A novel water-soluble dinuclear Pd(II) complex having 4,4′- bipyridine and diethylenetriamine ligands and its interaction with DNA and BSA DOI

Narjes Alisufi,

Effat Dehghanian, Hassan Mansouri‐Torshizi

и другие.

Journal of Biomolecular Structure and Dynamics, Год журнала: 2025, Номер unknown, С. 1 - 16

Опубликована: Март 7, 2025

A novel dinuclear palladium(II) complex i.e., [{Pd(dien)}2(µ-4,4′-bpy)]Cl4, (dien = diethylenetriamine and bpy bipyridine), has been synthesized characterized by means of conductivity measurement, elemental analysis, FT-IR, 1D 1H NMR, 2D NMR 13C NMR. Binding characteristics this to DNA BSA was investigated electronic absorption, fluorescence, electrophoresis, energy transfer, circular dichroism cyclic voltammetry which revealed that van der Waals hydrogen bonds are the main binding forces for di-Pd(II) interaction with mentioned biomacromolecules. The cytotoxicity assay performed on human acute lymphoblastic leukemia (MOLT-4) cell line. Finally, identify DNA/BSA site metal complex, theoretical investigations were conducted utilizing molecular docking.

Язык: Английский

A novel water-soluble dinuclear Pd(II) complex having 4,4′- bipyridine and diethylenetriamine ligands and its interaction with DNA and BSA DOI

Narjes Alisufi,

Effat Dehghanian, Hassan Mansouri‐Torshizi

и другие.

Journal of Biomolecular Structure and Dynamics, Год журнала: 2025, Номер unknown, С. 1 - 16

Опубликована: Март 7, 2025

A novel dinuclear palladium(II) complex i.e., [{Pd(dien)}2(µ-4,4′-bpy)]Cl4, (dien = diethylenetriamine and bpy bipyridine), has been synthesized characterized by means of conductivity measurement, elemental analysis, FT-IR, 1D 1H NMR, 2D NMR 13C NMR. Binding characteristics this to DNA BSA was investigated electronic absorption, fluorescence, electrophoresis, energy transfer, circular dichroism cyclic voltammetry which revealed that van der Waals hydrogen bonds are the main binding forces for di-Pd(II) interaction with mentioned biomacromolecules. The cytotoxicity assay performed on human acute lymphoblastic leukemia (MOLT-4) cell line. Finally, identify DNA/BSA site metal complex, theoretical investigations were conducted utilizing molecular docking.

Язык: Английский

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