Benzothiazole a privileged scaffold for Cutting-Edges anticancer agents: Exploring drug design, structure-activity relationship, and docking studies
European Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
279, С. 116831 - 116831
Опубликована: Сен. 6, 2024
Язык: Английский
Discovery of novel 2,6-disubstituted-3-cyano-4-(trifluoromethyl)pyridine derivatives as potential anti‑prostate cancer agents targeting BLM helicase
Journal of Molecular Structure,
Год журнала:
2025,
Номер
unknown, С. 142837 - 142837
Опубликована: Май 1, 2025
Язык: Английский
Chalcone derivatives containing 1,2,4-triazole and pyridine moiety: design, synthesis, and antiviral activity
Hui Xin,
Jiao Tian,
Tianyu Deng
и другие.
Molecular Diversity,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 2, 2024
Язык: Английский
Anticancer Effect of Novel Phthalazines Derivatives: Synthesis, Biological Evaluation, DFT, ADMET and Docking Study
Journal of Molecular Structure,
Год журнала:
2024,
Номер
unknown, С. 141173 - 141173
Опубликована: Дек. 1, 2024
Язык: Английский
Cost‐effective synthesis of unsymmetric tetrazines
Bulletin of the Korean Chemical Society,
Год журнала:
2024,
Номер
45(10), С. 867 - 872
Опубликована: Окт. 1, 2024
Abstract
1,2,4,5‐Tetrazines
serve
as
versatile
two‐carbon
synthons,
essential
for
synthesizing
a
variety
of
(hetero)aromatic
compounds.
Their
specific
reactivity
with
certain
dienophiles,
without
interfering
biochemical
processes,
makes
them
ideal
bioorthogonal
ligation.
Despite
their
broad
utility,
current
synthetic
methods
are
costly
and
raise
safety
concerns,
particularly
during
scale‐up.
This
study
introduces
safer
more
cost‐effective
strategies
utilizing
zinc
chloride
or
boron
trifluoride
diethyl
etherate
catalysts.
These
alternatives
significantly
reduce
costs
enhance
safety,
potentially
expanding
the
applicability
tetrazine
synthesis
across
broader
research
domains.
Язык: Английский