Synthesis of polysubstituted spiroazepines via [4 + 3] annulation reaction of ninhydrin-derived Morita−Baylis−Hillman carbonates with 1‑heterodienes

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141478 - 141478

Опубликована: Янв. 1, 2025

Язык: Английский

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Structural Elucidation and Computational Studies of Novel Bidentate Organometallic Complexes of 2-Thiophene Carboxylic Acid with Ethyl-2-Amino Acetate for Antidiabetic Applications

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141829 - 141829

Опубликована: Фев. 1, 2025

Язык: Английский

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A glance into Schiff-based α-glucosidase inhibitors in medicinal chemistry

Medicinal Chemistry Research, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Язык: Английский

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A novel avenue in the successful synthesis of Schiff base macromolecules via innovative plasma and classical approaches

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 29, 2025

Schiff base macromolecules have been successfully synthesized, utilizing a classical chemistry route and dielectric barrier discharge (DBD) plasma technique. The synthesis of monomeric units has accomplished through typical reactions aldehyde amine functional molecules. condensation polymerization the molecules instigated chemically, using p-toluene sulfonyl chloride in refluxed ethanol. molecular weight obtained polymers was discovered to be 524, 664 1,503,228 for 4a 4b, respectively. Additionally, were prompted, employing Dielectric Barrier Discharge atmospheric pressure air DBD demonstrated very powerful routine produce high weights with optimum condition at 5 min. duration time, which could an ecofriendly strategy acquire this class materials. new polymeric materials characterized FTIR NMR spectroscopy. Moreover, complexation polymer 4b various metal moieties, Ru (II), Co Cu Ni executed order comparative study their antitumor activity against MCF-7, HCT-116, HepG-2 cell lines. Furthermore, density theory exploited optimize complexes, HOMO-LUMO energy gap calculated, utilized examine inter/intra charge transfer. electrostatic potential map similarly quantified investigate reactive sites that are present investigated result docking confirmed these complexed adopted numerous important interactions amino acid targeted enzyme.

Язык: Английский

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Studies on inhibition of α-glucosidase using debittered formulation of Bacopa monnieri juice: Enzyme inhibition kinetics, interaction strategy, and molecular docking approach

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 285, С. 138250 - 138250

Опубликована: Дек. 3, 2024

Язык: Английский

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