European Journal of Life Sciences,
Год журнала:
2025,
Номер
4(1), С. 24 - 35
Опубликована: Апрель 30, 2025
Algae
have
become
the
center
of
attention
due
to
their
strong
antioxidants
and
enzyme-inhibitory
activities.
In
this
study,
green
algae
(Enteromorpha
linza)
extracts
obtained
using
acetone,
hexane
methanol
were
investigated.
antioxidant
properties,
anti-acetylcholinesterase
(AChE)
potential,
ADME
estimations
molecular
docking
analyses
The
best
binding
position
was
by
sirsimaritin,
daidzein,
kaempferol,
morin
myricetin
active
site
acetylcholinesterase
receptor.
Docking
score
values
calculated
as
-10.0,
-10.3,
-9.9,
-9.8
kcal/mol,
respectively.
Experimental
analysis
revealed
that
showed
inhibitory
activity
against
enzyme.
Acetone
extract
good
inhibition
performance
with
IC50
0.0379
mg/ml
0.0414
mg/ml,
value
for
determined
0.997
mg/ml.
When
results
evaluated
in
terms
both
DPPH
ABTS
radical
scavenging
capacities,
it
acetone-based
had
a
higher
capacity
(DPPH:
17.48%,
ABTS:
83.58%)
compared
other
solvents.
general,
examined
can
be
used
source
natural
agents
beneficial
human
health.
Frontiers in Bioinformatics,
Год журнала:
2025,
Номер
5
Опубликована: Фев. 13, 2025
Antibodies
are
naturally
produced
safeguarding
proteins
that
the
immune
system
generates
to
fight
against
invasive
invaders.
For
centuries,
they
have
been
artificially
and
utilized
eradicate
various
infectious
diseases.
Given
ongoing
threat
posed
by
COVID-19
pandemics
worldwide,
antibodies
become
one
of
most
promising
treatments
prevent
infection
save
millions
lives.
Currently,
in
silico
techniques
provide
an
innovative
approach
for
developing
antibodies,
which
significantly
impacts
formulation
antibodies.
These
develop
with
great
specificity
potency
diseases
such
as
SARS-CoV-2
using
computational
tools
algorithms.
Conventional
methods
designing
frequently
costly
time-consuming.
However,
offers
a
contemporary,
effective,
economical
paradigm
creating
next-generation
especially
accordance
recent
developments
bioinformatics.
By
utilizing
multiple
antibody
databases
high-throughput
approaches,
unique
construct
can
be
designed
,
facilitating
accurate,
reliable,
secure
development
human
use.
Compared
their
traditionally
developed
equivalents,
large
number
-designed
advanced
swiftly
clinical
trials
became
accessible
sooner.
This
article
helps
researchers
more
quickly
affordably
giving
them
access
current
information
on
approaches
creation.
European Journal of Life Sciences,
Год журнала:
2025,
Номер
4(1), С. 24 - 35
Опубликована: Апрель 30, 2025
Algae
have
become
the
center
of
attention
due
to
their
strong
antioxidants
and
enzyme-inhibitory
activities.
In
this
study,
green
algae
(Enteromorpha
linza)
extracts
obtained
using
acetone,
hexane
methanol
were
investigated.
antioxidant
properties,
anti-acetylcholinesterase
(AChE)
potential,
ADME
estimations
molecular
docking
analyses
The
best
binding
position
was
by
sirsimaritin,
daidzein,
kaempferol,
morin
myricetin
active
site
acetylcholinesterase
receptor.
Docking
score
values
calculated
as
-10.0,
-10.3,
-9.9,
-9.8
kcal/mol,
respectively.
Experimental
analysis
revealed
that
showed
inhibitory
activity
against
enzyme.
Acetone
extract
good
inhibition
performance
with
IC50
0.0379
mg/ml
0.0414
mg/ml,
value
for
determined
0.997
mg/ml.
When
results
evaluated
in
terms
both
DPPH
ABTS
radical
scavenging
capacities,
it
acetone-based
had
a
higher
capacity
(DPPH:
17.48%,
ABTS:
83.58%)
compared
other
solvents.
general,
examined
can
be
used
source
natural
agents
beneficial
human
health.
