Benzimidazole(s): synthons, bioactive lead structures, total synthesis, and the profiling of major bioactive categories

RSC Advances, Год журнала: 2025, Номер 15(10), С. 7571 - 7608

Опубликована: Янв. 1, 2025

Benzimidazole, a fused bicyclic compound with benzene and pentacyclic 1,3-diazole moeities, has simple aromatic heterocyclic structure. The moiety become an indispensable anchor for the development of new pharmacologically active products, yielded several therapeutic agents anticancer, antihypertensive, antimicrobial, antifungal antiulcer effects. Benzimidazoles, as synthetically feasible pharmacophoric synthons, have been relentlessly pursued preparation analogues derivatives, they successfully developed into some most sought-after vital pharmacophores drug discovery. use varied substituents differing patterns around benzimidazole nucleus provided wide spectrum biological activities. In addition, constitutes building block production drugs, candidates, chemical entities, lead molecules. importance this bioactivity, e.g., antibacterial, antitubercular, antidiabetic, antifungal, anti-inflammatory, analgesic, antioxidant, antihistaminic, antimalarial activity, led us to take note provide overview synthetic approaches various derivatives together their actions. This review is projected further assist in design benzimidazole-based compounds optimized products towards drug-development strategies.

Язык: Английский

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Investigating the biological activities of N-(halophenyl)-1-(naphthalen-2-yl)methanimine compounds: synthesis, crystal structures, DFT computational, In vitro antidiabetes, and antioxidant studies

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142216 - 142216

Опубликована: Март 1, 2025

Язык: Английский

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Studies on inhibition of α-glucosidase using debittered formulation of Bacopa monnieri juice: Enzyme inhibition kinetics, interaction strategy, and molecular docking approach

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 285, С. 138250 - 138250

Опубликована: Дек. 3, 2024

Язык: Английский

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Synthesis, characterization, electronic properties, and cytotoxic activities on cancer cells line of novel Cu(II) complexes with benzimidazole-Schiff base tridentate ligand

Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 141239 - 141239

Опубликована: Дек. 1, 2024

Язык: Английский

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