The Journal of Physical Chemistry Letters,
Год журнала:
2024,
Номер
unknown, С. 12129 - 12137
Опубликована: Ноя. 27, 2024
It
is
a
critical
and
broad
prospect
to
evaluate
ion
levels
monitor
their
dynamic
changes
in
the
brain
for
early
diagnosis,
in-depth
mechanism
investigation,
accurate
staging
of
neurodegenerative
diseases
including
Alzheimer's
disease
(AD).
still
great
challenge
vivo
track
Zn
Achieving
highly
selective
detections
of
Ag+
and
Hg2+
is
great
importance
because
their
excessive
emission
can
cause
many
diseases.
Herein,
a
novel
large
Stokes
shift
fluorescent
probe
DKT
based
on
dansyl
fluorophore
modified
peptide
biomolecules
(NH2-Thr-Lys-Thr-NH2)
was
successfully
synthesized
with
high
yield,
which
simultaneously
detect
(turn
on)
off)
different
response
patterns
in
100%
aqueous
solution.
also
enables
quantitative
detection
LODs
37.1
nM
26.7
nM,
respectively.
Besides,
ESI-HRMS
spectra,
Job's
plot,
fluorometric
titration
confirmed
that
the
binding
stoichiometry
determined
to
be
2:
1
between
Ag+/Hg2+.
Moreover,
has
good
fluorescence
stability
rapidly
detected
over
wide
pH
range.
Furthermore,
applied
three
actual
water
samples,
tea
samples
watermelon
juice,
exhibited
potential
for
accuracy
environmental
monitoring
quality
control.
Additionally,
results
bioimaging
showed
had
significant
distinguishing
ability
living
cells
zebrafish.
More
importantly,
smartphone
platform
not
only
provides
reliable
new
method
field
Hg2+,
but
expands
its
application
prospect
heavy
metal
ions
pollution
detection.
Abstract
A
simple
naphthalimide‐based
fluorescent
probe
was
designed
and
synthesized
for
the
determination
of
mercury
ion
(Hg
2+
).
The
showed
a
noticeable
fluorescence
quenching
response
Hg
.
When
added
with
,
intensity
at
560
nm
remarkably
decreased
color
changed
from
yellow
to
colorless
under
ultraviolet
(UV)
light.
had
notable
selectivity
sensitivity
displayed
an
excellent
sensing
performance
when
detecting
low
concentration
(19.5
nM).
binding
phenomenon
between
identified
by
Job's
method
high‐resolution
mass
spectrometry
(HRMS).
Moreover,
not
only
utilized
identify
in
real
samples
satisfactory
results
(92.00%–110.00%)
but
also
successfully
used
bioimaging
cells
zebrafish.
recognition
mechanism
has
been
verified
transmission
electron
microscopy
(TEM)
first
time.
All
that
could
be
as
potent
useful
tool
detection