Analytical Methods,
Год журнала:
2024,
Номер
16(25), С. 4024 - 4040
Опубликована: Янв. 1, 2024
Environmental
pollutants
like
chlorophenol
chemicals
and
their
derivatives
are
commonplace.
These
compounds
serve
as
building
blocks
in
the
production
of
medicines,
biocides,
dyes,
agricultural
chemicals.
Chlorophenols
enter
environment
through
several
different
pathways,
including
breakdown
complex
chlorinated
hydrocarbons,
industrial
waste,
herbicides,
insecticides.
destroyed
thermally
chemically,
creating
dangerous
that
pose
a
threat
to
public
health.
Water
particular
is
affected,
thorough
monitoring
required
find
this
source
pollution
because
it
can
major
hazard
both
human
environmental
For
detection
chlorophenols,
molecularly
imprinted
polymers
(MIPs)
have
been
incorporated
into
variety
electrochemical
sensing
systems
assay
formats.
Due
long-term
chemical
physical
stability
well
simple
affordable
synthesis
process,
MIPs
become
intriguing
synthetic
alternatives
over
past
few
decades.
In
review,
we
concentrate
on
commercial
potential
MIP
technology.
Additionally,
want
outline
most
recent
advancements
incorporation
sensors
with
high
for
detecting
chlorophenols.
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(6)
Опубликована: Апрель 8, 2024
Plant-derived
coumarin
(PDC)
is
a
naturally
occurring
heterocyclic
backbone
that
belongs
to
the
benzopyrone
family.
PDC
and
its
based
products
are
characterized
by
low
toxicity
high
distribution
in
variety
of
herbal
treatments
have
numerous
therapeutic
potentials.
These
include
anticoagulants,
antibacterials,
anti-inflammatory
agents,
anticancer
antioxidants,
others.
So,
it
may
be
appropriate
investigate
qualities
potential
bioactivities
PDCs.
This
article
provides
an
overview
biomedical
potentials,
availability,
clinical
use
possibilities
PDCs,
with
focus
on
their
important
modes
action,
using
information
various
pharmacological
discovered.
The
data
used
this
study
came
from
published
research
between
2015
2023.
We
reviewed
selection
databases,
including
PubMed,
Scopus,
Web
Science,
Google
Scholar,
during
period.
In
conclusion,
because
abundance
medicinal
plants,
biochemistry
attributes
PDCs
currently
interest.
medical
specialties,
serve
useful
role
as
agents.
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(6)
Опубликована: Апрель 15, 2024
For
the
first
time,
kinetic
thermomagnetic
extraction
is
a
novel
approach
presented
in
this
work.
It
required
application
of
four
distinct
variables:
rotation
speed
(50,
75,
and
100
rpm),
magnetic
field
(0.8,
1.2,
1.6
T),
time
interval
(30,
60,
90
min),
temperature
(45,
55,
65
°C).
Numerous
phytochemical
categories
were
detected
81
crude
chloroform
extracts
green
sweet
bell
pepper
seeds
that
collected,
according
to
analysis.
Nine
discovered
be
linked
coumarin
chemical
class
have
same
two
parameters:
90-minute
duration
55
°C
temperature.
To
enable
their
contents
chemically
separated
chromatographically
purified,
these
containing
chosen.
Four
new
phytocoumarins
been
identified
molecular
structures
distinguished
using
FTIR
spectra,
Results in Chemistry,
Год журнала:
2024,
Номер
8, С. 101611 - 101611
Опубликована: Июнь 1, 2024
Despite
the
up-to-date
advancements
in
its
treatment,
cancer
is
still
being
harvested
lives
of
millions
people
annually;
this
health
threat
necessitates
exploring
more
potent
agents
that
can
effectively
fight
it.
The
class
heterocycles
known
as
coumarin,
and
natural
synthetic
derivatives
are
thought
to
be
biomedically
valuable.
Coumarins
have
low
side
effects,
outstanding
selectivity,
a
straightforward
design
for
maximum
efficiency,
various
pharmacological
actions.
For
these
characteristics,
coumarins
continuously
isolated
from
sources
synthesized
laboratories,
alongside
with
examining
them
possible
bioactivities.
In
addition
garnering
significant
attention,
coumarin
has
emerged
valuable
scaffold
potentially
important
precursor
development
innovative
anticancer
medicines.
Researchers
working
create
new
cancer-fighting
coumarins,
well
investigating
old
ones.
Integration
two
or
cyclic
moieties
into
single
molecular
framework
might
enhance
existing
effects
perhaps
provide
entirely
Numerous
studies
shown
synergistic
additive
impact
when
fused
where
fusion
may
occur
at
coumarin-benzene
coumarin-lactone.
current
paper
explores
detail
how
linearly
ring-fused
combat
cancer.
derivative
number
42
was
determined
best
among
were
reviewed.
Compared
5-flourouracil,
IC50
values
against
six
cell
lines
promising.
These
25.08,
13.42,
41.45,
28.43,
31.15,
13.08
μM
SK-OV-3,
HeLa,
KYSE-30,
AMN3,
SKG,
MCF-7,
respectively.
attribute
obvious
compared
those
reference,
which
following
same
order
lines:
22.43,
13.37,
30.72,
24.89,
22.12,
12.42
μM.
researchers
conducted
searches
across
multiple
data
repositories,
such
Scopus,
Google
Scholar,
Web
Science,
PubMed.
After
conducting
thorough
analysis,
authors
found
included
59
pertinent
publications
published
by
end
2023.
reviewed
help
medicinal
chemists
manufacture
functionally
active
leads
using
scaffolds
been
mentioned.
knowledge
derived
offer
substantial
medical
benefits
short
term
powerful
drugs
could
boost
chemotherapeutics.
RSC Advances,
Год журнала:
2024,
Номер
14(28), С. 20163 - 20181
Опубликована: Янв. 1, 2024
Because
of
the
serious
risks
they
pose
to
environment
and
public
health,
chlorophenols
(CPs),
a
typical
class
most
persistent
organic
pollutants,
have
drawn
increasing
attention.
Monitoring
CPs
effectively
has
become
pressing
difficult
problem.
The
rapidly
need
for
onsite
real-time
CP
detection
led
consideration
electrochemical
sensing
as
workable
solution.
Molecularly
imprinted
polymer
(MIP)-based
emerged
promising
area
environmental
monitoring
in
response
this
analytical
MIPs,
conjunction
with
miniature
transducers,
provide
opportunity
detect
target
analytes
situ.
These
devices
advantages
great
chemical
physical
stability,
cheap
production
costs,
good
selectivity,
quick
times.
Most
studies
suggest
that
these
sensors
use
nanoparticles
improve
their
properties,
especially
sensitivity.
Furthermore,
successfully
used
real
water
samples
without
time-consuming
pretreatment
procedures.
This
article
provides
an
overview
MIP-based
reported
samples.
To
obtain
highest
sensitivity,
special
is
given
fabrication
sensors,
which
includes
various
functional
monomers,
platforms,
materials.
Several
other
parameters
are
also
discussed,
including
linear
concentration
range,
limit
detection,
types
were
examined.
