Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 25, 2024

This study involved synthesis of a novel antibacterial heterocyclic compound, sodium 2-(2-(3-phenyl-1, 2, 4-oxadiazol-5-yl) phenoxy) acetate abbreviated as Na-POPA. Further development biocompatible, pH-responsive hydrogel drug carrier prepared utilizing the natural polymers gelatin and alginate. The compound loaded on represented new delivery system. Comprehensive characterization Na-POPA was performed using Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (¹H NMR), carbon-13 (¹³C high-resolution mass spectrometry (HRMS). onto alginate/gelatin under feasible experimental conditions. successful incorporation into matrix confirmed via scanning electron microscopy (SEM), powder X-ray diffraction (pXRD) analysis FT-IR spectroscopy. Cytotoxicity assays revealed that all unloaded induced cell toxicity at large concentration much lower than many reported results. reduced inherent cytotoxicity enhanced its biocompatibility. release kinetics from were evaluated spectrophotometrically different pH conditions simulating biological fluids. rate 1.2 greater 6.8, with higher cumulative observed 6.8. obeyed pseudo-second-order kinetic model, indicating controlled mechanism influenced by hydrogel's physicochemical properties. Electrochemical impedance cyclic voltammetry further pH-dependent. high swelling solubility 6.8 enhance release. larger amount released (target intestine) because more solubility, leaching rather shrinking.

Язык: Английский