A copper(II) aminopyrimidinone complex: X-ray crystallography, computational analysis, dielectric spectroscopy and molecular docking DOI

Wijdène Nbili,

Sofian Gatfaoui,

Hassen Dhaouadi

и другие.

Journal of Coordination Chemistry, Год журнала: 2024, Номер 77(5-6), С. 525 - 542

Опубликована: Март 3, 2024

A new copper(II) complex with 2-amino-6-methylpyrimidin-4-(1H)-one, [Cu(C5H7N3O)4](NO3)2·H2O (Cupyrim), has been synthesized and studied by X-ray diffraction, elemental analysis FT-IR spectroscopy. The Cu(II) is four-coordinate in a square planar geometry four nitrogen atoms of the organic ligands. Hirshfeld Surface Analysis was conducted to understand crystalline packing. Overall, structure maintained metal coordination as well strong weak (C,N)–H···O hydrogen bonds C–H…π interactions. IR spectrum primary peaks have assigned vibration modes ligand functional groups. An investigation inhibitory properties Cupyrim toward "Cyclin-dependent Kinase 2" (CdK2) "inducible nitric oxide synthase" (iNOS) proteins aided molecular docking research. According docking, exhibits promising efficacy against Parkinson's, schizophrenia, Alzheimer's disorders. temperature dependence real imaginary part dielectric permittivity analyzed Cole-Cole formalism DSC diagrams from 45-147 °C.

Язык: Английский

Quantum computational investigation into the optoelectronic and NLO properties of C8H8O3.C3H7NO2 single crystal DOI
P. Jayaprakash, R. Ramachandran, S. Selvaraj

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер 1319, С. 139488 - 139488

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2

Elucidation of Structure, Spectroscopic Investigation, and Computational Studies of a New Zn(II) Complex with a Theophylline-Based Ligand: Insights from XRD, IR, UV, PL, DFT, and Molecular Docking DOI

Wijdène Nbili,

Sibel Demi̇r Kanmazalp, Yusuf Sert

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141673 - 141673

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

A neutral 1D polymeric Hg(II) complex harvested from 9-butyl adenine: Synthesis, Crystal structure, Hirshfeld surface, DFT optimization, and Anti-microbial activities DOI

Tirtha Bhattacharjee,

Sourav Nath,

Tanushree Sen

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142389 - 142389

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Supramolecular Co (II) Complex Fabricated From Adenine Derivative: Synthesis, Crystal Structure, Hirshfeld Surface, DFT Optimization, Anticancer, and Molecular Docking Studies DOI Open Access
Sourav Debnath, Tanushree Sen, Sourav Roy

и другие.

Applied Organometallic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

ABSTRACT This article presents the synthesis of a novel mononuclear Co (II) complex [ Co(9‐BuA) 2 Cl ] (1) , its characterization, supramolecular packing pattern, theoretical calculations, anticancer properties, and molecular docking studies. Complex 1 was generated from 9‐butyl adenine ( 9‐BuA ) building block characterized by spectroscopic methods (FT‐IR, mass, elemental analysis) single crystal X‐ray diffraction analysis. The cobalt ion in is distorted tetrahedral environment. +2 coordinated to two rare N1 binding sites pyrimidinate moiety ligands chlorine atoms occupying axial positions. Both intramolecular intermolecular hydrogen bonds support formation assembly stabilize structure. nature interactions network also decoded Hirshfeld surface analysis contours d norm ). percentage contributions are represented 2D fingerprint plots. average energy between dimers determined framework analysis, packing's three‐dimensional topology investigated. Density functional theory (DFT) has been used ascertain geometry complex. cytotoxic effects corresponding ligand were investigated Dalton's lymphoma (DL) malignant cancer cells on normal peripheral blood (PBMCs) evaluate their activity. Finally, analyses have carried out analyze receptor.

Язык: Английский

Процитировано

1

A copper(II) aminopyrimidinone complex: X-ray crystallography, computational analysis, dielectric spectroscopy and molecular docking DOI

Wijdène Nbili,

Sofian Gatfaoui,

Hassen Dhaouadi

и другие.

Journal of Coordination Chemistry, Год журнала: 2024, Номер 77(5-6), С. 525 - 542

Опубликована: Март 3, 2024

A new copper(II) complex with 2-amino-6-methylpyrimidin-4-(1H)-one, [Cu(C5H7N3O)4](NO3)2·H2O (Cupyrim), has been synthesized and studied by X-ray diffraction, elemental analysis FT-IR spectroscopy. The Cu(II) is four-coordinate in a square planar geometry four nitrogen atoms of the organic ligands. Hirshfeld Surface Analysis was conducted to understand crystalline packing. Overall, structure maintained metal coordination as well strong weak (C,N)–H···O hydrogen bonds C–H…π interactions. IR spectrum primary peaks have assigned vibration modes ligand functional groups. An investigation inhibitory properties Cupyrim toward "Cyclin-dependent Kinase 2" (CdK2) "inducible nitric oxide synthase" (iNOS) proteins aided molecular docking research. According docking, exhibits promising efficacy against Parkinson's, schizophrenia, Alzheimer's disorders. temperature dependence real imaginary part dielectric permittivity analyzed Cole-Cole formalism DSC diagrams from 45-147 °C.

Язык: Английский

Процитировано

0