Preparation, Characterization, and Antibacterial Activity of Amino Acids Grafted‐Chitosan/Glycerophosphate Hydrogel DOI

Su Ping Dai,

Hui Yun Zhou,

Li Jun Ren

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(45)

Опубликована: Ноя. 28, 2024

Abstract In this paper, L‐lysine (Lys), L‐glutamic acid (Glu), and L‐glutamine (Gln) ‐grafted chitosan (CS) polymers (AA‐g‐CS) are prepared by a one‐pot method, employing EDC/NHS as coupling agent. Then AA‐g‐CS glycerol phosphate hydrogels (AA‐g‐CS/GP hydrogel) physical cross‐linking method. The AA‐g‐CS/GP hydrogel has dense 3D network structure, which facilitates the loading of drugs. pore size wall affected amino types (Lys, Glu Gln). Berberine hydrochloride (BBH) is encapsulated in three‐dimensional structure hydrogel. Escherichia coli (Gram‐negative bacteria, E. ) Staphylococcus aureus (Gram‐positive S. selected model antibacterial properties BBH@AA‐g‐CS/GP investigated AGAR drilling method turbidimetric results show that better inhibition effect on than . can achieve long‐term within 24 h. Therefore, an excellent carrier for BBH expected to be applied extensively wound healing, tissue regeneration, cell culture.

Язык: Английский

A gelatin-chitosan-based film containing berberine hydrochloride/polypyrrole that promotes infectious wound healing through antibacterial and antioxidant properties, and electrical conductivity DOI
Yiqing Chen, Yingbin Lv, Wei Su

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141228 - 141228

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

2
Chitosan dual gel-like functionalized with flavonoid extract and cinnamaldehyde oil using dual cross-linking agents: Characterization, antioxidant, and antimicrobial effects DOI Creative Commons
Mahmoud Salah,

Juanying Huang,

Chenyang Zhu

и другие.

Current Research in Food Science, Год журнала: 2024, Номер 9, С. 100826 - 100826

Опубликована: Янв. 1, 2024

This study evaluated antioxidant and antimicrobial properties of chitosan gel (Cs-gel) functionalized with cinnamaldehyde oil (CN) orange peel-derived flavonoid extract (Fs) using the ionic-gelation method. Results showed that encapsulation efficiencies CCF-9 CCN were 83.14 ± 3.34 80.56 1.17%, respectively. The interaction CN or Fs on Cs-gel indicates presence H-bonding formation, as observed by UV-vis spectroscopy, Fourier transform infrared spectrophotometry (FTIR), Raman-spectroscopy a good corroboration Surflex-dock findings. Scanning electron microscopy also integration occurred between Cs both ligands, which was further supported X-ray diffraction X-Ray photoelectron spectroscopy spectra. textural CCF-5 high hardness, chewiness, gumminess values, indicating altered microstructure Cs-gel. Chotison-functionalized based gels exhibited higher abilities against DPPH ABTS free radicals than inhibition value 29.91 1.22 93.61 2.12%

Язык: Английский

Процитировано

7
Oral Administration of Berberine Hydrochloride Based on Chitosan/Carboxymethyl-β-Cyclodextrin Hydrogel DOI Open Access
Bukatuka Futila Clemence, Lin Xiao, Guang Yang

и другие.

Polymers, Год журнала: 2024, Номер 16(16), С. 2368 - 2368

Опубликована: Авг. 21, 2024

In this study, a novel oral formulation of berberine hydrochloride (BBH) hydrogel was successfully synthesized through physical cross-linking using chitosan (CS) and carboxymethyl-β-cyclodextrin (CMCD). The characterization results confirmed the successful synthesis CS/CMCD subsequent loading BBH into composite (CS/CMCD/BBH) effectively accomplished. used as model drug resulting demonstrated sustained release profile. addition to its improved solubility characteristics, exhibited excellent antibacterial activity against common pathogens such Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Candida albicans (C. albicans). Additionally, in vitro studies indicated that not cytotoxic NIH3T3 HaCaT cells, suggesting safety for biomedical applications. This lack effects, combined with mechanical strength, improvements, properties hydrogel, positions CS/CMCD/BBH promising candidate effective delivery BBH. By addressing challenges BBH, offers viable solution administration potential applications various fields.

Язык: Английский

Процитировано

6
pH-responsive β-cyclodextrin-grafted chitosan microspheres: Dual-action smart carriers for enhanced corrosion inhibition DOI

Nannan Cui,

Zhikun Wang, Fengting Li

и другие.

