Aldose reductase with quinolone antibiotics interaction: In vitro and in silico approach of its relationship with diabetic complications
Archives of Biochemistry and Biophysics,
Год журнала:
2024,
Номер
unknown, С. 110161 - 110161
Опубликована: Сен. 1, 2024
Язык: Английский
Avicularin is a minor aldose reductase inhibitor in defatted seeds of Oenothera biennis L.: Screening, inhibitory kinetics, and interaction mechanism
Food Chemistry,
Год журнала:
2025,
Номер
473, С. 143100 - 143100
Опубликована: Янв. 31, 2025
Язык: Английский
Discovery of Hydrazine Clubbed Thiazoles as Potential Antidiabetic Agents: Synthesis, Biological Evaluation, and Molecular Docking Studies
Drug Development Research,
Год журнала:
2025,
Номер
86(1)
Опубликована: Фев. 1, 2025
ABSTRACT
In
this
study,
hydrazine
clubbed
thiazole
derivatives
(
3a
–
3j
)
were
obtained
by
Hantzsch
synthesis
and
characterized
MS,
1
H
NMR,
13
C
NMR.
The
inhibitory
potentials
of
the
against
diabetes‐related
enzymes
such
as
aldose
reductase
(AR),
α‐glycosidase
(α‐GLY),
α‐amylase
(α‐AMY)
experimentally
determined,
results
supported
molecular
docking.
showed
that
displayed
varied
degree
potential
activity,
with
K
I
values
covering
following
ranges:
5.47
±
0.53
to
23.89
1.46
nM
for
AR
1.76
0.01
24.81
0.15
μM
α‐GLY,
IC
50
4.94–28.17
α‐AMY,
compared
standard
epalrestat
acarbose
:
34.53
2.52
23.53
2.72
respectively).
selective
activity
these
on
antidiabetic
may
be
important
treatment
diabetes
lead
development
alternative
new
compounds
purpose.
Язык: Английский
Identification of aldose reductase inhibitors from the flowers of Tussilago farfara using PCN-222 metal-organic framework-based immobilization-free affinity selection coupled with high-performance liquid chromatography
Journal of Chromatography A,
Год журнала:
2025,
Номер
1748, С. 465879 - 465879
Опубликована: Март 15, 2025
Язык: Английский