Antioxidant, anti-acetylcholinesterase potentials, ADME estimations and molecular docking studies of green algae extracts DOI
Olgun Çirak, Adem Necip, Mesut Işık

и другие.

European Journal of Life Sciences, Год журнала: 2025, Номер 4(1), С. 24 - 35

Опубликована: Апрель 30, 2025

Algae have become the center of attention due to their strong antioxidants and enzyme-inhibitory activities. In this study, green algae (Enteromorpha linza) extracts obtained using acetone, hexane methanol were investigated. antioxidant properties, anti-acetylcholinesterase (AChE) potential, ADME estimations molecular docking analyses The best binding position was by sirsimaritin, daidzein, kaempferol, morin myricetin active site acetylcholinesterase receptor. Docking score values calculated as -10.0, -10.3, -9.9, -9.8 kcal/mol, respectively. Experimental analysis revealed that showed inhibitory activity against enzyme. Acetone extract good inhibition performance with IC50 0.0379 mg/ml 0.0414 mg/ml, value for determined 0.997 mg/ml. When results evaluated in terms both DPPH ABTS radical scavenging capacities, it acetone-based had a higher capacity (DPPH: 17.48%, ABTS: 83.58%) compared other solvents. general, examined can be used source natural agents beneficial human health.

Язык: Английский

Spectroscopic and Quantum chemical studies of some novel mixed-ligand complexes of vanadium and Comparative evaluation of their antimicrobial and antioxidant activities DOI

Kulsum Hashmi,

Smita Rai, Swati Sharma

и другие.

Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 113967 - 113967

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Unlocking the potential of in silico approach in designing antibodies against SARS-CoV-2 DOI Creative Commons

Tasshitra R. Subramaniam,

Siti Aisyah Mualif, Weng Howe Chan

и другие.

Frontiers in Bioinformatics, Год журнала: 2025, Номер 5

Опубликована: Фев. 13, 2025

Antibodies are naturally produced safeguarding proteins that the immune system generates to fight against invasive invaders. For centuries, they have been artificially and utilized eradicate various infectious diseases. Given ongoing threat posed by COVID-19 pandemics worldwide, antibodies become one of most promising treatments prevent infection save millions lives. Currently, in silico techniques provide an innovative approach for developing antibodies, which significantly impacts formulation antibodies. These develop with great specificity potency diseases such as SARS-CoV-2 using computational tools algorithms. Conventional methods designing frequently costly time-consuming. However, offers a contemporary, effective, economical paradigm creating next-generation especially accordance recent developments bioinformatics. By utilizing multiple antibody databases high-throughput approaches, unique construct can be designed , facilitating accurate, reliable, secure development human use. Compared their traditionally developed equivalents, large number -designed advanced swiftly clinical trials became accessible sooner. This article helps researchers more quickly affordably giving them access current information on approaches creation.

Язык: Английский

Процитировано

0

Experimental and computational study of Ni(II) and Zn(II) complexes of isatin-3-thiosemicarbazone: Structure, biological activity and ct-DNA binding study DOI
Qurat Ul Ain, Iqubal Singh, Kamaldeep Paul

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141846 - 141846

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

Sonochemical Synthesis, Structural Elucidation, and Photocatalytic Efficiency of Ag(I) and Ni(Ii) Schiff Base Complexes in the Degradation of Methylene Blue Dye Under Visible Light DOI

Aml M. Saleh,

Amal G. Mahdy,

Leila M. Abbass

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Antioxidant, anti-acetylcholinesterase potentials, ADME estimations and molecular docking studies of green algae extracts DOI
Olgun Çirak, Adem Necip, Mesut Işık

и другие.

European Journal of Life Sciences, Год журнала: 2025, Номер 4(1), С. 24 - 35

Опубликована: Апрель 30, 2025

Algae have become the center of attention due to their strong antioxidants and enzyme-inhibitory activities. In this study, green algae (Enteromorpha linza) extracts obtained using acetone, hexane methanol were investigated. antioxidant properties, anti-acetylcholinesterase (AChE) potential, ADME estimations molecular docking analyses The best binding position was by sirsimaritin, daidzein, kaempferol, morin myricetin active site acetylcholinesterase receptor. Docking score values calculated as -10.0, -10.3, -9.9, -9.8 kcal/mol, respectively. Experimental analysis revealed that showed inhibitory activity against enzyme. Acetone extract good inhibition performance with IC50 0.0379 mg/ml 0.0414 mg/ml, value for determined 0.997 mg/ml. When results evaluated in terms both DPPH ABTS radical scavenging capacities, it acetone-based had a higher capacity (DPPH: 17.48%, ABTS: 83.58%) compared other solvents. general, examined can be used source natural agents beneficial human health.

Язык: Английский

Процитировано

0