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 679, С. 1181 - 1195

Опубликована: Окт. 15, 2024

Язык: Английский

Процитировано

4
High-pressure homogenization assisted pH-shifting modified soybean lipophilic protein interacting with chitosan hydrochloride: double emulsion construction, physicochemical properties, stability, and in vitro digestion analysis DOI
Yiting Gao, Le Chen, Lijia Li

и другие.

Food Hydrocolloids, Год журнала: 2024, Номер 160, С. 110834 - 110834

Опубликована: Ноя. 13, 2024

Язык: Английский

Процитировано

4
Facile fabrication of chitosan-based molecular imprinted microspheres to adsorb selectively, release and anti-bacteria for berberine DOI
Jiying Men, Ji Wang,

Zhenyan Lv

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141592 - 141592

Опубликована: Фев. 28, 2025

Язык: Английский

Процитировано

0
Traditional Chinese Medicine-Loaded Hydrogels: An Emerging Strategy for the Treatment of Bone Infections DOI Creative Commons
Xin Jin,

Yuchen Yue,

Huaanzi Hu

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 514 - 514

Опубликована: Апрель 14, 2025

Bone infection is a disease that seriously affects patients’ quality of life and physical health. Traditional treatment methods have many drawbacks. Hydrogels loaded with Chinese Medicine (TCM), as an emerging strategy, combine the advantages good biocompatibility hydrogels, adjustable drug release performance, multi-target synergistic TCM, showing great application potential. This article elaborates in detail on research progress hydrogels TCM for bone infections, including classification characteristics mechanism action preparation examples, advantages, challenges prospects faced. The aim to provide new ideas references clinical infections.

Язык: Английский

Процитировано

0
Oral natural material hydrogels: a new strategy for enhancing oral drug delivery efficiency DOI
Qiwei Yang, Xiang Xi, Han Wang

и другие.

Journal of Biomaterials Science Polymer Edition, Год журнала: 2025, Номер unknown, С. 1 - 28

Опубликована: Май 26, 2025

Oral administration, owing to its high patient compliance and favorable controllability, is widely employed in clinical settings; however, the efficacy often constrained by gastrointestinal environment's impact on bioavailability. As demand for biocompatibility biodegradability biomedical applications intensifies, natural hydrogel-based oral drug delivery systems have gained substantial attention as promising carriers. In this study, we introduce a variety of materials, revealing their advantages enhancing bioavailability targeting capabilities. Through both physical chemical crosslinking mechanisms, successfully demonstrate hydrogels exhibiting excellent mechanical properties biocompatibility. Furthermore, analyze potential diverse across fields such gastrointestinal, metabolic, oncological, immunotherapeutic diseases. By synthesizing recent advances area, aim elucidate critical role these can play biomedicine. Our findings suggest that materials possess broad prospects delivery, advocating continued exploration application facilitate development optimization novel therapeutic modalities. This work provides vital theoretical foundation practical guidance future innovations technologies.

Язык: Английский

Процитировано

0
Oral Administration of Berberine Hydrochloride Based on Chitosan/Carboxymethyl-β-Cyclodextrin Hydrogel DOI Open Access
Bukatuka Futila Clemence, Lin Xiao, Guang Yang

и другие.

Опубликована: Июль 22, 2024

In this study, a novel oral formulation of berberine hydrochloride (BBH) hydrogel was successfully synthesized through physical cross-linking using chitosan (CS) and carboxymethyl-β-cyclodextrin (CMCD). The characterization results confirmed the successful synthesis CS/CMCD subsequent loading BBH into composite (CS/CMCD/BBH) effectively accomplished. used as model drug resulting demonstrated sustained release profile. addition to its improved solubility characteristics, exhibited excellent antibacterial activity against common pathogens such Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Candida albicans (C. albicans). Additionally, in vitro studies indicated that not cytotoxic NIH3T3 HaCaT cells, suggesting safety for biomedical applications. This lack effects, combined with mechanical strength, improvements, properties hydrogel, positions CS/CMCD/BBH promising candidate effective delivery BBH. By addressing challenges BBH, offers viable solution administration hydrochloride, potential applications various fields.

Язык: Английский

Процитировано

2
Inclusion Complex of Berberine Hydrochloride with Serine-β-cyclodextrin: Construction, Characterization, Inclusion mechanism, and Bioactivity DOI

Dong Ju Zhou,

Weiming Liu,

Su Ping Dai

и другие.

New Journal of Chemistry, Год журнала: 2024, Номер 48(36), С. 15884 - 15893

Опубликована: Янв. 1, 2024

Ser-β-CD was synthesized and a BBH/Ser-β-CD IC prepared via the freeze-drying method. show good biocompatibility. The exhibits sustained BBH release efficiency excellent antibacterial activity against E. coli S. aureus .

Язык: Английский

Процитировано

2