Repurposing FDA-approved drugs targeting FZD10 in nasopharyngeal carcinoma: insights from molecular dynamics simulations and experimental validation DOI Creative Commons
Chawalit Ngernsombat, Utid Suriya,

Pongphol Prattapong

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 28, 2024

Wnt signaling is a critical pathway implicated in cancer development, with Frizzled proteins, particularly FZD10, playing key roles tumorigenesis and recurrence. This study focuses on the potential of repurposed FDA-approved drugs targeting FZD10 as therapeutic strategy for nasopharyngeal carcinoma (NPC). The tertiary structure human was constructed using homology modeling, validated by Ramachandran plot ProQ analysis. Virtual screening 1,094 identified 17 inhibitors, prazosin, rilpivirine, doxazosin, nicergoline demonstrating significant cytotoxicity against NPC cells. Further molecular dynamics simulations binding energy analyses confirmed stable these to FZD10. results suggest that could serve promising candidates targeted therapy, warranting further investigation.

Язык: Английский

Synthesis, characterization and sensor applications of a new 1,4-naphthoquinone derivative molecule DOI
Oğuz Özbek, Onur Cem Altunoluk, Kıymet Berkil Akar

и другие.

Chemical Papers, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Язык: Английский

Процитировано

1
Maeruines A−E, elusive indole alkaloids from stems of Maerua siamensis and their inhibitory effects on cyclooxygenases and HT-29 colorectal cancer cell proliferation DOI

Sasiwimon Nukulkit,

Nonthaneth Nalinratana, Thammarat Aree

и другие.

Phytochemistry, Год журнала: 2024, Номер 229, С. 114291 - 114291

Опубликована: Сен. 24, 2024

Язык: Английский

Процитировано

1
Repurposing FDA-approved drugs targeting FZD10 in nasopharyngeal carcinoma: insights from molecular dynamics simulations and experimental validation DOI Creative Commons
Chawalit Ngernsombat, Utid Suriya,

Pongphol Prattapong

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 28, 2024

Wnt signaling is a critical pathway implicated in cancer development, with Frizzled proteins, particularly FZD10, playing key roles tumorigenesis and recurrence. This study focuses on the potential of repurposed FDA-approved drugs targeting FZD10 as therapeutic strategy for nasopharyngeal carcinoma (NPC). The tertiary structure human was constructed using homology modeling, validated by Ramachandran plot ProQ analysis. Virtual screening 1,094 identified 17 inhibitors, prazosin, rilpivirine, doxazosin, nicergoline demonstrating significant cytotoxicity against NPC cells. Further molecular dynamics simulations binding energy analyses confirmed stable these to FZD10. results suggest that could serve promising candidates targeted therapy, warranting further investigation.

Язык: Английский

Процитировано

0