Photoresponsive Nitric Oxide Release from Aggregation-Induced Emission-Based Ruthenium–Nitrosyl Complexes and Their Anticancer Activity through In Situ Formation of Peroxynitrite DOI

Nitin Nitin,

Kanika Kaushal,

Tanu Singh

и другие.

Inorganic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Nitric oxide (NO) is recognized as a gaseous chemical mediator that regulates various physiological functions. Two naphthalene-appended terpyridine-based mononuclear ruthenium-nitrosyl complexes with the molecular framework [1.Ru2+(L)NO](PF6)3 (L = 2,2'-bipyridine (bpy) or phenanthroline (phen) and 1 4'-(anthracene-9-yl)-2,2':6',2″-terpyridine), named 1.Ru(bpy)NO 1.Ru(phen)NO, were reported for NO delivery. The introduction of ancillary ligands (bpy phen) to Ru-center led noticeable variations photophysical properties aggregation behavior in aqueous solution, which helps modulate release. Both facilitate photocleavage Ru-NO bond on exposure either blue (410 nm) green light (525 CH3CN CH3CN-H2O (20/80, v/v) mixture. photo release kinetics 1.Ru(phen)NO have been studied detail confirmed by IR studies, Griess assay, DAF assay. interaction photoinduced singlet oxygen (1O2) thereby formation peroxynitrite (ONOO-) emission cytotoxicity MTT assay these human neuroblastoma cancerous cells without irradiation was also investigated. Notably, situ ONOO- produces potent anticancer effects originated from 1O2 an solution.

Язык: Английский

Photoresponsive Nitric Oxide Release from Aggregation-Induced Emission-Based Ruthenium–Nitrosyl Complexes and Their Anticancer Activity through In Situ Formation of Peroxynitrite DOI

Nitin Nitin,

Kanika Kaushal,

Tanu Singh

и другие.

Inorganic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Nitric oxide (NO) is recognized as a gaseous chemical mediator that regulates various physiological functions. Two naphthalene-appended terpyridine-based mononuclear ruthenium-nitrosyl complexes with the molecular framework [1.Ru2+(L)NO](PF6)3 (L = 2,2'-bipyridine (bpy) or phenanthroline (phen) and 1 4'-(anthracene-9-yl)-2,2':6',2″-terpyridine), named 1.Ru(bpy)NO 1.Ru(phen)NO, were reported for NO delivery. The introduction of ancillary ligands (bpy phen) to Ru-center led noticeable variations photophysical properties aggregation behavior in aqueous solution, which helps modulate release. Both facilitate photocleavage Ru-NO bond on exposure either blue (410 nm) green light (525 CH3CN CH3CN-H2O (20/80, v/v) mixture. photo release kinetics 1.Ru(phen)NO have been studied detail confirmed by IR studies, Griess assay, DAF assay. interaction photoinduced singlet oxygen (1O2) thereby formation peroxynitrite (ONOO-) emission cytotoxicity MTT assay these human neuroblastoma cancerous cells without irradiation was also investigated. Notably, situ ONOO- produces potent anticancer effects originated from 1O2 an solution.

Язык: Английский

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