Synthesis, Physicochemical Properties, and Ion Recognition Ability of Azulene-Based Bis-(Thio)Semicarbazone DOI Creative Commons
Anamaria Hanganu, Cătălin Maxim, Andreea Dogaru

и другие.

Molecules, Год журнала: 2024, Номер 30(1), С. 83 - 83

Опубликована: Дек. 29, 2024

Azulene-1,3-bis(semicarbazone), 1, and azulene-1,3-bis(thiosemicarbazone), 2, were synthesized by the acid-catalyzed condensation reactions of semicarbazide thiosemicarbazide, respectively, with azulene-1,3-dicarboxaldehyde in stoichiometric amounts. Compounds 1 2 identified high-resolution mass spectrometry characterized IR, 1H-NMR, 13C-NMR, UV-vis spectroscopic techniques. Crystal structure determination azulene-1,3-bis(thiosemicarbazone) shows that thiosemicarbazone units exhibit a syn-closed conformation, both arms oriented same direction adopting an E configuration respect to imine linkages. Both hydrazones are redox active showed fluorescence emission at 450 nm upon excitation 350 nm. The bis-semicarbazone no affinity for anions nor mercury(II) metal cation. Instead, bis-thiosemicarbazone lower chloride anions, but enhanced binding/poisoning Hg2+ ions. compounds tested against osteosarcoma MG63 cell lines, exhibiting low antiproliferative activity comparable IC50 values 473.08 μM 472.40 respectively. Despite this limited effect, further analysis using propidium iodide staining revealed concentration-dependent decrease viability, high concentrations inducing marked reduction number, accompanied morphological changes characteristic apoptosis necrosis.

Язык: Английский

Sonosynthesis of new functionalized optically active triazines via double Mannich reaction: antibacterial potential and in silico docking study DOI Creative Commons
Hajar A. Ali, Mohamed M. Hammouda, Mohamed A. Ismail

и другие.

RSC Advances, Год журнала: 2025, Номер 15(22), С. 17516 - 17534

Опубликована: Янв. 1, 2025

In this study, we employed both conventional and ultrasound irradiation approaches to fabricate a library of ten new triazine hybrids by the divergent double-Mannich reaction.

Язык: Английский

Процитировано

0
Synthesis, characterization, quantum mechanical calculations and biomedical docking studies on Curcumin analogues: 2, 6-(Difurfurylidene) cyclohexanone and 2, 6 – Bis (2,6-Dichloro Benzylidene) Cyclohexanone DOI Creative Commons

S. Sathiyamoorthi,

C. Meganathan,

K Thiruppathi

и другие.

Heliyon, Год журнала: 2024, Номер 10(19), С. e38300 - e38300

Опубликована: Сен. 27, 2024

Язык: Английский

Процитировано

0
Synthesis, Physicochemical Properties, and Ion Recognition Ability of Azulene-Based Bis-(Thio)Semicarbazone DOI Creative Commons
Anamaria Hanganu, Cătălin Maxim, Andreea Dogaru

и другие.

Molecules, Год журнала: 2024, Номер 30(1), С. 83 - 83

Опубликована: Дек. 29, 2024

Azulene-1,3-bis(semicarbazone), 1, and azulene-1,3-bis(thiosemicarbazone), 2, were synthesized by the acid-catalyzed condensation reactions of semicarbazide thiosemicarbazide, respectively, with azulene-1,3-dicarboxaldehyde in stoichiometric amounts. Compounds 1 2 identified high-resolution mass spectrometry characterized IR, 1H-NMR, 13C-NMR, UV-vis spectroscopic techniques. Crystal structure determination azulene-1,3-bis(thiosemicarbazone) shows that thiosemicarbazone units exhibit a syn-closed conformation, both arms oriented same direction adopting an E configuration respect to imine linkages. Both hydrazones are redox active showed fluorescence emission at 450 nm upon excitation 350 nm. The bis-semicarbazone no affinity for anions nor mercury(II) metal cation. Instead, bis-thiosemicarbazone lower chloride anions, but enhanced binding/poisoning Hg2+ ions. compounds tested against osteosarcoma MG63 cell lines, exhibiting low antiproliferative activity comparable IC50 values 473.08 μM 472.40 respectively. Despite this limited effect, further analysis using propidium iodide staining revealed concentration-dependent decrease viability, high concentrations inducing marked reduction number, accompanied morphological changes characteristic apoptosis necrosis.

Язык: Английский

Процитировано

0