Journal of Medicinal and Chemical Sciences,
Год журнала:
2024,
Номер
7(7)
Опубликована: Июль 1, 2024
This
study
is
aimed
at
the
preparation
and
characterization
of
coumarin
derivative,
4-((5-amino-1,
3,
4-thiadiazol-2-yl)
methoxy)
(ATMC)
determination
antitumor
activity
compound.
The
compound
was
prepared
through
a
synthetic
route
starting
with
4–hydroxycoumarin
by
undergoing
sequence
chemical
reactions.
confirmation
ATMC
structure
done
different
spectroscopy
methods
such
as
FT-IR,
1H-NMR,
13C-NMR,
also
further
analysis.
In
biological
profiling
experiment,
antibacterial
activity,
antifungal
antioxidant
were
examined.
in
vitro
efficacy
antimicrobial
shown
zone
inhibitory
which
ranged
15
to
22
mm
against
Escherichia
coli,
Pseudomonas
aeruginosa,
Klebsiella
pneumoniae,
Proteus
vulgaris,
Staphylococcus
aureus.
addition
this
shows
that
has
strong
inhibition
Aspergillus
niger
Candida
alb.
Based
on
provided
data,
it
can
be
suggested
possesses
various
effects,
de-monstrates
prospect
its
application
therapeutic
drug.
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(6)
Опубликована: Апрель 8, 2024
Plant-derived
coumarin
(PDC)
is
a
naturally
occurring
heterocyclic
backbone
that
belongs
to
the
benzopyrone
family.
PDC
and
its
based
products
are
characterized
by
low
toxicity
high
distribution
in
variety
of
herbal
treatments
have
numerous
therapeutic
potentials.
These
include
anticoagulants,
antibacterials,
anti-inflammatory
agents,
anticancer
antioxidants,
others.
So,
it
may
be
appropriate
investigate
qualities
potential
bioactivities
PDCs.
This
article
provides
an
overview
biomedical
potentials,
availability,
clinical
use
possibilities
PDCs,
with
focus
on
their
important
modes
action,
using
information
various
pharmacological
discovered.
The
data
used
this
study
came
from
published
research
between
2015
2023.
We
reviewed
selection
databases,
including
PubMed,
Scopus,
Web
Science,
Google
Scholar,
during
period.
In
conclusion,
because
abundance
medicinal
plants,
biochemistry
attributes
PDCs
currently
interest.
medical
specialties,
serve
useful
role
as
agents.
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(6)
Опубликована: Апрель 15, 2024
For
the
first
time,
kinetic
thermomagnetic
extraction
is
a
novel
approach
presented
in
this
work.
It
required
application
of
four
distinct
variables:
rotation
speed
(50,
75,
and
100
rpm),
magnetic
field
(0.8,
1.2,
1.6
T),
time
interval
(30,
60,
90
min),
temperature
(45,
55,
65
°C).
Numerous
phytochemical
categories
were
detected
81
crude
chloroform
extracts
green
sweet
bell
pepper
seeds
that
collected,
according
to
analysis.
Nine
discovered
be
linked
coumarin
chemical
class
have
same
two
parameters:
90-minute
duration
55
°C
temperature.
To
enable
their
contents
chemically
separated
chromatographically
purified,
these
containing
chosen.
Four
new
phytocoumarins
been
identified
molecular
structures
distinguished
using
FTIR
spectra,
Results in Chemistry,
Год журнала:
2024,
Номер
8, С. 101611 - 101611
Опубликована: Июнь 1, 2024
Despite
the
up-to-date
advancements
in
its
treatment,
cancer
is
still
being
harvested
lives
of
millions
people
annually;
this
health
threat
necessitates
exploring
more
potent
agents
that
can
effectively
fight
it.
The
class
heterocycles
known
as
coumarin,
and
natural
synthetic
derivatives
are
thought
to
be
biomedically
valuable.
Coumarins
have
low
side
effects,
outstanding
selectivity,
a
straightforward
design
for
maximum
efficiency,
various
pharmacological
actions.
For
these
characteristics,
coumarins
continuously
isolated
from
sources
synthesized
laboratories,
alongside
with
examining
them
possible
bioactivities.
In
addition
garnering
significant
attention,
coumarin
has
emerged
valuable
scaffold
potentially
important
precursor
development
innovative
anticancer
medicines.
Researchers
working
create
new
cancer-fighting
coumarins,
well
investigating
old
ones.
Integration
two
or
cyclic
moieties
into
single
molecular
framework
might
enhance
existing
effects
perhaps
provide
entirely
Numerous
studies
shown
synergistic
additive
impact
when
fused
where
fusion
may
occur
at
coumarin-benzene
coumarin-lactone.
current
paper
explores
detail
how
linearly
ring-fused
combat
cancer.
derivative
number
42
was
determined
best
among
were
reviewed.
Compared
5-flourouracil,
IC50
values
against
six
cell
lines
promising.
These
25.08,
13.42,
41.45,
28.43,
31.15,
13.08
μM
SK-OV-3,
HeLa,
KYSE-30,
AMN3,
SKG,
MCF-7,
respectively.
attribute
obvious
compared
those
reference,
which
following
same
order
lines:
22.43,
13.37,
30.72,
24.89,
22.12,
12.42
μM.
researchers
conducted
searches
across
multiple
data
repositories,
such
Scopus,
Google
Scholar,
Web
Science,
PubMed.
After
conducting
thorough
analysis,
authors
found
included
59
pertinent
publications
published
by
end
2023.
reviewed
help
medicinal
chemists
manufacture
functionally
active
leads
using
scaffolds
been
mentioned.
knowledge
derived
offer
substantial
medical
benefits
short
term
powerful
drugs
could
boost
chemotherapeutics.
