition
abilities,
demonstrating
that
these
compounds
have
robust
efficacy
for
ailments.
present
research,
find
a
combating
agent
against
breast
cancer,
tuberculosis,
bacterial
fungal
ailments,
tested
through
MTT,
microplate
alamar
blue
serial
dilution
protocols.
ADMET
DFT
investigation
analyzed
highly
bioactive
(2,
7–10)
give
new
insight
about
compound's
reactivity,
stability
drug
likeness
properties.
Furthermore,
activity
results
shows
ligand
(2)
its
demonstrate
greater
compared
(1)
complexes.
The
Cu(II)
(9)
(10)
observed
as
efficient
cancer
(MCF-7
cell
line),
TB
(H37Rv
strain),
ailments
in
comparison
standard
drugs
with
0.029
±
0.001
μM
IC50
value
anticancer
0.0034
0.0017
μmol/mL
MIC
anti-tuberculosis
activity.
molecular
docking
investigation,
various
kind
binding
interactions
lowest
affinity
(against
4RJ3
(−10.0
kcal/mol),
2VCJ
(−7.9
kcal/mol))
(−7.8
−8.3
kcal/mol
5V3Y
3PTY
protein)
support
bioactivity.
This
research
highlights
pharmaceutical
importance
transition
metal
having
thiosemicarbazones,
presenting
significant
approach
discovery
potent
anti-infectious
agent.
