Synthesis and Anti-Biofilm Activity Studies on Novel Quinazolinone-Thiadiazole Hybrids

Clinical and Experimental Health Sciences, Год журнала: 2025, Номер 15(1), С. 170 - 174

Опубликована: Март 23, 2025

Objective: In this study it was aimed to synthesize novel 1,3,4-thiadizole bearing 4(3H)-quinazolinone compounds, elucidate their structure and evaluate anti-biofilm activity. Methods: Four compounds (1-4) were synthesized with a two step reaction starting from 5-bromoanthranilic acid. Their activity investigated. Results: The final compounds’ structures clarified by elemental analysis spectroscopic methods (IR, 1H-NMR, 13C-NMR MS). the result of studies, they possessed 26.0-30.0% biofilm formation inhibition. Conclusion: Among tested 6-bromo-3-{4-[5-(4-nitrophenylamino)-1,3,4-thiadiazol-2-yl]phenyl}-2-methylquinazolin-4(3H)-one formulated compound 3 found as most active one 30.0%

Язык: Английский

Deciphering the complex landscape of post-translational modifications on PKM2: Implications in head and neck cancer pathogenesis

Life Sciences, Год журнала: 2024, Номер 349, С. 122719 - 122719

Опубликована: Май 15, 2024

Язык: Английский

Inhibiting brushite crystal growth: molecular docking exploration of Enhydra fluctuans phytoconstituents and their interaction with human serum albumin

Journal of Biomolecular Structure and Dynamics, Год журнала: 2024, Номер unknown, С. 1 - 10

Опубликована: Дек. 20, 2024

In our preliminary

Язык: Английский